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公开(公告)号：KR1020100110129A
公开(公告)日：2010-10-12
申请号：KR1020090028544
申请日：2009-04-02
Applicant: 대한민국(농촌진흥청장)
CPC classification number: A61L26/0057 , A61F2013/00157 , A61F2013/00391 , A61F2013/00919 , A61K8/987 , A61K9/0014 , A61K9/06 , A61K9/7023 , A61K35/63 , A61K47/44 , A61L15/40 , A61Q17/04 , A61Q19/08 , Y02A50/473
Abstract: PURPOSE: A composition for healing wound or treating burn is provided to promote skin cell regeneration and to ensure antibacterial effect. CONSTITUTION: A composition for healing wound or treating burn contains 0.001-10%(w/v) of bee venom as an active ingredient. The composition additionally contains bio-absorbable particle or fiber such as a gel matrix to help lesion application and bee venom absorption. The gel matrix is alginate or hyaluronic acid. The composition is formulated in dressing agent, ointment, or patch. An external use skin formulation contains bee venom as an active ingredient. A cosmetic product for anti-wrinkle or UV protection contains bee venom as an active ingredient.
Abstract translation: 目的：提供用于治疗伤口或治疗烧伤的组合物，以促进皮肤细胞再生并确保抗菌效果。 构成：用于治疗伤口或治疗烧伤的组合物含有0.001-10％（w / v）的蜂毒作为活性成分。 该组合物还含有生物可吸收颗粒或纤维如凝胶基质，以帮助病变应用和蜂毒吸收。 凝胶基质是藻酸盐或透明质酸。 该组合物配制在敷料剂，软膏剂或贴剂中。 外用皮肤制剂含有蜂毒作为活性成分。 抗皱或紫外线防护用化妆品含有蜂毒作为活性成分。
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公开(公告)号：KR1020100088389A
公开(公告)日：2010-08-09
申请号：KR1020090007580
申请日：2009-01-30
Applicant: 대한민국(농촌진흥청장) , 주식회사 청진바이오텍
Abstract: PURPOSE: A natural antibiotics containing bee venom and herb extract is provided to ensure high disinfection effect and to treat disease of piglet. CONSTITUTION: A natural antibiotics contains bee venom and herb extract as an active ingredient. The herb extract is obtained from Houttuynia cordata, Artemisia capillaris Thunb, green tea leaves. The natural antibiotics contains 0.01-5 weight% of bee venom, 5-20 weight% of herb extract, and 75-95 weight% of solvent.
Abstract translation: 目的：提供含有蜂毒和草药提取物的天然抗生素，以确保高消毒效果和治疗小猪疾病。 构成：天然抗生素含有蜂毒和草药提取物作为活性成分。 草药提取物由鱼腥草，青蒿，绿茶叶获得。 天然抗生素含有0.01-5重量％的蜂毒，5-20重量％的草药提取物和75-95重量％的溶剂。
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公开(公告)号：KR1020090036758A
公开(公告)日：2009-04-15
申请号：KR1020070101980
申请日：2007-10-10
Applicant: 대한민국(농촌진흥청장) , 동성제약주식회사
CPC classification number: A61K35/63 , A61K38/012
Abstract: A composition for preventing and treating osteoporosis comprising silk peptide as an active ingredient is provided to suppress the differentiation of osteoclast by using natural protein. A composition for preventing and treating osteoporosis comprises silk peptide as an active ingredient. The silk peptide is an acid of silk or hydrolysate of enzyme. The silk peptide is the pyrolysate of cocoon containing sericin. An amino acid composition of the silk peptide are 80 weight% or greater based on the total content of glycine 40-45 weight%, alanine 20-30 weight% and serine 10-20 weight%.
Abstract translation: 提供一种用于预防和治疗包含丝肽作为活性成分的骨质疏松症的组合物，以通过使用天然蛋白质来抑制破骨细胞的分化。 用于预防和治疗骨质疏松症的组合物包括丝肽作为活性成分。 丝肽是丝的酸或酶的水解产物。 丝肽是含有丝胶蛋白的茧的热解物。 基于甘氨酸40-45重量％，丙氨酸20-30重量％和丝氨酸10-20重量％的总含量，丝肽的氨基酸组成为80重量％以上。
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公开(公告)号：KR100579899B1
公开(公告)日：2007-10-19
申请号：KR1020050091937
申请日：2005-09-30
Applicant: 대한민국(농촌진흥청장) , 김철구
Abstract: 본 발명은 커버부재(1); 상기 커버부재가 부착되며, 일측에 소정간격으로 전선 안내홈(5')이 형성된 프레임(5); 소정 간격으로 전선 안내홈(2')이 형성되고 상기 전선의 장력을 조절하기 위해 상기 프레임(5)의 타측에서 이동이 가능하도록 상기 프레임(5)과 결합되는 조절판(2); 각 일단부가 음극과 양극에 각가 연결되며, 상기 프레임의 일측에 형성된 안내홈(5')과 상기 조절판(2)에 형성된 안내홈(2')에 지지되어 상기 프레임(5)의 내부공간부(4)에 일정간격으로 배열되는 한쌍의 전선(3); 상기 프레임(5)의 홈에 결합하며, 봉독이 수집되는 유리판(7); 상기 유리판(7)의 배면에 부착되어 유리판을 보호하는 바닥판(8); 상기 유리판(7) 및 바닥판(8)을 프레임의 내부공간부(4)에 고정시키는 고정부재(9); 상기 프레임(5)에 지지된 한쌍의 전선(3)과 전기적으로 접속되며 전기신호의 온/오프 및 소정 레벨로 출력전압을 승압시켜 시간별로 제어하는 컨트롤러(11); 및 상기 컨트롤러(11)에 전원을 공급하는 전원공급부(15)를 포함하는 봉독채집장치를 제공한다.
봉독 채집 장치-
公开(公告)号：KR100758814B1
公开(公告)日：2007-09-19
申请号：KR1020060108852
申请日：2006-11-06
Applicant: 대한민국(농촌진흥청장)
Abstract: A simple purifying method of bee venom is provided to minimize the change of bee venom ingredients in case that the bee venom is stored for long time and enable the continuous supply of bee venom. Therefore, the purified bee venom can be used for the development of food and medical supplies including bee venom as the ingredients. A method for purifying the bee venom collected from a glass collection board of a bee venom collecting apparatus comprises the steps of: a first process for dissolving the collected bee venom in a thirdly sterilized distilled water for 5~15min, wherein the weight ratio of the bee venom and the distilled water is 1:45~55; a second process for centrifuging 300g of the solution obtained from the first process at 4°C for 5~15min; a third process for filtering out supernatant from the centrifuged solution by filter paper having a pore size of 8mum, or by a vacuum pump; and a fourth process for drying the filtrate frozen at -65~75°C.
Abstract translation: 提供了一种简单的蜂毒净化方法，以便在蜂毒液长时间储存并能够连续供应蜂毒的情况下，最大限度地减少蜂毒成分的变化。 因此，纯化的蜂毒可用于开发包括蜂毒作为成分的食品和医疗用品。 一种从蜂毒收集装置的玻璃收集板收集的蜂毒的净化方法，包括以下步骤：将收集的蜂毒溶解在第三灭菌蒸馏水中5〜15min的第一工序，其中， 蜂毒和蒸馏水为1：45〜55; 将第一次处理得到的300g溶液在4℃离心5〜15min的第二种方法; 通过孔径为8μm的滤纸或通过真空泵从离心的溶液中滤出上清液的第三种方法; 以及在-65〜75℃下干燥冷冻的滤液的第四种方法。
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Patent Agency Ranking
公开(公告)号：KR1020050040124A
公开(公告)日：2005-05-03
申请号：KR1020050027320
申请日：2005-03-31
Applicant: 주식회사 바이오그랜드 , 대한민국(농촌진흥청장)
IPC: A23L1/305
Abstract: 본 발명은 뇌신경질환의 예방 또는 치료용 조성물에 관한 것으로서, 보다 상세하게는 (a) 실크 단백질의 분해에 의해 생성된 실크 펩타이드의 약제학적 유효량; 및 (b) 약제학적 담체를 포함하는 뇌신경질환의 예방 또는 치료용 조성물에 관한 것이다.
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公开(公告)号：KR1020040073153A
公开(公告)日：2004-08-19
申请号：KR1020030009138
申请日：2003-02-13
Applicant: 주식회사 바이오그랜드 , 대한민국(농촌진흥청장)
IPC: A61K38/00
CPC classification number: A61K38/02 , A23L33/18 , A23V2002/00 , A23V2200/322 , A61K9/08 , A61K9/14
Abstract: PURPOSE: Compositions for preventing or treating brain neuronal diseases and improving recognition function are provided, thereby effectively preventing or treating brain neuronal diseases with less of side-effects. CONSTITUTION: The composition for preventing or treating brain neuronal diseases comprises (a) a pharmaceutically effective amount of silk peptide produced by decomposition of silk protein; and (b) pharmaceutically acceptable carriers, wherein the silk protein is silk sericin or silk fibroin; the decomposition of silk protein is carried out by using calcium solution such as calcium chloride, acid hydrolysis, protein decomposing enzyme such as thermoase, flavourzyme, sumizyme, protamex and protin and a combination thereof; and the average molecular weight of the silk peptide is 300 to 100,000 dalton. The composition for improving recognition function comprises (a) a pharmaceutically effective amount of silk peptide produced by decomposition of silk protein; and (b) pharmaceutically acceptable carriers.
Abstract translation: 目的：提供预防或治疗脑神经元疾病和改善识别功能的组合物，从而有效预防或治疗脑神经元疾病，副作用较少。 构成：用于预防或治疗脑神经元疾病的组合物包括（a）通过丝蛋白分解产生的药学有效量的丝肽; 和（b）药学上可接受的载体，其中丝蛋白是丝丝素或丝素蛋白; 丝蛋白的分解是通过使用氯化钙，酸水解，蛋白质分解酶如热解酶，香料酶，硫酸钠，protamex和protin等钙溶液及其组合进行的; 丝肽的平均分子量为300〜100,000道尔顿。 用于改善识别功能的组合物包括（a）通过丝蛋白分解产生的药学有效量的丝肽; 和（b）药学上可接受的载体。
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公开(公告)号：KR1020030001659A
公开(公告)日：2003-01-08
申请号：KR1020010036463
申请日：2001-06-26
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: An extract of Protaetia brevitarsis which has almost the same liver protecting effect as silymarin as a conventional liver disease treating agent is provided which can be effectively used as an effective ingredient for a liver disease treating agent or health supplementary agent. CONSTITUTION: Distilled water is added to larvae powder of Protaetia brevitarsis and extracted and the extract is passed through a dialysis membrane to produce a Protaetia brevitarsis extract having a molecular weight of 1,000 or less. The extract is formulated to be administered in a dose of 1 to 2,500mg/kg/day, preferably 10 to 500mg/kg/day and can recover the liver effectively when hepatotoxicity is induced by drugs such as carbon dioxide.
Abstract translation: 目的：提供与常规肝脏疾病治疗剂几乎与水飞蓟素相同的肝保护作用的红曲霉提取物，其可以有效地用作肝脏疾病治疗剂或健康补充剂的有效成分。 构成：将蒸馏水加入到短白茅的幼虫粉末中，萃取，将提取物通过透析膜，制成分子量为1000以下的短叶提取物。 将提取物配制成以1-2500mg / kg /天，优选10-500mg / kg /天的剂量施用，并且当药物如二氧化碳诱导肝毒性时，可以有效地回收肝脏。
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公开(公告)号：KR100315168B1
公开(公告)日：2001-11-30
申请号：KR1019990002672
申请日：1999-01-28
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은신규한창상피복재및 그의제조방법에관한것으로, 더욱구체적으로는실크단백질을구성하는펩타이드중 피브로인단백질용액을급속동결건조하여스폰지막의형태로제조하는것에의해생체적합성, 막의일부가녹아들어가창상면과밀착하는특성, 수분투과력, 피부재생능력등이우수한창상피복재를제공하는것에관한것이다.
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公开(公告)号：KR101704123B1
公开(公告)日：2017-02-20
申请号：KR1020140136554
申请日：2014-10-10
Applicant: 대한민국(농촌진흥청장) , 주식회사 청진바이오텍
Abstract: 본발명은 i) 정제봉독을멸균증류수에용해시키는단계; ii) 상기용해된정제봉독을원심분리하여 3kDa 이상의단백질을분리하는단계; iii) 상기원심분리후 분리된정제봉독하층액을동결건조하는단계; iv) 액체크로마토그래피를이용하여상기동결건조된봉독에서멜리틴, 아파민, 포스포리파아제 A2 및 MCD 펩타이드를분리정제하고남은분획물을획득하는단계; 및 v) 상기남은분획물을동결건조하는단계;를포함하는단백질및 펩타이드가제거된것을특징으로하는봉독의분리방법에관한것이다. 또한본 발명은상기방법으로분리된단백질및 펩타이드가제거된봉독및 이를포함하는식품조성물에관한것이다.
Abstract translation: 本发明涉及不含蛋白质和肽的蜂毒提取方法，包括以下步骤：i）将精制蜂毒液溶解于无菌蒸馏水中; ii）通过对溶解的蜂毒进行离心分离过程来提取至少3kDa的蛋白质; iii）进行离心分离处理后的冻干蜂毒丸; iv）使用液相色谱法从冷冻干燥的蜂毒中提取和提炼蜂毒素，阿帕胺，磷脂酶A2和MCD肽，并获得剩余部分; 和v）冷冻干燥剩余部分。 此外，本发明涉及通过该方法除去蛋白质和肽的蜂毒素和包含蜂毒的食物组合物。
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