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公开(公告)号：KR100315168B1
公开(公告)日：2001-11-30
申请号：KR1019990002672
申请日：1999-01-28
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은신규한창상피복재및 그의제조방법에관한것으로, 더욱구체적으로는실크단백질을구성하는펩타이드중 피브로인단백질용액을급속동결건조하여스폰지막의형태로제조하는것에의해생체적합성, 막의일부가녹아들어가창상면과밀착하는특성, 수분투과력, 피부재생능력등이우수한창상피복재를제공하는것에관한것이다.
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公开(公告)号：KR1020000051938A
公开(公告)日：2000-08-16
申请号：KR1019990002672
申请日：1999-01-28
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: A wound skin-covering film consisting of fibroin protein and preparation method thereof are provided. CONSTITUTION: Fibroin is obtained from silkworms by using protease of Aspergillus oryzae. The fibroin film should have a alpha-helix structure to be attached closely on the wound. A fibrin solution for producing the fibrin film is prepared by the steps of: dissolving fibroin obtained from silkworms in hydrogen chloride, hydrogen sulfate, lithium chloride, lithium bromide, sodium iodine, zinc chloride, and calcium chloride; and removing salts by filtration with filter such as cellophane membrane. The fibroin film is prepared by freeze-drying the fibroin solution and the resulting film should have a 0.1 to 10 mm of thickness.
Abstract translation: 目的：提供一种由丝心蛋白组成的伤口皮肤覆盖膜及其制备方法。 构成：通过使用米曲霉的蛋白酶从蚕获得纤维蛋白。 丝心蛋白膜应具有紧密附着在伤口上的α-螺旋结构。 通过以下步骤制备用于制备纤维蛋白膜的纤维蛋白溶液：将从蚕获得的丝心蛋白溶解在氯化氢，硫酸氢盐，氯化锂，溴化锂，碘化钠，氯化锌和氯化钙中; 并用过滤器如玻璃纸膜过滤除去盐。 丝心蛋白膜通过冷冻干燥丝心蛋白溶液制备，所得膜应具有0.1至10mm的厚度。
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