Abstract:
PURPOSE: An anti-inflammation or anti-cancer composition containing Polytrichum commune extract or fraction is provided to suppress NF-kappaB activation and to suppress expression of PGE2 gene. CONSTITUTION: An anti-inflammation or anti-cancer composition contains Polytrichum commune extract or fraction. A method for producing the Polytrichum commune extract comprises: a step of washing Polytrichum commune with distilled water at 100°C for 5 minutes to inactivate an enzyme; a step of pulverizing at 5,000rpm for 5minutes, 6,000rpm for 5 minutes, 7,000rpm for 20 minutes; and a step of centrifuging at 5,000xg for 30 minutes, and a step of drying supernatant. The Polytrichum commune fraction is a chloroform or butanol fraction.
Abstract:
PURPOSE: A pharmaceutical composition containing melitin ingredients is provided to treat liver diseases. CONSTITUTION: A pharmaceutical composition for treating liver diseases contains 0.001-0.05 wt% of melittin as an active ingredient. Mellitin is isolated from honey bee-derived bee venom. The composition additionally contains pharmaceutically acceptable carrier. Mellitin reduces inflammation-inducing cytokine expression in a liver tissue. The inflammation-inducing cytokine is TNF-alpha, IL-1beta, IL-6, or VCAM. [Reference numerals] (AA) Tumor necrosis factor(TNF-α); (BB) NC control group; (CC) TAA experimental group of liver cirrhosis; (DD) TAA + Mel experimental group of liver cirrhosis + melittin administration