公开(公告)号：KR100956576B1

公开(公告)日：2010-05-07

申请号：KR1020070063911

申请日：2007-06-27

Applicant: 아주대학교산학협력단

Inventor： 김철호

IPC: A61K31/353 ,  A61P35/00

Abstract: 본 발명은 에피카테킨(epicatechin)을 유효성분으로 하는 항암제 및 방사선 치료시 유발되는 청각유모세포의 세포사멸기전을 억제하는 조성물에 관한 것이다.
에피카테킨(epicatechin), 항암제, 방사선 치료, 청각 보호

公开(公告)号：KR102015883B1

公开(公告)日：2019-09-03

申请号：KR1020180030995

申请日：2018-03-16

Applicant: 주식회사 플라리트 ,  아주대학교산학협력단 ,  (주)아이씨디

Inventor： 김철호 ,  이승호

IPC: A61N1/44 ,  A61H35/00 ,  A61H33/02 ,  A61H33/00

公开(公告)号：KR101933920B1

公开(公告)日：2018-12-31

申请号：KR1020170102295

申请日：2017-08-11

Applicant: 아주대학교산학협력단

Inventor： 김철호 ,  강성운

IPC: A61N1/44 ,  H05H1/24 ,  A61K9/00

公开(公告)号：KR1020130041896A

公开(公告)日：2013-04-25

申请号：KR1020137000866

申请日：2011-06-13

Applicant: 아주대학교산학협력단 ,  한국화학연구원

Inventor： 김철호 ,  정영식

IPC: C07D215/22 ,  C07D215/18 ,  A61K31/4709 ,  A61P27/16

CPC classification number: C07D215/38 ,  A23L33/10 ,  C07C231/02 ,  C07C233/55

Abstract: PURPOSE: A novel compound for hearing protection is provided to suppress an apoptotic mechanism of auditory hair cells and to protect an auditory system and hearing. CONSTITUTION: A novel compound for hearing protection is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of reacting a compound of chemical formula 2 with 2-(4-fluorophenyl)acetyl chloride to prepare a compound of chemical formula 3; a step of reacting NaH with the compound of chemical formula 3 to prepare a compound of chemical formula 4; a step of reacting the compound of chemical formula 4 with SO_2Cl_2 to prepare a compound of chemical formula 5; a step of reacting NaH with the compound of chemical formula 5 to prepare a compound of chemical formula 6; and a step of reacting H_2 with the compound of chemical 6.

Abstract translation: 目的：提供一种用于听力保护的新型化合物，以抑制听觉毛细胞的凋亡机制，并保护听觉系统和听觉。 化学式1化合物的制备方法包括：使化学式2的化合物与2-（4-氟苯基）乙酰氯反应，制备化合物 化学式3化合物; 将NaH与化学式3的化合物反应以制备化学式4的化合物的步骤; 使化学式4的化合物与SO 2 Cl 2反应以制备化学式5的化合物的步骤; 将NaH与化学式5的化合物反应以制备化学式6的化合物的步骤; 和H_2与化合物6反应的步骤。