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    대추 추출물 및 감귤류 과피 추출물을 포함하는 지질대사개선 및 혈압강하용 조성물
    38.
    发明公开
    대추 추출물 및 감귤류 과피 추출물을 포함하는 지질대사개선 및 혈압강하용 조성물 失效
    含有JUJUBE萃取物的组合物和提取脂质代谢和降低血液压力的ORGANGES RIND提取物

    公开(公告)号：KR1020010015512A

    公开(公告)日：2001-02-26

    申请号：KR1020000063394

    申请日：2000-10-27

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  손광희 ,  정태숙 ,  배기환 ,  박용복 ,  최명숙 ,  권용국 ,  현병화 ,  최양규 ,  이철호 ,  문석식

    IPC: A61K36/725 ,  A61K36/752 ,  A61P3/06 ,  A61P9/12

    Abstract: PURPOSE: A composition containing the extract of jujube and the extract of citrus rind is provided for improving lipid metabolism and lowering blood pressure, so that it can prevent liver diseases, hypertension, arteriosclerosis, hyperlipemia and cancer. CONSTITUTION: The composition contains 0.1 to 5g/weight kg/day of the extract of jujube and 0.1 to 10g/weight kg/day of the extract of citrus rind in a weight ratio of 1:1 to 100:1, in which the extract of jujube is produced by adding 2 to 5 liter of 70 to 95% ethanol into 1 kg of jujube, and extracting them at 50 to 60deg.C for 1 to 24 hours, or by adding 2 to 5 liter of water into 1 kg of citrus rind, and extracting them at 70 to 121deg.C for 30 minutes to 12 hours; the extract of citrus rind is produced by drying citrus rind, adding 3 to 30 liter of 20 to 95% ethanol into 1kg of dried rind, extracting them at 25 to 80deg.C for 1 to 12 hours, filtering the extract, and condensing it under reduced pressure, wherein citrus includes orange, lemon, tangerine, grapefruit or citron.

    Abstract translation: 目的：提供含有枣提取物和柑橘皮提取物的组合物，用于改善脂质代谢和降低血压，从而可以预防肝脏疾病，高血压，动脉硬化，高脂血症和癌症。 构成：组合物以1：1〜100：1的重量比含有0.1〜5g / kg的枣提取物和0.1〜10g / kg的柑橘皮提取物，其中提取物 通过向1kg的枣中加入2〜5升的70〜95％的乙醇，在50〜60℃下提取1〜24小时，或者将2〜5升的水加入1kg的 柑橘皮，70〜121℃，30分钟〜12小时提取; 柑橘皮提取物是通过干燥柑橘皮制成的，将3〜30升20〜95％乙醇加入1kg干燥的皮中，在25〜80℃下提取1〜12小时，过滤提取物，冷凝 在减压下，其中柑橘包括橙，柠檬，橘子，葡萄柚或柚子。

    바이오플라보노이드 화합물을 포함하는 혈당 강하용 조성물
    39.
    发明公开
    바이오플라보노이드 화합물을 포함하는 혈당 강하용 조성물 无效
    含有生物素化合物的高分子组合物

    公开(公告)号：KR1020010015494A

    公开(公告)日：2001-02-26

    申请号：KR1020000058704

    申请日：2000-10-06

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  배기환 ,  박용복 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  현병화 ,  최양규 ,  이철호 ,  안병태 ,  이새봄

    IPC: A23L1/29

    Abstract: PURPOSE: A hypotensive composition containing a bioflavonoid compound is provided to use itself as a therapeutic agent for glycosemia or as a health food. CONSTITUTION: A hypotensive composition comprises an effective amount, preferably, 0.01-50 wt.% of bioflavonoid of formula (1) and a pharmaceutical acceptable carrier thereof. The flavonoids consist in citrus fruits such as orange, lemon, citron, grapefruit and the like. The composition containing the flavonoid compounds is useful to treat glycosemia. To drop the blood sugar level, the flavonoid compound of formula (1) can be added to foods, for example meats, beverages, snacks, chocolates etc. In the formula (1), R1 is OH, rutinosyl or rhaminosyl group; R2 is H, OH or rutinosyl group; R3 is H or OH group; R4 is OH or methoxy group; X is single bond or double bond.

    Abstract translation: 目的：提供含有生物类黄酮化合物的低血压组合物作为糖血症的治疗剂或作为保健食品。 构成：低血压组合物包含有效量，优选0.01-50重量％的式（1）的生物类黄酮及其药学上可接受的载体。 黄酮类化合物包括橙子，柠檬，柚子，葡萄柚等柑橘类水果。 含有类黄酮化合物的组合物可用于治疗糖血症。 为了降低血糖水平，式（1）的类黄酮化合物可以加入到食品中，例如肉类，饮料，小吃，巧克力等。在式（1）中，R 1是OH，芸香酰基或脱氨基糖基; R2是H，OH或芸香糖基; R3是H或OH基; R4是OH或甲氧基; X是单键或双键。

    디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물
    40.
    发明公开
    디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물 失效
    含有二氢DI UL UL UL UL UL A A A A A A A A A A A A A A A A A A A A A A A A

    公开(公告)号：KR1020010007625A

    公开(公告)日：2001-01-26

    申请号：KR1020000058789

    申请日：2000-10-06

    Applicant: 한국과학기술연구원

    Inventor： 복성해 ,  정태숙 ,  배기환 ,  박용복 ,  최명숙 ,  문석식 ,  권용국 ,  이은숙 ,  현병화 ,  최양규 ,  이철호 ,  안병태 ,  이새봄

    IPC: A61K31/70

    Abstract: PURPOSE: A composition containing diosmin is provided for preventing and treating ateriosclerosis and hyperlipemia, thereby adhesion of macrophage-lipid complex on inner layer of artery is strongly inhibited, the amounts of cholesterol and fat in serum is decreased, and the activity of ACAT and HMG-CoA reductase is inhibited. CONSTITUTION: The amount of cholesterol in serum can be decreased by inhibiting the activities of acyl CoA:cholesterol-o-acyltransferase(ACAT) in liver, cholesterol ester transfer protein(CETP) transferring cholesterol between lipid proteins, 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) relating to biosynthesis of cholesterol in liver. Diosmin(C28H32O15, M.W. 608.55) may be obtained from vegetables and oranges or be synthesized. The composition containing an effective amount of diosmin, that is, 0.1 to 500 mg/kg, preferably 1 to 100 mg/kg a day, is orally or topically administrated into a patient and the dose thereof may be variable by patient's age, weight, sex, health, diet, severity of disease, and so on. The composition containing diosmin may be added into foods and drinks in an amount of 0.01 to 10 wt.%, preferably 0.1 to 5 wt.% of diosmin.

    Abstract translation: 目的：提供含有diosmin的组合物，用于预防和治疗动脉硬化和高脂血症，从而强烈抑制巨噬细胞 - 脂质复合物对动脉内层的粘附，血清中胆固醇和脂肪的含量降低，ACAT和HMG的活性 -CoA还原酶被抑制。 构成：通过抑制肝脏中酰基CoA：胆固醇 - 邻 - 酰基转移酶（ACAT），胆固醇酯转移蛋白（CETP）在脂质蛋白，3-羟基-3-甲基戊二醛之间转运胆固醇的活性，可以降低血清中的胆固醇含量 辅酶A（HMG-CoA）涉及胆固醇在肝脏中的生物合成。 Diosmin（C28H32O15，M.W. 608.55）可以从蔬菜和橙子中获得或被合成。 将包含有效量的二糖苷的组合物，即每天0.1至500mg / kg，优选1至100mg / kg，口服或局部施用于患者，其剂量可以根据患者的年龄，体重， 性别，健康，饮食，疾病严重程度等。 含有diosmin的组合物可以以diosmin的0.01〜10重量％，优选0.1〜5重量％的量添加到食品和饮料中。

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