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公开(公告)号：KR100291141B1
公开(公告)日：2001-07-12
申请号：KR1019980037962
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: 본 발명은 디오스민(diosmin)을 포함하는 동맥경화증 및 고지혈증의 예방 및 치료용 조성물에 관한 것으로, 디오스민은 동물에게 투여되었을 때 동맥내피에 대식세포-지질 복합체가 침착되는 것을 강력히 억제할 뿐만 아니라, ACAT 및 HMG-CoA 환원효소의 활성을 억제하고, 혈중 콜레스테롤 및 중성지질의 농도를 감소시키므로, 동맥경화증 및 고지혈증의 예방 및 치료제로서 유용하게 사용될 수 있다.
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公开(公告)号：KR1020010015494A
公开(公告)日：2001-02-26
申请号：KR1020000058704
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A23L1/29
Abstract: PURPOSE: A hypotensive composition containing a bioflavonoid compound is provided to use itself as a therapeutic agent for glycosemia or as a health food. CONSTITUTION: A hypotensive composition comprises an effective amount, preferably, 0.01-50 wt.% of bioflavonoid of formula (1) and a pharmaceutical acceptable carrier thereof. The flavonoids consist in citrus fruits such as orange, lemon, citron, grapefruit and the like. The composition containing the flavonoid compounds is useful to treat glycosemia. To drop the blood sugar level, the flavonoid compound of formula (1) can be added to foods, for example meats, beverages, snacks, chocolates etc. In the formula (1), R1 is OH, rutinosyl or rhaminosyl group; R2 is H, OH or rutinosyl group; R3 is H or OH group; R4 is OH or methoxy group; X is single bond or double bond.
Abstract translation: 目的：提供含有生物类黄酮化合物的低血压组合物作为糖血症的治疗剂或作为保健食品。 构成：低血压组合物包含有效量，优选0.01-50重量％的式（1）的生物类黄酮及其药学上可接受的载体。 黄酮类化合物包括橙子，柠檬，柚子，葡萄柚等柑橘类水果。 含有类黄酮化合物的组合物可用于治疗糖血症。 为了降低血糖水平，式（1）的类黄酮化合物可以加入到食品中，例如肉类，饮料，小吃，巧克力等。在式（1）中，R 1是OH，芸香酰基或脱氨基糖基; R2是H，OH或芸香糖基; R3是H或OH基; R4是OH或甲氧基; X是单键或双键。
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3.发明公开디오스민을 포함하는 동맥경화증 및 고지혈증의 예방 및치료용 조성물 失效含有二氢DI UL UL UL UL UL A A A A A A A A A A A A A A A A A A A A A A A A
公开(公告)号：KR1020010007625A
公开(公告)日：2001-01-26
申请号：KR1020000058789
申请日：2000-10-06
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: PURPOSE: A composition containing diosmin is provided for preventing and treating ateriosclerosis and hyperlipemia, thereby adhesion of macrophage-lipid complex on inner layer of artery is strongly inhibited, the amounts of cholesterol and fat in serum is decreased, and the activity of ACAT and HMG-CoA reductase is inhibited. CONSTITUTION: The amount of cholesterol in serum can be decreased by inhibiting the activities of acyl CoA:cholesterol-o-acyltransferase(ACAT) in liver, cholesterol ester transfer protein(CETP) transferring cholesterol between lipid proteins, 3-hydroxy-3-methylglutaryl coenzyme A(HMG-CoA) relating to biosynthesis of cholesterol in liver. Diosmin(C28H32O15, M.W. 608.55) may be obtained from vegetables and oranges or be synthesized. The composition containing an effective amount of diosmin, that is, 0.1 to 500 mg/kg, preferably 1 to 100 mg/kg a day, is orally or topically administrated into a patient and the dose thereof may be variable by patient's age, weight, sex, health, diet, severity of disease, and so on. The composition containing diosmin may be added into foods and drinks in an amount of 0.01 to 10 wt.%, preferably 0.1 to 5 wt.% of diosmin.
Abstract translation: 目的：提供含有diosmin的组合物，用于预防和治疗动脉硬化和高脂血症，从而强烈抑制巨噬细胞 - 脂质复合物对动脉内层的粘附，血清中胆固醇和脂肪的含量降低，ACAT和HMG的活性 -CoA还原酶被抑制。 构成：通过抑制肝脏中酰基CoA：胆固醇 - 邻 - 酰基转移酶（ACAT），胆固醇酯转移蛋白（CETP）在脂质蛋白，3-羟基-3-甲基戊二醛之间转运胆固醇的活性，可以降低血清中的胆固醇含量 辅酶A（HMG-CoA）涉及胆固醇在肝脏中的生物合成。 Diosmin（C28H32O15，M.W. 608.55）可以从蔬菜和橙子中获得或被合成。 将包含有效量的二糖苷的组合物，即每天0.1至500mg / kg，优选1至100mg / kg，口服或局部施用于患者，其剂量可以根据患者的年龄，体重， 性别，健康，饮食，疾病严重程度等。 含有diosmin的组合物可以以diosmin的0.01〜10重量％，优选0.1〜5重量％的量添加到食品和饮料中。
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公开(公告)号：KR1020000026393A
公开(公告)日：2000-05-15
申请号：KR1019980043909
申请日：1998-10-20
Applicant: 한국과학기술연구원
IPC: A61K31/35
CPC classification number: A61K31/352 , A61K31/7034 , A61K31/704
Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.
Abstract translation: 目的：提供一种用于增加血清高密度脂蛋白含有生物类黄酮的组合物，可用于预防和治疗心脏循环系统疾病。 构成：用于增加高密度脂蛋白的医药组合物包括（i）有效量的以下通式（I）的生物类黄酮或含有它们的植物提取物，其中每个R 1 -R 9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的苯基） ），具有5-9个碳原子的环烷氧基，其被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代，具有5-9个碳原子的环烷基羰基氧基，被一至三个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被一个 至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。
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公开(公告)号：KR100363180B1
公开(公告)日：2003-01-24
申请号：KR1019980043909
申请日：1998-10-20
Applicant: 한국과학기술연구원
IPC: A61K31/35
Abstract: PURPOSE: A composition for increasing serum high density lipoprotein containing bioflavonoids is provided which is useful for preventing and treating diseases of cardiac circulatory organs. CONSTITUTION: The medical composition for increasing high density lipoprotein consists of(i) an effective amount of bioflavonoids of the following general formula(I) or a plant extract containing thereof, where each R¬1-R¬9 is independently hydrogen, hydroxy, alkoxy having 1-9 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), cycloalkyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, cycloalkylcarbonyloxy having 5-9 carbon atoms which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido, acyloxy having 2-10 or 16-18 carbon atoms(optionally, which is able to include hydroxy, alkoxy having 1-5 carbon atoms, aryloxy or phenyl group which is substituted by one to three substituents selected from hydroxy, alkoxy, aryloxy, halogen, nitro and amido), or rutinosyl, and X is either a single bond or a double bond; and (ii) a medically acceptable carrier.
Abstract translation: 目的：提供一种用于增加含血清高密度脂蛋白的生物类黄酮的组合物，其用于预防和治疗心脏循环器官疾病。 组成：用于增加高密度脂蛋白的药物组合物由（i）有效量的下列通式（I）的生物类黄酮或含有其的植物提取物组成，其中每个R 1 -R 1不是9独立地是氢，羟基， 具有1-9个碳原子的烷氧基（任选地，其能够包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被1-3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基 ），被一至三个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的具有5-9个碳原子的环烷氧基，具有5-9个碳原子的环烷氧基，其被1-3个选自羟基， 烷氧基，芳氧基，卤素，硝基和酰氨基，具有2-10或16-18个碳原子的酰氧基（任选地，其可以包括羟基，具有1-5个碳原子的烷氧基，芳氧基或被取代的苯基 y选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的1至3个取代基）或芸香糖基，X为单键或双键; 和（ii）医学上可接受的载体。
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Patent Agency Ranking
公开(公告)号：KR100291142B1
公开(公告)日：2001-07-12
申请号：KR1019980037963
申请日：1998-09-15
Applicant: 한국과학기술연구원
Abstract: 본 발명은 네오헤스페리딘 디하이드로칼콘(neohesperidin dihydrochalcone)을 포함하는 동맥경화증, 고지혈증, 간 질환, 고혈당증의 예방 및 치료용 조성물에 관한 것으로, 본 발명의 조성물은 의약용, 식품용 및 음료용 조성물을 포함한다.
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7.发明授权네오헤스페리딘 디하이드로칼콘을 포함하는 동맥경화증,고지혈증, 간 질환, 고혈당증의 예방 및 치료용 조성물 失效用于预防和治疗动脉硬化，高脂血症，肝病，高血糖的组合物，包括新霉素二氢查耳酮
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公开(公告)号：KR100291140B1
公开(公告)日：2001-05-15
申请号：KR1020000062334
申请日：2000-10-23
Applicant: 한국과학기술연구원
IPC: A61K31/366
Abstract: 본 발명은 탄닌(tannin), 또는 탄닌 유래 갈산(gallic acid) 또는 엘라그산(ellagic acid)을 포함하는 동맥경화증, 고지혈증 및 간 질환의 예방 및 치료용 조성물에 관한 것으로, 탄닌, 갈산 또는 엘라그산은 동물에게 투여되었을 때 동맥내피에 대식세포-지질 복합체가 침착되는 것을 강력히 억제할 뿐만 아니라, 동물의 혈청 GOT(glutamate-oxaloacetate transaminase), GPT(glutamate-pyruvate transaminase), γGTP(γ-glutamyl transpeptidase) 및 혈중 지질의 농도를 낮추고, 간세포의 손상 및 지방간화를 강력히 억제하므로, 본 발명의 조성물은 동맥경화증, 고지혈증 및 간 질환의 예방 및 치료제로서 유용하게 사용될 수 있다.
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公开(公告)号：KR1020010015490A
公开(公告)日：2001-02-26
申请号：KR1020000056166
申请日：2000-09-25
Applicant: 한국과학기술연구원
IPC: A23L1/29
Abstract: PURPOSE: A food or drink composition including a bioflavonoid of formula(I) or extract of vegetables or citrus fruits containing the bioflavonoid is provided. This composition prevents hypertension, arteriosclerosis and a stroke of paralysis by increasing the plasma high density lipoprotein level in the body. CONSTITUTION: The composition for increasing plasma high density lipoprotein(HDL) level comprises a bioflavonoid of formula(I), wherein i) R1 to R9 are each independently hydrogen; hydroxy group; C1-9 alkoxy group optionally substituted with one or more substituents selected from the group consisting of hydroxy, C1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; a C5-9 cycloalkyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; C5-9 cycloalkylcarbonyloxy group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen, nitro and amido group; C2-10 or C16-18 acyloxy group optionally substituted with one or more substituents selected from the group consisting of a hydroxy, C1-5 alkoxy, aryloxy, and phenyl group substituted with 1 to 3 substituents selected from the group consisting of a hydroxy, alkoxy, aryloxy, halogen and nitro group; rutinosyl group; or rhaminosyl group, and ii) X is a single or double bond. The bioflavonoid of formula(I) or extract of vegetables or citrus fruits containing the bioflavonoid can be added to various foods or drinks.
Abstract translation: 目的：提供包含式（I）的生物类黄酮或含有生物类黄酮的蔬菜或柑橘类水果提取物的食品或饮料组合物。 该组合物通过增加体内血浆高密度脂蛋白水平来预防高血压，动脉硬化和瘫痪中风。 构成：用于增加血浆高密度脂蛋白（HDL）水平的组合物包含式（I）的生物类黄酮，其中i）R 1至R 9各自独立地为氢; 羟基; 任选地被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自羟基，烷氧基，芳氧基，卤素取代基的取代基取代的取代基取代的C1-9烷氧基 ，硝基和酰氨基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C5-9环烷氧基; 被1至3个选自羟基，烷氧基，芳氧基，卤素，硝基和酰氨基的取代基取代的C 5-9环烷基羰基氧基; 任选被一个或多个选自羟基，C 1-5烷氧基，芳氧基和被1至3个选自下组取代的取代基的苯基取代的C 2-10或C16-18酰氧基：羟基， 烷氧基，芳氧基，卤素和硝基; 芸香酰基; 或rhaminosyl基，和ii）X是单键或双键。 式（I）的生物类黄酮或含有生物类黄酮的蔬菜或柑橘类水果的提取物可以添加到各种食品或饮料中。
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公开(公告)号：KR1020000019719A
公开(公告)日：2000-04-15
申请号：KR1019980037962
申请日：1998-09-15
Applicant: 한국과학기술연구원
IPC: A61K31/70
CPC classification number: A23L33/10 , A23C9/152 , A23V2002/00 , A23V2200/3262 , A61K31/7048
Abstract: PURPOSE: A pharmaceutical composition and a functional food comprising diosmin are provided, for treating and preventing hyper lipidemia and arteriosclerosis. CONSTITUTION: The pharmaceutical composition comprises diosmin in effective amount; and pharmaceutically acceptable carriers. The functional food comprises 0.01-10 wt%, preferably 0.1-5 wt% of diosmin. Diosmin inhibits HMG CoA (3-hydroxy-3-methylglutaryl coenzyme) being a reduction enzyme which relates to the biosynthesis of cholesterol and ACAT (acyl CoA; cholesterol-O-acyltransferase) which transforms cholesterol into cholesteryl ester, and reduces the concentration of cholesterol in blood and neutral lipids. Also diosmin strongly inhibits the macrophage-lipid complex from being deposited or adsorbed onto the intra trial surface.
Abstract translation: 目的：提供药物组合物和包含diosmin的功能性食品，用于治疗和预防高脂血症和动脉硬化。 构成：药物组合物含有有效量的diosmin; 和药学上可接受的载体。 功能性食品包含diosmin的0.01-10重量％，优选0.1-5重量％。 Diosmin抑制作为还原酶的HMG CoA（3-羟基-3-甲基戊二酰辅酶），其涉及将胆固醇转化为胆固醇酯的胆固醇和ACAT（酰基辅酶A;胆固醇-O-酰基转移酶）的生物合成，并降低胆固醇的浓度 在血液和中性脂质中。 此外，diosmin还强烈地抑制巨噬细胞 - 脂质复合物沉积或吸附到试验表面。
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