公开(公告)号：KR1020130047458A

公开(公告)日：2013-05-08

申请号：KR1020110112506

申请日：2011-10-31

Applicant: 한국과학기술연구원

Inventor： 김수남 ,  이우정 ,  함정엽 ,  정유정 ,  황예란 ,  전영식 ,  윤구

IPC: A61K36/8984 ,  A61K31/045 ,  A61K31/047 ,  A61P3/04

CPC classification number: A61K36/8984 ,  A61K31/047 ,  A61K31/09 ,  A61K2236/333 ,  Y10S514/866 ,  Y10S514/909

Abstract: PURPOSE: A composition containing Dendrobium moniliforme is provided to prevent, relieve, or treat PPAR activation regulation-related diseases including obesity, metabolic diseases, and cardiovascular diseases. CONSTITUTION: A composition for preventing or treating PPAR activation regulation-related diseases contains Dendrobium moniliforme as an active ingredient. A composition for health functional food for preventing or treating PPAR activation regulation-related diseases contains Dendrobium moniliforme as an active ingredient. Dendrobium moniliforme is used as pulverized Dendrobium moniliforme, a dried material thereof, or a crude extract prepared by using a solvent which is selected from water, C1-C4 alcohol, and a combination thereof. The C1-C4 alcohol is methanol or ethanol. Dendrobium moniliforme is also used as a fraction which is prepared from the crude extract using n-hexane, methylene chloride, or ethyl acetate. [Reference numerals] (AA) Relative value(%); (BB) No treatment group, Troglitazone; (CC) Example ; (DD) Example ; (EE) Example n-Hx; (FF) Example MC; (GG) Example EA; (HH) Example fr2; (II) Example fr3; (JJ) Example fr2-2; (KK) Example fr2-5; (LL) Example compound 1; (MM) Example compound 2; (NN) Example compound 3; (OO) Example compound 4

Abstract translation: 目的：提供含有石斛仁的组合物，以预防，缓解或治疗PPAR活化调节相关疾病，包括肥胖，代谢疾病和心血管疾病。 构成：用于预防或治疗PPAR活化调节相关疾病的组合物含有石斛石斛作为活性成分。 用于预防或治疗PPAR活化调节相关疾病的健康功能性食品的组合物含有石斛兰作为活性成分。 石斛石斛被用作粉状石斛，其干燥物，或使用选自水，C1-C4醇及其组合的溶剂制备的粗提取物。 C1-C4醇是甲醇或乙醇。 石斛也用作由粗提取物使用正己烷，二氯甲烷或乙酸乙酯制备的级分。 （附图标记）（AA）相对值（％）; （BB）无治疗组，曲格列酮; （CC）实施例<1-1>; （DD）实施例<1-2>; （EE）实施例<2> n-Hx; （FF）实施例<2> MC; （GG）实施例 EA; （HH）实施例<3> fr2; （II）实施例<3> fr3; （JJ）实施例<3> fr2-2; （KK）实施例<3> fr2-5; （LL）实施例<3>化合物1; （MM）实施例3化合物2; （NN）实施例3化合物3; （OO）实例<3>化合物4