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公开(公告)号：KR100936276B1
公开(公告)日：2010-01-13
申请号：KR1020070107774
申请日：2007-10-25
Applicant: 한국과학기술원
Abstract: 본 발명은 미세유체제어기술 기반으로 난관의 물리적 특징 및 생물적 특징을 모방한 수정란 및 난자 배양 시스템에 관한 것으로, 구체적으로 난관에서의 압축, 연동운동 및 섬모운동을 모방할 수 있는 장치를 미세유체제어기술과 조합함으로써 수정란 및 난자의 배양 및 발달을 효율적으로 하기 위한 방법을 제공하는 것이다. 본 발명에 의한 미세유체제어기술을 기반으로 한 난관 생체모방 수정란 배양 시스템은 수정란 및 난자의 효율적인 배양 및 발달을 도울 수 있기 때문에 줄기세포 및 발생학 연구의 편의성 및 높은 효율성을 제공하고, 일반 산부인과에서도 효과적으로 불임부부를 위한 인공수정 및 체외수정에 응용될 수 있다.
미세유체제어기술, 수정란 배양, 배양 시스템, 난관, 압축, 연동운동, 섬모운동-
公开(公告)号：KR100931303B1
公开(公告)日：2009-12-11
申请号：KR1020080126356
申请日：2008-12-12
Applicant: 한국과학기술원
Abstract: PURPOSE: A microfluidic chip for the alignment and separation of microparticles is provided to drive microparticles by electrodynamics principle by forming an ununiform electric field inside a microfluidic channel, thereby reducing remarkably the time required for the manufacturing a device. CONSTITUTION: A microfluidic chip(100) for the alignment and separation of microparticles comprises a power device(110); a first electrode(120) which is electrically connected with the one end of the power device so as to allow the drive voltage to be applied from the power device; a first substrate(140) which is attached to the first electrode; a second electrode(130) which faces with the first electrode and is electrically connected with the other end of the power device so as to allow the reference voltage to be applied from the power device; a second substrate(150) which faces the first substrate, and is attached to the second electrode; a microfluidic channel(160) which is formed the first electrode and the second electrode and where a sample is located; and a spacer(180) which is located between the first electrode and the second electrode to separate the first electrode and the second electrode. The second electrode and the second substrate are inclined.
Abstract translation: 目的：提供用于微粒对准和分离的微流体芯片，通过在微流体通道内形成不均匀的电场，通过电动力学原理驱动微粒，从而显着减少制造器件所需的时间。 构成：用于微粒对准和分离的微流体芯片（100）包括功率器件（110）; 第一电极（120），其与所述功率器件的一端电连接以允许从所述功率器件施加所述驱动电压; 第一基板（140），其附接到所述第一电极; 与所述第一电极相对并与所述功率器件的另一端电连接的第二电极（130），以允许从所述功率器件施加所述参考电压; 第二基板（150），其面向所述第一基板，并且附接到所述第二电极; 微流体通道（160），其形成在第一电极和第二电极之间并且样品位于其中; 以及位于第一电极和第二电极之间以分离第一电极和第二电极的间隔物（180）。 第二电极和第二基板倾斜。
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33.发明公开자기영동 기반의 생체 분자 다중검출 미세 유체 칩 및 이를이용한 생체 분자 분석장치 및 분석방법 失效MAGNETOPHORETIC MULTIPLEXED MICROFLUIDIC CHIP AND ASSAY SYSTEM AND METHOD FOR ANALYSIS OF BIOMOLECULES USING THE CHIP
公开(公告)号：KR1020090112342A
公开(公告)日：2009-10-28
申请号：KR1020080038176
申请日：2008-04-24
Applicant: 한국과학기술원
IPC: G01N35/00
Abstract: PURPOSE: A biomolecule multi-detection microfluid chip of magnetophoretic base is provided to widen the width of biomolecule multi-detection and miniaturize analysis device. CONSTITUTION: A biomolecule multi-detection microfluid chip (100) of magnetoelectrophoretic base comprises a reactant injection unit (110), focusing solution injection unit (120), reactant focusing unit (130), color microbead reference unit (150), color microbead injection (140), decoding and position determining unit (160), magnetic field focusing (170), and discharging unit (180). The reactant focusing unit collects the reactant. The color microbead reference unit injects reference color microbead for decoding color microbead. The decoding & position determining unit is exposed to magnetic field and decodes color microbead.
Abstract translation: 目的：提供生物分子多重检测微流体芯片，用于拓宽生物分子多重检测和小型化分析装置的宽度。 构成：磁电泳基体的生物分子多重检测微流体芯片（100）包括反应物注入单元（110），聚焦溶液注入单元（120），反应物聚焦单元（130），彩色微珠参考单元（150），彩色微珠注入 （140），解码和位置确定单元（160），磁场聚焦（170）和放电单元（180）。 反应物聚集单元收集反应物。 彩色微珠参考单元注入参考色微珠，用于解码彩色微珠。 解码位置确定单元暴露于磁场并解码彩色微珠。
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公开(公告)号：KR1020090092467A
公开(公告)日：2009-09-01
申请号：KR1020080017720
申请日：2008-02-27
Applicant: 한국과학기술원
Abstract: A microfluid processing unit controlled with the light and a method thereof are provided to select a unit getting hot and the other unit, non hot, and to increase the resolution. A microfluid processing unit comprises a minute electric heat generating unit(10), an optical source unit(20), and a uniticle driving unit(30). The minute electric heat generating unit makes the current flow with the light on or off. The minute electric heat generating unit is comprised of an array of the photoconductivity resistance. The minute electric heat generating unit includes anode and cathode to supply the electricity to the array of the resistance. The optical source unit controls the pattern of the light applied with the location in which the light is applied in the minute electric heat generating unit.
Abstract translation: 提供用光控制的微流体处理单元及其方法，以选择单元变热，而另一单元非热，并提高分辨率。 微流体处理单元包括微小电热产生单元（10），光源单元（20）和unit粒驱动单元（30）。 微型电热发生单元使电流流过，导通或关闭。 分电热产生单元由光导电阻的阵列组成。 分电热产生单元包括阳极和阴极，以向电阻阵列供电。 光源单元控制在微小电热发生单元中施加有光的位置的光的图案。
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公开(公告)号：KR1020090059837A
公开(公告)日：2009-06-11
申请号：KR1020070126893
申请日：2007-12-07
Applicant: 한국과학기술원
IPC: G01N35/00
CPC classification number: B03C1/32 , B01L3/502761 , B03C1/288 , B03C2201/18 , Y10T436/25375
Abstract: An apparatus and a method for separating particles by using isomagnetophoresis are provided to analyze and separate particles regardless of the size of particles with high reliability. An apparatus for separating particles by using isomagnetophoresis comprises an injection hole(203) which contains fluids having different magnetic susceptibility and is injected with predetermined minute particles; a microfluidic channel(205) flowing the injected fluids and the injected microfluids; a magnetic energy source(207) authorizing a magnetic field to a vertical direction of the microfluidic channel; and a discharge hole(206) discharging minute particles passing through the microfluidic channel.
Abstract translation: 提供了使用等离子体蒸气分离颗粒的装置和方法，以分析和分离颗粒，而不管具有高可靠性的颗粒尺寸。 通过使用等离子体蒸气分离颗粒的装置包括：注入孔（203），其包含不同磁化率的流体并注射预定的微小颗粒; 使注入的流体和注射的微流体流动的微流体通道（205） 磁能源（207），其授权对所述微流体通道的垂直方向的磁场; 以及排出通过微流体通道的微小颗粒的排出孔（206）。
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Patent Agency Ranking36.发明公开
公开(公告)号：KR1020090041962A
公开(公告)日：2009-04-29
申请号：KR1020070107774
申请日：2007-10-25
Applicant: 한국과학기술원
Abstract: A culture system for fertilized egg or ovum using micro-fluid mechanics is provided to improve culture of fertilized egg and ovum, thereby being used for artificial insemination and external fertilization for infertility couples. A culture system for fertilized egg or ovum comprises: an inlet(1) for fertilized egg or ovum; an ovum movement micro-fluidic channel(10), linked with the inlet, in which ovum can move; a plurality of ovum compression micro-fluidic channels(20) formed by reducing diameter of the ovum movement micro-fluidic channel; and an outlet(60) for fertilized egg or ovum connected to the ovum movement micro-fluidic channel.
Abstract translation: 提供使用微量流体力学的受精卵或卵的培养系统，以改善受精卵和卵子的培养，从而用于不育夫妇的人工授精和外受精。 受精卵或卵子的培养系统包括：受精卵或卵子的入口（1） 与入口连接的卵移动微流体通道（10），卵子可移动; 通过减小卵移动微流体通道的直径形成的多个卵压缩微流体通道（20）; 以及用于受精卵或卵的出口（60），其连接到所述卵移动微流体通道。
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公开(公告)号：KR100892905B1
公开(公告)日：2009-04-15
申请号：KR1020080017721
申请日：2008-02-27
Applicant: 한국과학기술원
CPC classification number: G02F1/0072 , B01L9/527 , B05C5/0291
Abstract: A droplet actuating apparatus and an actuating method thereof are provided to actuate the droplets by an SAW(surface acoustic wave) through the optic-acoustic effect, and quickly realize a new Lap-on-a-chip based on the droplets. A light source driving unit(10) generates the light of a repeated pulse shape and has a function of controlling the intensity of the generated light, the pulse duration and pulse repetition frequency. An optical location controller(20) receives the light generated from the light source driving unit and radiates the light to a location where the droplet(33) to be actuated exists. A droplet actuator(30) generates an SAW based on the optic-acoustic effect by the light radiated from the optical location controller, and actuates the droplet by using the SAW. A pulse light generator(11) generates the light of a pulse shape. A collimator(12) makes the generated pulse light into the parallel light.
Abstract translation: 提供液滴驱动装置及其致动方法以通过声 - 声效应通过SAW（声表面波）致动液滴，并且基于液滴快速实现新的片上片。 光源驱动单元（10）产生重复脉冲形状的光，并且具有控制所产生的光的强度，脉冲持续时间和脉冲重复频率的功能。 光学位置控制器（20）接收从光源驱动单元产生的光，并将光照射到要被致动的液滴（33）的位置。 液滴致动器（30）基于通过从光学位置控制器辐射的光的光声效应产生SAW，并且通过使用SAW致动液滴。 脉冲光发生器（11）产生脉冲形状的光。 准直器（12）使产生的脉冲光进入平行光。
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公开(公告)号：KR100891487B1
公开(公告)日：2009-04-01
申请号：KR1020070110988
申请日：2007-11-01
Applicant: 한국과학기술원
Abstract: An enucleation system of oocyte or ovum based on microfluid mechanics and an enucleation method of oocyte or ovum using the same are provided to perform single cells manipulation and to perform automatically and efficiently the enucleation of oocyte or ovum and to ensure high convenience and effectiveness of the stem cell and embryology research. An enucleation system of oocyte or ovum comprises oocyte or ovum culture medium and reagent inlet port(1); a microfluid channel part(7); and an envelope incision microfluidic channel part(10) reducing the diameter of an ovum movement microfluidic channel part; an ovum squeeze microfluidic channel part(16); an enucleated oocyte or the ovum vent(50); and a necleus vent(51) separated from oocyte or ovum.
Abstract translation: 提供基于微流体力学的卵母细胞或卵的摘除系统和使用其的卵母细胞或卵的摘除方法，以执行单细胞操作并自动和有效地执行卵母细胞或卵子的摘除，并确保高效的方便和有效性 干细胞和胚胎学研究。 卵母细胞或卵子的摘除系统包括卵母细胞或卵子培养基和试剂入口（1）; 微流体通道部分（7）; 和包膜切口微流体通道部分（10），其减小卵移动微流体通道部分的直径; 卵子挤压微流体通道部分（16）; 去核卵母细胞或排卵孔（50）; 和从卵母细胞或卵子分离出的心脏通气口（51）。
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公开(公告)号：KR100885678B1
公开(公告)日：2009-02-26
申请号：KR1020070073910
申请日：2007-07-24
Applicant: 한국과학기술원
IPC: G01N33/00
Abstract: 본 발명은 기체 측정 장치 및 방법에 관한 것으로서, 특히 고분자 구조의 물질을 이용하여 기체 측정의 용이성 및 휴대성을 높일 수 있고, 제품에서 발생하는 기체를 측정하여 제품의 이상 여부를 판단할 수 있으며, 기체량이 미소할 경우, 외부 압력만으로 흡입 과정을 실시하여 지시 용액과 반응률을 높여 기체를 측정할 수 있는 기체 측정 장치 및 방법을 제공하는 것을 목적으로 한다.
그 기술적 구성은 기체와 반응하여 기체를 판별할 수 있는 지시 용액이 주입되도록 요홈 형상으로 형성되는 지시 용액 주입부와, 상기 지시 용액 주입부로 주입된 지시 용액이 수용될 수 있도록 상기 지시 용액 주입부와 연결되되, 요홈 형상으로 형성된 지시 용액 수용부를 포함하는 제1 기판; 상기 요홈이 형성된 제1 기판의 일면에 부착되어 상기 지시 용액이 이동 및 수용될 수 있는 유로가 형성되고, 기체가 유입되어 상기 제1 기판의 지시 용액과 반응할 수 있도록 형성되는 제2 기판; 을 포함하며 이루어지는 것을 특징으로 한다.
기체 측정, 판별, 지시 용액, PDMS, 휴대 장치, 제품 상태 판별-
公开(公告)号：KR1020080104751A
公开(公告)日：2008-12-03
申请号：KR1020070051974
申请日：2007-05-29
Applicant: 한국과학기술원
IPC: B81B1/00
Abstract: An apparatus and a method for driving microfluid using a light-emitting element are provided to form a protective layer for preventing electrolysis on a photoconductive layer so as to minimize damages due to electrolysis. An apparatus for driving microfluid using a light-emitting element includes a light-emitting element(10) emitting a laser beam, a photoconductive layer(30) having a region to which the laser beam is irradiated and a voltage is applied, a reference electrode layer(40) for forming an electric potential in the photoconductive layer, a microfluid flow channel(50) through which microfluid or particles(51) in the microfluid are moved with the voltage applied to the photoconductive layer, and a voltage supply unit(60) connected to the photoconductive layer and the reference voltage layer to apply a voltage thereto.
Abstract translation: 提供使用发光元件驱动微流体的装置和方法，以形成用于防止光电导层上的电解的保护层，从而最小化由于电解造成的损伤。 使用发光元件驱动微流体的装置包括发射激光的发光元件（10），具有照射激光束的区域和施加电压的光电导层（30），参考电极 用于在光电导层中形成电位的层（40），微流体通道（50），微流体中的微流体或微粒（51）通过施加到光电导层的电压而移动，以及电压供应单元 ）连接到光电导层和参考电压层以向其施加电压。
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