MICRONEEDLE DEVICES AND METHODS
    38.
    发明公开
    MICRONEEDLE DEVICES AND METHODS 有权
    MICRONEEDLE设备和方法

    公开(公告)号:EP2683358A1

    公开(公告)日:2014-01-15

    申请号:EP12709231.0

    申请日:2012-03-06

    Abstract: A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

    Abstract translation: 1。一种医疗装置,包括:微针阵列和布置在所述微针上的涂层,其中所述涂层包括:选自利多卡因,丙胺卡因及其组合的局部麻醉剂; 和选自α1肾上腺素能激动剂,α2肾上腺素能激动剂及其组合的局部麻醉剂量延长组分; 其中所述局部麻醉剂以基于涂层中固体总重量的至少1重量%的量存在,并且其中剂量增加组分/局部麻醉剂重量比至少为0.0001; 包括可溶解微针阵列的医疗装置,所述微针包括:可溶解基质材料; 至少1重量%的选自利多卡因,丙胺卡因及其组合的局部麻醉剂; 和选自α1肾上腺素能激动剂,α2肾上腺素能激动剂及其组合的局部麻醉剂量延长组分; 其中所述剂量延长组分/局部麻醉剂重量比至少为0.0001,并且其中wt-%基于含有所述局部麻醉剂的所述可溶解微针的所有部分中的固体总重量; 使用所述装置在哺乳动物组织中延长局部递送的局部麻醉剂量的方法; 并提供了制造这些装置的方法。

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