公开(公告)号：WO2008024188A8

公开(公告)日：2008-07-03

申请号：PCT/US2007017340

申请日：2007-08-03

Applicant: ABBOTT LAB ,  WU CHENGBIN ,  GHAYUR TARIQ ,  DIXON RICHARD W ,  SALFELD JOCHEN G

Inventor： WU CHENGBIN ,  GHAYUR TARIQ ,  DIXON RICHARD W ,  SALFELD JOCHEN G

IPC: A61K51/00 ,  C07H21/04 ,  C12N1/18 ,  C12N1/21 ,  C12N5/06 ,  C12P21/06

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/42 ,  A61K47/48384 ,  A61K47/6803 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/24 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/2809 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/40 ,  C07K16/46 ,  C07K16/467 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/76

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及它们在预防和/或治疗急性和慢性炎症和其他疾病中的用途。

公开(公告)号：WO2011163478A4

公开(公告)日：2012-07-05

申请号：PCT/US2011041633

申请日：2011-06-23

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  JAKWAY JAMES J ,  TALANIAN ROBERT V ,  BENATUIL LORENZO

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  JAKWAY JAMES J ,  TALANIAN ROBERT V ,  BENATUIL LORENZO

IPC: A61K39/395 ,  C07K16/00 ,  C12P21/02

CPC classification number: C07K16/2875 ,  C07K16/241 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/64

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

公开(公告)号：WO2012088290A2

公开(公告)日：2012-06-28

申请号：PCT/US2011066530

申请日：2011-12-21

Applicant: ABBOTT LAB ,  WU CHENGBIN ,  YING HUA ,  GHAYUR TARIQ ,  GOODREAU CARRIE ,  BARDWELL PHILIP

Inventor： WU CHENGBIN ,  YING HUA ,  GHAYUR TARIQ ,  GOODREAU CARRIE ,  BARDWELL PHILIP

IPC: A61K39/395 ,  A61P37/04 ,  C07K16/24 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/13 ,  C12N15/63 ,  C12P21/00 ,  G01N33/53

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/244 ,  C07K16/26 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/56 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/525 ,  G01N2333/54 ,  G01N2405/00

Abstract: The present invention provides engineered multivalent and multispecific binding proteins, as well as methods of making them. Methods for using the multivalent and multispecific binding proteins of the invention in the prevention, diagnosis, and/or treatment of disease are also provided.

Abstract translation: 本发明提供工程化的多价和多特异性结合蛋白，以及制备它们的方法。 还提供了在预防，诊断和/或治疗疾病中使用本发明的多价和多特异性结合蛋白的方法。

公开(公告)号：WO2012018790A3

公开(公告)日：2012-05-31

申请号：PCT/US2011046233

申请日：2011-08-02

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN ,  ISAKSON PETER C

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN ,  ISAKSON PETER C

IPC: C07K16/00

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  A61K49/00 ,  A61K51/1021 ,  C07K16/241 ,  C07K16/245 ,  C07K16/468 ,  C07K2317/35 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/53 ,  G01N33/56966 ,  G01N33/6857 ,  G01N33/6869 ,  G01N2333/54 ,  G01N2333/545 ,  G01N2800/24 ,  G01N2800/7028

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.

公开(公告)号：WO2012006490A3

公开(公告)日：2012-04-26

申请号：PCT/US2011043297

申请日：2011-07-08

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  LIU JUNJIAN

Inventor： GHAYUR TARIQ ,  LIU JUNJIAN

IPC: A61K39/00 ,  C12N5/07 ,  C12N5/16 ,  C12P21/08

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6845 ,  C07K16/22 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6872

Abstract: Methods of making engineered multivalent and multi-specific binding proteins, and using the binding proteins in the prevention, diagnosis, and/or treatment of disease are provided. The multivalent binding proteins may contain more than one linked heavy chain and/or light chain variable regions joined by a constant region to an Fc region. The multivalent binding proteins may bind to a number of cytokines, hormones, growth factors, small molecules or cell surface receptors, including NGF and any of a number of small molecules, growth factors, cytokines, hormones or cell surface receptors.

Abstract translation: 提供了制造工程化多价和多特异性结合蛋白的方法，并且使用该结合蛋白预防，诊断和/或治疗疾病。 多价结合蛋白可含有超过一个连接的重链和/或轻链可变区，其通过恒定区连接至Fc区。 多价结合蛋白可以结合许多细胞因子，激素，生长因子，小分子或细胞表面受体，包括NGF和许多小分子，生长因子，细胞因子，激素或细胞表面受体中的任何一种。

公开(公告)号：WO2011059755A3

公开(公告)日：2011-07-28

申请号：PCT/US2010054521

申请日：2010-10-28

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  SALFELD JOCHEN G ,  MCPHERSON MICHAEL J ,  HARRIS MARIA C ,  LIU JUNJIAN ,  ISAKSON PETER C ,  GU JIJIE

Inventor： GHAYUR TARIQ ,  SALFELD JOCHEN G ,  MCPHERSON MICHAEL J ,  HARRIS MARIA C ,  LIU JUNJIAN ,  ISAKSON PETER C ,  GU JIJIE

IPC: C07K16/00 ,  A61K39/395

CPC classification number: C07K16/241 ,  C07K16/22 ,  C07K16/2803 ,  C07K16/2875 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/31 ,  C07K2317/73

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：WO2011050262A3

公开(公告)日：2011-06-30

申请号：PCT/US2010053730

申请日：2010-10-22

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  MORGAN-LAPPE SUSAN E ,  REILLY EDWARD B ,  KINGSBURY GILLIAN A ,  PHILLIPS ANDREW ,  WANG JIEYI ,  BELL RANDY L ,  NORVELL SUZANNE M ,  LI YINGCHUN ,  LIU JUNJIAN ,  YING HUA ,  LIU ZHIHONG

Inventor： GHAYUR TARIQ ,  MORGAN-LAPPE SUSAN E ,  REILLY EDWARD B ,  KINGSBURY GILLIAN A ,  PHILLIPS ANDREW ,  WANG JIEYI ,  BELL RANDY L ,  NORVELL SUZANNE M ,  LI YINGCHUN ,  LIU JUNJIAN ,  YING HUA ,  LIU ZHIHONG

IPC: C12P21/08

CPC classification number: C07K16/22 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：WO2010127294A2

公开(公告)日：2010-11-04

申请号：PCT/US2010033246

申请日：2010-04-30

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  BROPHY SUSAN E ,  DEVARE SUSHIL G ,  GRENIER FRANK C ,  MOORE JEFFREY A ,  RUAN QIAOQIAO ,  TETIN SERGEY Y ,  STEINHAUS JENNIFER M ,  LIU JUNJIAN ,  ALI SALMAN ,  SYED HINA N

Inventor： GHAYUR TARIQ ,  BROPHY SUSAN E ,  DEVARE SUSHIL G ,  GRENIER FRANK C ,  MOORE JEFFREY A ,  RUAN QIAOQIAO ,  TETIN SERGEY Y ,  STEINHAUS JENNIFER M ,  LIU JUNJIAN ,  ALI SALMAN ,  SYED HINA N

IPC: A61K39/395 ,  C12P21/06

CPC classification number: C07K16/18 ,  C07K16/1045 ,  C07K16/244 ,  C07K16/26 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/00

Abstract: Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 工程化的多价和多特异性结合蛋白，制备方法，特别是其在预防，诊断和/或治疗疾病中的用途。

公开(公告)号：WO2009149185A3

公开(公告)日：2010-03-04

申请号：PCT/US2009046130

申请日：2009-06-03

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  HAHN ALFRED ,  MUELLER BERNHARD

Inventor： GHAYUR TARIQ ,  HAHN ALFRED ,  MUELLER BERNHARD

IPC: C07K16/20 ,  C07K16/46 ,  C12P21/08

CPC classification number: C07K16/2869 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6843 ,  A61K47/6845 ,  A61K47/6849 ,  C07K16/18 ,  C07K16/22 ,  C07K16/241 ,  C07K16/244 ,  C07K16/245 ,  C07K16/248 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2887 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/53 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6863 ,  G01N2333/525

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

公开(公告)号：WO2009134776A3

公开(公告)日：2009-12-23

申请号：PCT/US2009041945

申请日：2009-04-28

Applicant: ABBOTT LAB ,  GHAYUR TARIQ ,  MORGAN-LAPPE SUSAN E ,  REILLY EDWARD B ,  KINGSBURY GILLIAN A ,  PHILLIPS ANDREW ,  WANG JIEYI ,  BELL RANDY L ,  NORVELL SUZANNE M ,  LI YINGCHUN ,  LIU JUNJIAN ,  YING HUA

Inventor： GHAYUR TARIQ ,  MORGAN-LAPPE SUSAN E ,  REILLY EDWARD B ,  KINGSBURY GILLIAN A ,  PHILLIPS ANDREW ,  WANG JIEYI ,  BELL RANDY L ,  NORVELL SUZANNE M ,  LI YINGCHUN ,  LIU JUNJIAN ,  YING HUA

IPC: A61K39/00

CPC classification number: C07K16/468 ,  A61K39/39533 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/6872 ,  G01N33/74 ,  G01N2333/515 ,  G01N2333/705 ,  Y10S435/81

Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及它们在疾病的预防，诊断和/或治疗中的用途。