公开(公告)号：EP0712497B1

公开(公告)日：2001-11-07

申请号：EP94927907.9

申请日：1994-08-01

Applicant: Abbott Laboratories

Inventor： ADAMCZYK, Maciej ,  CHEN, Yon-Yih ,  WALLING, John, A. ,  JAMES, Bryan, D. ,  ARTRIP, Sharon, G.

IPC: G01N33/74 ,  G01N33/531 ,  G01N33/58 ,  C07K16/24 ,  C07J1/00 ,  A61K31/565 ,  A61K31/58

CPC classification number: G01N33/53 ,  C07J1/0022 ,  C07K16/26 ,  G01N33/743 ,  Y02P20/55 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/968 ,  Y10S436/817 ,  Y10S436/822 ,  Y10S530/812

Abstract: The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reagents and methods for synthesizing these reagents. The immunoassays are preferably microparticle enzyme immunoassays (MEIAs) and fluorescence polarization immunoassays (FPIAs). Further discloded are novel starting materials for making the above novel immunogens and labeled reagents. Methods for making the novel immunogens and labeled reagents from the novel starting materials are also disclosed.

公开(公告)号：EP1121599A1

公开(公告)日：2001-08-08

申请号：EP99956580.7

申请日：1999-10-15

Applicant: ABBOTT LABORATORIES

Inventor： ADAMCZYK, Maciej ,  BRATE, Elaine, M. ,  PERKOWITZ, Mary, M. ,  REGE, Sushil, D.

IPC: G01N33/58 ,  G01N33/531 ,  C07K16/14

CPC classification number: C07K16/44 ,  G01N33/533 ,  G01N33/9446

Abstract: Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of Figure 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of Figure 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.

公开(公告)号：EP0819254A1

公开(公告)日：1998-01-21

申请号：EP96911523.0

申请日：1996-04-01

Applicant: Abbott Laboratories

Inventor： ADAMCZYK, Maciej ,  BRATE, Elaine, M. ,  PERKOWITZ, Mary, M. ,  REGE, Sushil, D.

IPC: G01N33 ,  C07K16 ,  C12N5 ,  C12N15 ,  C12P21

CPC classification number: C07K16/44 ,  G01N33/533 ,  G01N33/9446 ,  Y10T436/10

Abstract: Immunoassay reagents, methods and test kits for the specific quantification of vancomycin in a test sample are disclosed. The reagent comprises antibodies prepared with immunogens of Figure 6 wherein P is an immunogenic carrier material and X is a linking moiety. Also described is the synthesis of labeled reagents of Figure 8 wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and X is a linking moiety.

公开(公告)号：EP0712497A1

公开(公告)日：1996-05-22

申请号：EP94927907.0

申请日：1994-08-01

Applicant: Abbott Laboratories

Inventor： ADAMCZYK, Maciej ,  CHEN, Yon-Yih ,  WALLING, John, A. ,  JAMES, Bryan, D. ,  ARTRIP, Sharon, G.

IPC: C07J1 ,  C07K16 ,  G01N33

CPC classification number: G01N33/53 ,  C07J1/0022 ,  C07K16/26 ,  G01N33/743 ,  Y02P20/55 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/968 ,  Y10S436/817 ,  Y10S436/822 ,  Y10S530/812

Abstract: The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reagents and methods for synthesizing these reagents. The immunoassays are preferably microparticle enzyme immunoassays (MEIAs) and fluorescence polarization immunoassays (FPIAs). Further discloded are novel starting materials for making the above novel immunogens and labeled reagents. Methods for making the novel immunogens and labeled reagents from the novel starting materials are also disclosed.

公开(公告)号：EP0599935A1

公开(公告)日：1994-06-08

申请号：EP92917665.0

申请日：1992-07-29

Applicant: ABBOTT LABORATORIES

Inventor： ADAMCZYK, Maciej ,  JOHNSON, Donald ,  HARTTER, Darryl, E. ,  FISHPAUGH, Jeffrey, R.

IPC: C07C211 ,  C07C311 ,  C07D223 ,  C07D493 ,  C07K14 ,  C07K16 ,  C09K11 ,  G01N33

CPC classification number: C07D223/28 ,  G01N33/533 ,  G01N33/9466 ,  Y10S436/815 ,  Y10S436/816 ,  Y10S436/822 ,  Y10S436/823

Abstract: Des réactifs et des méthodes d'immunoanalyse pour la quantification spécifique de l'amitriptyline ou de la nortriptyline dans un échantillon de test sont décrits et utilisent des anticorps préparés avec les dérivés de l'amitriptyline ou de la nortriptyline de formule (III) dans laquelle, pour l'amitriptyline, R représente CH3 et, pour la nortriptyline, R représente H. La présente invention décrit également la synthèse de traceurs de fluorescéine uniques ayant la structure de formule (IV) et de formule (V) dans lesquelles, pour une immunoanalyse d'amitriptyline spécifique, W1 représente un hétéroatome lié à l'anneau aromatique en position 2 ou en position 3, et pour une immunoanalyse de nortriptyline spécifique, W2 représente deux hétéroatomes liés ensemble et rattachés à l'anneau aromatique dans la position 2 ou dans la position 3, et dans lesquelles Q est une fraction détectable, de préférence la fluorescéine ou un dérivé de fluorescéine.

公开(公告)号：EP2507626A1

公开(公告)日：2012-10-10

申请号：EP10779443.0

申请日：2010-11-17

Applicant: Abbott Laboratories

Inventor： ADAMCZYK, Maciej ,  BRASHEAR, Roy Jeffrey ,  MATTINGLY, Phillip G.

IPC: G01N33/53

CPC classification number: G01N33/5306

Abstract: The present disclosure provides immunoassays and kits for detection or quantification of an protein of interest in a test sample that potentially contains endogenously produced autoantibodies reactive with the analyte.

公开(公告)号：EP2507625A1

公开(公告)日：2012-10-10

申请号：EP10782142.3

申请日：2010-11-17

Applicant: Abbott Laboratories

Inventor： ADAMCZYK, Maciej ,  BRASHEAR, Jeffrey, R. ,  MATTINGLY, Phillip, G.

IPC: G01N33/50 ,  G01N33/53

CPC classification number: G01N33/6878 ,  C07D219/14 ,  G01N33/56966 ,  G01N33/6893 ,  G01N2333/4712 ,  G01N2333/5412 ,  G01N2333/58 ,  G01N2800/325

Abstract: Assays are disclosed for diagnosing a clinical condition, assessing risk or predicting an outcome as a result of cardiac myocyte damage. Immunoassay methods and kits provide for the assessment of cardiac myocyte damage by determining the presence of multiple cardiac myocyte antigens in a test sample, and combining the multiple determinations in a single assay result.

公开(公告)号：EP2356458A1

公开(公告)日：2011-08-17

申请号：EP09756876.0

申请日：2009-10-22

Applicant: Abbott Laboratories

Inventor： ADAMCZYK, Maciej ,  BRASHEAR, Roy Jeffrey ,  MATTINGLY, Phillip G.

IPC: G01N33/564

CPC classification number: G01N33/564

Abstract: A method of determining the presence, amount or concentration of at least one autoantibody that reacts with neutrophil gelatinase-associated lipocalin (NGAL), alone or in further combination with a method of determining the concentration of NGAL, which methods can further comprise diagnosing, prognosticating, or assessing the efficacy of a therapeutic/prophylactic treatment of a patient and, optionally, modifying the therapeutic/prophylactic treatment of the patient as needed to improve efficacy; a kit comprising at least one component for assaying a test sample for at least one autoantibody that reacts with NGAL and instructions for assaying; a method of isolating an autoantibody that reacts with NGAL; an isolated autoantibody that reacts with NGAL; and a method for determining the reliability of an NGAL assay result.

公开(公告)号：EP2097749A2

公开(公告)日：2009-09-09

申请号：EP07871173.6

申请日：2007-10-17

Applicant: ABBOTT LABORATORIES

Inventor： MATTINGLY, Phillip G ,  ADAMCZYK, Maciej ,  BRASHEAR, Roy Jeffrey ,  DOSS, Robert C

IPC: G01N33/53

CPC classification number: G01N33/6854 ,  G01N33/54326 ,  G01N33/564 ,  G01N2800/324 ,  G01N2800/325 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/25125

Abstract: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among other things to identify cardiac pathology, or risk thereof, in subjects who have an autoimmune disease or who are related to an individual with an autoimmune disease. In particular embodiments, the invention also provides a method of determining whether a subject having, or at risk for, a cardiac pathology is a candidate for immunosuppressive therapy or immunoabsorption therapy. The invention also provides kits and kit components that are useful for performing the methods of the invention.

公开(公告)号：EP0641440B1

公开(公告)日：2000-11-08

申请号：EP92917171.8

申请日：1992-07-29

Applicant: ABBOTT LABORATORIES

Inventor： ADAMCZYK, Maciej ,  FISHPAUGH, Jeffrey, R. ,  HRUSKA, Robert, E. ,  JOHNSON, Donald

IPC: G01N33/94 ,  C07D313/12 ,  G01N33/533 ,  C07K16/44

CPC classification number: C07D313/12 ,  G01N33/533 ,  G01N33/9466 ,  Y10S436/815

Abstract: Immunoassay methods and reagents for the quantification of total doxepins (i.e., E-doxepin, Z-doxepin, E-desmethyldoxepin, and Z-desmethyldoxepin) in a test sample are disclosed. The quantification of total doxepins is accomplished in an immunoassay employing antibodies and labeled reagents prepared with doxepin derivatives of formula (II), wherein Y-Z can be C=CH or N-CH2, R1 is a linking group, R2 can be H or CH3 and Q can be a detectable moiety or an immunogenic carrier material. The antibody reagent comprises antibodies which are capable of binding to total doxepins and which are produced with one or more immunogens prepared from the doxepin derivative of formula (II), and the labeled reagent is also prepared from the doxepin derivative of formula (II).