-
公开(公告)号:NO990667D0
公开(公告)日:1999-02-12
申请号:NO990667
申请日:1999-02-12
Applicant: BASF AG
Inventor: BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083 , C07K
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
-
公开(公告)号:HRP970441B1
公开(公告)日:2005-04-30
申请号:HRP970441
申请日:1997-08-11
Applicant: BASF AG
Inventor: BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , ZIERKE THOMAS , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K5/06 , C07K5/062 , C07K5/065 , A61K36/05
Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.
-
公开(公告)号:SK14222001A3
公开(公告)日:2002-07-02
申请号:SK14222001
申请日:2000-04-05
Applicant: BASF AG
Inventor: BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JURGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , C07K5/06
Abstract: The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.
-
公开(公告)号:BR0009653A
公开(公告)日:2002-01-08
申请号:BR0009653
申请日:2000-04-05
Applicant: BASF AG
Inventor: BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065 , A61K31/4427
Abstract: The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
-
公开(公告)号:NO20014875D0
公开(公告)日:2001-10-08
申请号:NO20014875
申请日:2001-10-08
Applicant: BASF AG
Inventor: BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61P7/02 , A61P9/06 , A61P9/10 , A61P25/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07B43/00 , C07K5/02 , C07K5/062 , C07K5/065 , C07K
Abstract: The present invention relates to prodrugs of pharmacologically active five-membered heterocyclic amidines from which are produced in vivo compounds which are competitive inhibitors of trypsin-like serine proteases, in particular thrombin and kininogenases such as kallikrein, to the preparation thereof and to the use thereof as medicines. The invention also relates to pharmaceutical compositions which comprise the prodrugs of the active compounds as ingredients, and to the use of the compounds as thrombin inhibitors, anticoagulants and as antiinflammatory agents.
-
公开(公告)号:NO20014807D0
公开(公告)日:2001-10-03
申请号:NO20014807
申请日:2001-10-03
Applicant: BASF AG
Inventor: BAUCKE DORIT , MACK HELMUT , SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , DELZER JUERGEN
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065 , C07D
Abstract: The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
-
公开(公告)号:AU735364B2
公开(公告)日:2001-07-05
申请号:AU3941797
申请日:1997-07-29
Applicant: BASF AG
Inventor: BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , ZIERKE THOMAS , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K5/06 , C07K5/062 , C07K5/065
Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.
-
公开(公告)号:CA2368830A1
公开(公告)日:2000-10-19
申请号:CA2368830
申请日:2000-04-05
Applicant: BASF AG
Inventor: SEITZ WERNER , HORNBERGER WILFRIED , BACKFISCH GISELA , MACK HELMUT , DELZER JURGEN , BAUCKE DORIT
IPC: C12N9/99 , A61K38/00 , A61K38/55 , A61K47/48 , A61P7/02 , A61P43/00 , C07B43/00 , C07D401/12 , C07K5/062 , C07K5/065 , A61K31/4427
Abstract: The present invention relates to prodrugs of general formula (I). The meanin g of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin , are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
-
公开(公告)号:AT196637T
公开(公告)日:2000-10-15
申请号:AT97934552
申请日:1997-07-29
Applicant: BASF AG
Inventor: BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
-
公开(公告)号:NO20003814L
公开(公告)日:2000-07-25
申请号:NO20003814
申请日:2000-07-25
Applicant: BASF AG
Inventor: BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61P1/18 , A61P7/02 , A61P11/06 , A61P17/04 , A61P19/02 , A61P27/16 , A61P29/00 , C07K5/06 , C07K5/065 , C07K5/08 , A61K38/06
Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.
-
-
-
-
-
-
-
-
-