公开(公告)号：DE19704273A1

公开(公告)日：1997-09-11

申请号：DE19704273

申请日：1997-02-05

Applicant: BASF AG

Inventor： TELES JOAQUIM HENRIQUE ,  EBEL KLAUS DR ,  ENDERS DIETER PROF DR ,  BREUER KLAUS

IPC: C07B53/00 ,  C07C45/00 ,  C07D249/08 ,  C07D249/10 ,  C07D405/04 ,  C07C45/72 ,  C07C49/14 ,  C07C49/82 ,  C07D249/16

Abstract: Preparation of optically active alpha-hydroxyketone derivatives of formula R-CHOH-CO-R (I) are prepared catalytically by benzoin condensation of aldehydes of formula RCHO (II) in the presence of a chiral triazolium carbene of formula (III). R = 1-30C aliphatic, cycloaliphatic, arylaliphatic, or aromatic; R1 = 1-30C alkyl or aryl (both optionally bonded by O, S or N), H, halo, CN, NO2 or 1-20C perhaloalkyl; R2, R3 = 1-30C alkyl or aryl; or R1+R3 complete a ring. R2 and/or R3 are chiral. (III) is preferably formed in situ, from a salt of formula (IV) or by elimination of HY from the triazoline of formula (V). X = anion;Y = group that can be lost as HY. (III), (IV) and (V) are new.