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公开(公告)号:ES2231925T3
公开(公告)日:2005-05-16
申请号:ES98114967
申请日:1998-08-10
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , HAREMZA SYLKE DR , SCHEHLMANN VOLKER DR , WESTENFELDER HORST , WUNSCH THOMAS DR , DROGEMULLER MICHAEL DR
IPC: A61K8/00 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K31/12 , A61K31/122 , A61K31/216 , A61K31/277 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C69/618 , C07C69/76 , C07C233/00 , C07C233/11 , C07C235/34 , A61K7/42 , C07C309/58 , C07C309/59 , C07C309/44 , C07C233/40 , C07C69/738 , A61K31/16 , A61K31/21 , A61K31/275
Abstract: UTILIZACION DE 4,4 - DIARILBUTADIENOS DE FORMULA I, EN DONDE LAS VARIABLES TIENEN EL SIGNIFICADO CITADO EN LA DESCRIPCION, COMO FILTROS FOTOESTABLES DE UV EN PREPARACIONES COSMETICAS Y FARMACEUTICAS PARA LA PROTECCION DE LA PIEL HUMANA O DE LOS CABELLOS HUMANOS CONTRA LOS RAYOS SOLARES, SOLOS O JUNTO CON PREPARACIONES COSMETICAS O FARMACEUTICAS YA CONOCIDAS, EN COMPUESTOS ABSORBENTES DEL INTERVALO DE UV.
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公开(公告)号:ES2217475T3
公开(公告)日:2004-11-01
申请号:ES98119094
申请日:1998-10-09
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , HAREMZA SYLKE DR , SCHEHLMANN VOLKER DR , WESTENFELDER HORST , WUNSCH THOMAS DR
IPC: A61K8/00 , A61K8/40 , A61K31/00 , A61P17/00 , A61P17/16 , A61Q1/04 , A61Q17/04 , A61K7/42 , A61K31/275
Abstract: Photo-stable ultraviolet (UV) filters for cosmetic or pharmaceutical use consist of substituted alpha -methyl-styrene derivatives (I). The use of substituted alpha -methyl-styrene derivatives of formula (I), optionally in combination with conventional UV absorbers, as photo-stable UV filters in cosmetic or pharmaceutical preparations for protecting human skin or hair against sunlight is new. R1 = 4-10C alkoxy, 1-12C alkylamino, 1-12C dialkylamino (sic) or a water-solublizing group selected from carboxylate, sulfonate and ammonium residues; R2 = H, 2-10C alkyl or 1-12C alkoxy; R3,R4 = COOR5, COR5, CONR5R6 or CN, R4 and R5 being the same; R5,R6 = H, 1-12C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted). Independent claims are given for: (1) the use of (I) as photostable UV-A filters; (2) the use of (I) as UV stabilizers; (3) cosmetic and pharmaceutical compositions for protecting human epidermis or skin against UV light in the 280-400 nm region, comprising a carrier containing (I) (as photostable UV filter) and optionally conventional UV absorbers; (4) (I) for use as medicaments; and (5) pharmaceutical preparations containing (I).
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公开(公告)号:ES2205680T3
公开(公告)日:2004-05-01
申请号:ES99122878
申请日:1999-11-18
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , WUNSCH THOMAS DR , WESTENFELDER HORST
IPC: A61K8/00 , A61K8/40 , A61Q17/00 , A61Q17/04 , C07C67/343 , C07C69/618 , C07C253/30 , C07C255/41 , C09K3/00 , A61K7/42
Abstract: New oligomeric 4,4-diarylbutadiene carboxylic acid ester or amide sunscreen compounds. Oligomeric 4,4-diarylbutadiene carboxylic acid esters or amides of formula (I) are new. R1, R2 = H; aliphatic-, cycloaliphatic-, aromatic- or araliphatic- group; or carboxylate, sulfonate or ammonium; R3 = aliphatic, cycloaliphatic, aromatic, araliphatic or heterocyclic group; carbonyl, sulfonyl, phosphonyl, carboxylic acid ester or CN; Y = O or N(R4); R4 = H or aliphatic-, cycloaliphatic-, aromatic-,araliphatic or heterocyclic group; m = 2-10; n = 1-3 X = the residue of a polyol with 2-10 OH groups (corresponding to m). Am Independent claim is included for preparation of (I).
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公开(公告)号:DK1008586T3
公开(公告)日:2003-11-10
申请号:DK99122878
申请日:1999-11-18
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , WUENSCH THOMAS DR , WESTENFELDER HORST
IPC: A61K8/00 , A61K8/40 , A61Q17/00 , A61Q17/04 , C07C67/343 , C07C69/618 , C07C253/30 , C07C255/41 , C09K3/00 , A61K7/42
Abstract: New oligomeric 4,4-diarylbutadiene carboxylic acid ester or amide sunscreen compounds. Oligomeric 4,4-diarylbutadiene carboxylic acid esters or amides of formula (I) are new. R1, R2 = H; aliphatic-, cycloaliphatic-, aromatic- or araliphatic- group; or carboxylate, sulfonate or ammonium; R3 = aliphatic, cycloaliphatic, aromatic, araliphatic or heterocyclic group; carbonyl, sulfonyl, phosphonyl, carboxylic acid ester or CN; Y = O or N(R4); R4 = H or aliphatic-, cycloaliphatic-, aromatic-,araliphatic or heterocyclic group; m = 2-10; n = 1-3 X = the residue of a polyol with 2-10 OH groups (corresponding to m). Am Independent claim is included for preparation of (I).
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公开(公告)号:AU4089900A
公开(公告)日:2000-12-21
申请号:AU4089900
申请日:2000-06-16
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , PRECHTL FRANK DR , WUNSCH THOMAS DR , WESTENFELDER HORST
IPC: C07D233/64 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/49 , A61K47/22 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07D239/70 , C07D263/56 , C07D277/64 , A61K31/498 , A61K31/538 , A61K31/5415 , A61K7/42
Abstract: Use of new and known bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. Also new is their use for the protection of plastics. Use of bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. R and R = CN; alkylcarbonyl; alkoxycarbonyl; aryloxycarbonyl; or optionally substituted aminocarbonyl; R = H; 1-20C alkyl; 3-20C cycloalkyl; or -CH2-CH2-SO3 M ; M = cation; X = -O-; -S-; or -N(R )-; Z' = group of formula (ii) or (iii): R = H; alkyl, cycloalkyl, alkoxy, cycloalkoxy, alkoxycarbonyl, alkyl-NH-CO-, (alkyl)2-NH-CO-, alkyl-NH- or (alkyl)2N- (each with up to 20C); CN; NH2; or SO3 M and more than 1 R can be present. Independent claims are also included for: (1) the use of compounds (I) as light screening agents for the protection of plastics; (2) (I; Z' = (iii); and (3) (I; Z' = (ii); R4 = R40; R1, R2 = R10, R20 respectively) R and R = CN or 2-10C alkoxycarbonyl optionally substituted with -(CH2)n-SO3 M ; R = H; CH3; or -(CH2)n-SO3 M ; R = H; 1-8C alkyl; 1-8C alkoxy; or -SO3 M ; n = 2 or 3; M = H or HN(R )(R )(R ) ; R -R = H lower alkyl optionally substituted with OH; or a metal cation; but at least one -(CH2)n-SO3 M or -SO3 M must be present.
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公开(公告)号:DE19755650A1
公开(公告)日:1999-04-22
申请号:DE19755650
申请日:1997-12-15
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , HAREMZA SYLKE DR , SCHEHLMANN VOLKER DR , WESTENFELDER HORST , WUENSCH THOMAS DR
IPC: A61K8/40 , A61K31/275 , A61Q1/04 , A61Q17/04 , A61K7/42
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公开(公告)号:DE19746654A1
公开(公告)日:1999-02-18
申请号:DE19746654
申请日:1997-10-22
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , HAREMZA SYLKE DR , SCHEHLMANN VOLKER DR , WESTENFELDER HORST , WUENSCH THOMAS DR , DROEGEMUELLER MICHAEL DR , BOMM VOLKER DR
IPC: A61K8/35 , A61K8/37 , A61K8/40 , A61K8/42 , A61K31/12 , A61K31/122 , A61K31/216 , A61K31/277 , A61Q1/04 , A61Q17/04 , C07C69/618 , C07C233/11 , C07C235/34 , A61K7/44 , A61K31/215
Abstract: The use of 4,4-diaryl-butadiene derivatives of formula (I), in which the diene system has Z,Z-, Z,E-, E,Z- or Z,Z-configuration (or a mixture of these), is claimed as photostable ultraviolet (UV) stabilisers in cosmetic or pharmaceutical preparations for protecting human skin against sunlight, (I) optionally being used in combination with known UV absorbers. R1,R2 = H; 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, mono- or di-(1-12C alkyl)-amino, aryl or heteroaryl (all optionally substituted); or water-solubilising substituents selected from carboxylate, sulphonate and ammonium; R3 = H or (all optionally substituted) COOR5, COR5, CONR5R6, CN, SO2R5, SO2OR5, P(O)(OR7)(OR8), 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl; R4 = as R3 but not H; R5-R8 = H or (all optionally substituted) 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 7-10C bicycloalkyl, 3-10C cycloalkenyl, 7-10C bicycloalkenyl, aryl or heteroaryl; or groups R3-R8 can together complete a 5- or 6-membered ring (optionally further fused). Also claimed are : (i) the use of (I) as photostable UV-A filters; (ii) the use of (I) as UV stabilisers in cosmetic and pharmaceutical compositions; (iii) cosmetic or pharmaceutical compositions for protecting the human epidermis or hair against UV light in the 280-400 nm region, comprising (I) and optionally known UV absorbers in a suitable carrier; (iv) (I) for use as medicament; and (v) pharmaceutical preparations containing (I).
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公开(公告)号:DE19712033A1
公开(公告)日:1998-09-24
申请号:DE19712033
申请日:1997-03-21
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , AUMUELLER ALEXANDER DR , SCHEHLMANN VOLKER DR , WESTENFELDER HORST , WUENSCH THOMAS DR , HAREMZA SYLKE DR
IPC: A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61Q1/04 , A61Q17/04 , C07C229/56 , C07C229/60 , C07C255/30 , C07C255/58 , C07D275/02 , C07D275/03 , C07D319/06 , A61K7/42 , A61K31/235 , A61K31/275 , A61K31/425
Abstract: Use of enamine derivatives of formula (R )(R NH)C=C(R )(R ) (I) as UV filters in cosmetic and pharmaceutical preparations for protection of hair or skin against sun-radiation, alone or in combination with UV absorbers is new: R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = COOR , COR , CONR R , CN, SO2R , SO2OR or P(=O)OR OR ; R = H, or optionally substituted aliphatic, cycloaliphatic, arylaliphatic or aromatic residue with up to 18C; R = optionally substituted 5-12C aromatic or heteroaromatic residue; and R , R = H or aliphatic, arylaliphatic, cycloaliphatic, or optionally substituted aromatic with up to 18C; or R -R together with their bonded carbon atoms may form a 5-6 membered ring which may be further annelated.
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