公开(公告)号：CA2371174A1

公开(公告)日：2000-11-02

申请号：CA2371174

申请日：2000-04-11

Applicant: BASF AG

Inventor： MULLER REINHOLD ,  KOCK MICHAEL ,  GRANDEL ROLAND ,  LUBISCH WILFRIED ,  SCHULT SABINE ,  HOGER THOMAS

IPC: C07D235/08 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/551 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/16 ,  C07D401/08 ,  C07D403/08 ,  C07D235/06

Abstract: The invention relates to a compound of formula (I) or (II), wherein A represents a saturated or mono-unsaturated carbocycle containing 3 to 8 carb on atoms which can also have a condensed benzol ring, whereby the rings can als o be substituted with one or two different or identical radicals; R1 represent s hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C1-C6 - alkyl, OH, nitro, CF3, CN, NR11R12, NH-CO-R13, O-C1-C4 alkyl; and R2 represents hydrogen, branched and unbranched C1-C6 alkyl, C1-C4 alkyl-phenyl . The invention also relates to the tautomeric forms, possible enantiomeric an d diastereomeric forms, possible cis-trans isomers on the rings in A and their prodrugs. The substituted benzimidazoles of general formulas (I) and (II) ar e inhibitors of poly(ADP-ribose) polymerase (PARP), or poly(ADP-ribose) syntha se (PARS), as it is also known and can be used for the treatment or prophylaxis of diseases which are associated with the increased enzyme activity of this enzyme.