公开(公告)号：CA2371174C

公开(公告)日：2007-02-20

申请号：CA2371174

申请日：2000-04-11

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  HOGER THOMAS ,  KOCK MICHAEL ,  SCHULT SABINE ,  MULLER REINHOLD ,  GRANDEL ROLAND

IPC: C07D235/06 ,  C07D235/08 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/551 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/16 ,  C07D401/08 ,  C07D403/08

Abstract: The invention relates to a compound of formula (I) or (II), wherein A represents a saturated or mono-unsaturated carbocycle containing 3 to 8 carb on atoms which can also have a condensed benzol ring, whereby the rings can als o be substituted with one or two different or identical radicals; R1 represent s hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C1-C6 - alkyl, OH, nitro, CF3, CN, NR11R12, NH-CO-R13, O-C1-C4 alkyl; and R2 represents hydrogen, branched and unbranched C1-C6 alkyl, C1-C4 alkyl-phenyl . The invention also relates to the tautomeric forms, possible enantiomeric an d diastereomeric forms, possible cis-trans isomers on the rings in A and their prodrugs. The substituted benzimidazoles of general formulas (I) and (II) ar e inhibitors of poly(ADP-ribose) polymerase (PARP), or poly(ADP-ribose) syntha se (PARS), as it is also known and can be used for the treatment or prophylaxis of diseases which are associated with the increased enzyme activity of this enzyme.

公开(公告)号：NZ514930A

公开(公告)日：2003-10-31

申请号：NZ51493000

申请日：2000-04-11

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  RANDEL ROLAND ,  SCHULT SABINE ,  MULLER REINHOLD

IPC: C07D235/08 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/551 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/16 ,  C07D401/08 ,  C07D403/08 ,  C07D2 ,  C07D40

Abstract: Compounds of formula I, or formula II, wherein the variables are defined herein. The compounds are used in the manufacture of medicaments for the treatment of disorders mediated by the inhibition of the enzyme poly(ADP-ribose) polymerase or PARP.

公开(公告)号：HK1042084A1

公开(公告)日：2002-08-02

申请号：HK02103400

申请日：2002-05-04

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D ,  A61K ,  A61P

Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.

公开(公告)号：AU7656700A

公开(公告)日：2001-04-30

申请号：AU7656700

申请日：2000-09-15

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  MULLER REINHOLD ,  SCHULT SABINE

IPC: A61K31/5517 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D487/06 ,  C07D519/00 ,  C07D487/00

公开(公告)号：AU764216B2

公开(公告)日：2003-08-14

申请号：AU3034300

申请日：1999-11-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.

公开(公告)号：CA2408369A1

公开(公告)日：2002-11-07

申请号：CA2408369

申请日：2001-05-09

Applicant: BASF AG

Inventor： KOCK MICHAEL ,  GRANDEL ROLAND ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  HOGER THOMAS ,  SCHULT SABINE ,  MULLER REINHOLD

IPC: A61K31/404 ,  A61K31/496 ,  A61P3/10 ,  A61P7/00 ,  A61P9/08 ,  A61P9/10 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/10 ,  C07D209/14 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04

Abstract: The invention relates to novel indole derivatives, to the production thereof and to the use thereof as inhibitors of the enzyme poly(ADP ribose)polymeras e or PARP (EC 2.4.2.30) for producing medicaments.

公开(公告)号：SK15962001A3

公开(公告)日：2002-06-04

申请号：SK15962001

申请日：2000-04-27

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  HOLZENKAMP UTA ,  SCHULT SABINE ,  MULLER REINHOLD

IPC: A61K31/415 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/16 ,  C07D235/20 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D235/18 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

Abstract: The present invention relates to novel benzimidazoles, their preparation and their use as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30) for producing drugs.

公开(公告)号：CZ20012373A3

公开(公告)日：2002-05-15

申请号：CZ20012373

申请日：2000-09-15

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: A61K31/55 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D487/06

Abstract: The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.

公开(公告)号：SK7142001A3

公开(公告)日：2001-12-03

申请号：SK7142001

申请日：1999-11-23

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  SCHULT SABINE ,  GRANDEL ROLAND ,  MULLER REINHOLD

IPC: A61K20060101 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/496 ,  A61P20060101 ,  A61P3/12 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D235/30 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04

Abstract: Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4 - to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.

公开(公告)号：AU4054201A

公开(公告)日：2001-08-14

申请号：AU4054201

申请日：2001-01-25

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  MULLER REINHOLD ,  SCHULT SABINE

IPC: C07D471/04 ,  A61K31/437 ,  A61P25/00

Abstract: The invention relates to compounds of the formula I and the tautomeric forms, possible enantiomeric and diasteromeric forms thereof, and prodrugs thereof, and use thereof as PARP inhibitors.