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公开(公告)号：RO119783B1
公开(公告)日：2005-03-30
申请号：RO9702254
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: The invention relates to dolastatine derivatives having the chemical structure corresponding to the general formula: R1R2N-CHK-CO-A-B-D-E-(F)t-K to a pharmaceutical composition comprising a therapeutically efficient quantity of dolastatine derivative and a pharmaceutically acceptable carrier and to the use of a dolastatine derivative for preparing a pharmaceutical composition for treating a tumour in a mammal.
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公开(公告)号：AU744019B2
公开(公告)日：2002-02-14
申请号：AU6694698
申请日：1998-03-09
Applicant: BASF AG
Inventor： ROMERDAHL CYNTHIA A
IPC: C07D251/30 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61P35/00 , C07D239/60 , C07D405/12 , C07D409/12
Abstract: This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of Formula I or Formula Ia, as describe herein.
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公开(公告)号：SK282467B6
公开(公告)日：2002-02-05
申请号：SK165497
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Peptides of formula R1R2N-CHX-CO-A-B-D-E-(F)t-K (I) and their salts with acids are new. In the formula, R1 = Me, Et or iPr; R2 = H, Me or Et; or NR1R2 = a pyrrolidine ring; A = a valyl, isoleucyl, leucyl, 2-tert-butylglycyl, 2-ethylglycyl, norleucyl or norvalyl residue; B = a N-methyl-valyl, -leucyl, -isoleucyl, -norvalyl, -norleucyl, -2-tert-butylglycyl, -3-tert-butylalanyl or -2-ethylglycyl residue; D = a prolyl, 3,4-dehydroprolyl, 4-fluoroprolyl, 4,4-difluoroprolyl, azetidine-2-carbonyl, homoprolyl, thiazolidine-4-carbonyl or 3-, 4- or 5-methylprolyl residue; E = a 3,4-dehydroprolyl, 4-fluoroprolyl, 3- or 4-methylprolyl, 4,4-difluoroprolyl or azetidine-2-carbonyl residue; F = a valyl, 2-tert-butylglycyl, isoleucyl, leucyl, 2-cyclohexylglycyl, norleucyl, norvalyl, neopentylglycyl, alanyl, ~b-alanyl or aminoisobutyroyl residue; X = alkyl (pref. 2-5C alkyl), cyclopropyl or cyclopentyl; t = 0 or 1; and K = alkoxy (pref. 1-4C alkoxy), benzyloxy or opt. substd. amino.
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公开(公告)号：SK282466B6
公开(公告)日：2002-02-05
申请号：SK165397
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：AU734696B2
公开(公告)日：2001-06-21
申请号：AU6694698
申请日：1998-03-09
Applicant: BASF AG
Inventor： ROMERDAHL CYNTHIA A
IPC: C07D251/30 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61P35/00 , C07D239/60 , C07D405/12 , C07D409/12
Abstract: This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of Formula I or Formula Ia, as describe herein.
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Patent Agency Ranking
公开(公告)号：HU0002249A2
公开(公告)日：2001-05-28
申请号：HU0002249
申请日：1998-03-09
Applicant: BASF AG
Inventor： ROMERDAHL CYNTHIA A
IPC: C07D251/30 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61P35/00 , C07D239/60 , C07D405/12 , C07D409/12
Abstract: This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of Formula I or Formula Ia, as describe herein.
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公开(公告)号：PL323726A1
公开(公告)日：1998-04-14
申请号：PL32372696
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.
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公开(公告)号：MX9709146A
公开(公告)日：1998-03-31
申请号：MX9709146
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: La presente invencion se refiere a los compuestos novedosos de la formula: R1R2N-CHX-CO-A-B-D-E-(F)t-K, en donde R1, R2, A, B, D, E, F, K, X, y t tienen los significados mencionados en la descripcion y se describe la preparacion de éstos. Las sustancias novedosas tienen efecto antineoplástico.
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公开(公告)号：RO118953B1
公开(公告)日：2004-01-30
申请号：RO9702264
申请日：1996-06-03
Applicant: BASF AG
Inventor： HAUPT ANDREAS , EMLING FRANZ , ROMERDAHL CYNTHIA A
Abstract: The invention relates to peptide derivatives having the formula corresponding to the general structure I:
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公开(公告)号：SK125299A3
公开(公告)日：2001-12-03
申请号：SK125299
申请日：1998-03-09
Applicant: BASF AG
Inventor： ROMERDAHL CYNTHIA A
IPC: C07D251/30 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61P35/00 , C07D239/60 , C07D405/12 , C07D409/12
Abstract: This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of Formula I or Formula Ia, as describe herein.
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