公开(公告)号：DE58909539D1

公开(公告)日：1996-02-01

申请号：DE58909539

申请日：1989-09-12

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG ,  HOFMANN HANS ,  SZABO LASZLO ,  UNGER LILIANE ,  RASCHACK MANFRED

IPC: C07D243/08 ,  A61K31/495 ,  A61K31/55 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  C07D295/08 ,  C07D295/084 ,  C07D295/092

Abstract: PCT No. PCT/EP89/01058 Sec. 371 Date Mar. 18, 1991 Sec. 102(e) Date Mar. 18, 1991 PCT Filed Sep. 12, 1989 PCT Pub. No. WO90/03371 PCT Pub. Date Apr. 5, 1990.2-Hydroxy-3-phenoxy-propyl-substituted piperazines of the formula I I in which R1-R5, Y, m and n have the meaning indicated in the description, and the preparation thereof are described. The novel compounds are suitable for the therapy of oxygen deficiency diseases of the brain.

公开(公告)号：ZA9201866B

公开(公告)日：1993-09-13

申请号：ZA9201866

申请日：1992-03-13

Applicant: BASF AG

Inventor： TREIBER HANS-HOERG ,  HOFMANN HANS PETER ,  SZABO LASZLO

IPC: A61K31/495 ,  A61P9/00 ,  A61P9/10 ,  A61P25/28 ,  C07D213/57 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/185 ,  C07D333/24 ,  C07D ,  A61K

CPC classification number: C07D295/185 ,  C07D213/57 ,  C07D295/155 ,  C07D333/24

公开(公告)号：FI933883A

公开(公告)日：1993-09-06

申请号：FI933883

申请日：1993-09-06

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG ,  HOFMANN HANS PETER ,  SZABO LASZLO

IPC: A61K31/495 ,  A61P9/00 ,  A61P9/10 ,  A61P25/28 ,  C07D213/57 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/185 ,  C07D333/24

Abstract: PCT No. PCT/EP92/00488 Sec. 371 Date Sep. 14, 1993 Sec. 102(e) Date Sep. 14, 1993 PCT Filed Mar. 5, 1992 PCT Pub. No. WO92/16516 PCT Pub. Date Oct. 1, 1992.Compounds of the formula I where Ar, R1, R2, P and Q have the meanings indicated in the description, and the preparation thereof are described. The compounds have antihypoxic and antiischemic action and are suitable for treating acute and chronic degenerative processes of the CNS and other organs.

公开(公告)号：PL348920A1

公开(公告)日：2002-06-17

申请号：PL34892099

申请日：1999-12-24

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  KNOPP MONIKA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14 ,  A61K31/495

Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.

公开(公告)号：PL348916A1

公开(公告)日：2002-06-17

申请号：PL34891699

申请日：1999-12-22

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D275/06 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/55 ,  A61K31/551 ,  A61P9/10 ,  A61P25/28 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/428

Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.

公开(公告)号：CZ20012485A3

公开(公告)日：2002-04-17

申请号：CZ20012485

申请日：1999-12-24

Applicant: BASF AG

Inventor： STEINER GERD ,  ACHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  KNOPP MONIKA ,  SZABO LASZLO ,  EMLING FRANZ ,  HOFMANN HANS-PETER ,  GARCIA-LADONA FRANCISCO JAVIER ,  UNGER LILIANE

IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14 ,  A61K31/55

Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.

公开(公告)号：SK9682001A3

公开(公告)日：2002-03-05

申请号：SK9682001

申请日：1999-12-22

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D275/06 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/55 ,  A61K31/551 ,  A61P9/10 ,  A61P25/28 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/428

Abstract: The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for producing medicaments for the prophylaxis and therapy of cerebral ischaemia and strokes.

公开(公告)号：ID30022A

公开(公告)日：2001-11-01

申请号：ID20011717

申请日：1999-12-22

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  LADONA FRANSISCO JAVIER GARCIA ,  HOFMANN HANS PETER ,  UNGER LILIANE

IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14

Abstract: Use of pyrimidine derivatives of the formula Iwhere the substituents are as defined in the description, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.

公开(公告)号：NO20013408A

公开(公告)日：2001-08-21

申请号：NO20013408

申请日：2001-07-10

Applicant: BASF AG

Inventor： STEINLER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO-JAVIER ,  HOFMANN HANS PETER ,  UNGER LILIANE

IPC: C07D275/06 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/55 ,  A61K31/551 ,  A61P9/10 ,  A61P25/28 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/428

CPC classification number: A61K31/519 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/55

公开(公告)号：CA2359357A1

公开(公告)日：2000-07-20

申请号：CA2359357

申请日：2000-01-11

Applicant: BASF AG

Inventor： SZABO LASZLO ,  HOFMANN HANS-PETER ,  STEINER GERD ,  GARCIA-LADONA FRANCISCO JAVIER

IPC: G01N33/50 ,  A61K31/519 ,  A61K45/00 ,  A61P9/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P35/00 ,  C07D495/14 ,  G01N33/15 ,  G01N33/566 ,  A61K31/505

Abstract: The invention relates to the use of binding partners for 5-HT5-receptors in the treatment of neuropathological and in particular neurodegenerative and/or neuropsychiatric disturbances which can occur notably in cases of cerebral ischaemia, cerebral stroke, epilepsy and attacks in general, chronic schizophrenia, other psychotic illnesses, dementia, notably Alzheimer's disease, demyelination diseases, notably multiple sclerosis, and brain tumor s. The invention also relates to methods, especially screening methods, for identifying and characterizing such binding partners.