中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

51 records (took 0.022 seconds)

    Use of pyrimidine derivatives for the prophylaxis and therapy of cerebral ischemia
    1.
    发明专利
    Use of pyrimidine derivatives for the prophylaxis and therapy of cerebral ischemia 未知

    公开(公告)号：NZ512767A

    公开(公告)日：2003-05-30

    申请号：NZ51276799

    申请日：1999-12-24

    Applicant: BASF AG

    Inventor： SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO JAVIER ,  HOFMANN HANS-PETER ,  UNGER LILIANE ,  STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  KNOPP MONIKA

    IPC: C07D495/04 ,  A61K31/505 ,  A61K31/519 ,  A61P9/10 ,  C07D495/14 ,  A61K31/513 ,  A61K31/55

    Abstract: The use of pyrimidine derivatives of the formula (I) where: A is NH or oxygen; B is hydrogen or methyl; D is methyl; E is ¥ C ¥ Nr3R4 or Q% O D and E are together ûCH2-CH2-NR1-CH2-, -CH2-NR1-CH2- or -CH2-NR1-CH2-CH2-; X is nitrogen; Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH; Z is nitrogen, carbon or CH, with it also being possible for the bond between Y and Z to be a double bond, N is the number 2, 3 or 4; R1 is hydrogen, a C1-C4-alkyl group, and acetyl or benzoyl group, a phenylalkyl C1-C4-alkyl group, an acetyl or benzoyl group, a phenylalkyl C1-C4 radical, with the aromatic moiety optionally being substituted by halogen, or C1-C4-alkyl, trifluoromethyl, hydroxy, C1-C4-alkoxy, amino, cyano or nitro groups, a napthylalkyl C1-C3 radical, a phenylalkanone C2-C3 radical or a phenylcarbamoylalkyl C2 radical, with it being possible for the phenyl group to be substituted by halogen; R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is optional monosubstituted, disubstituted or trisubstituted by halogen atoms, C1-C4-alkyl or be substituted by halogen, a C1-C4-alkyl group, a methoxy group and by a nitro or amino group; R2 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is optionally monosubstituted, disubstituted or trisubstituted by halogen atoms, C1-C4-alkyl or trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which can optionally be fused to a benzene nucleus which can optionally be monosubstituted or disubstituted by halogen atoms, C1-C4-alkyl or hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and which can optionally contain 1 nitrogen atom, or to a 5- or 6-membered ring which can contain 1-2 oxygen atoms, or can be substituted by a phenyl-C1-C2-alkyl- or ûalkoxy group, with it being possible for the phenyl radical to be substituted by halogen, or a methyl, trifluoromethyl or methoxy group; R3 and R4 are, independently of each other, hydrogen or a C1-C4-alkyl group, and of their physiologically tolerated salts for producing medicaments for the prophylaxis and treatment of cerebral ischemia and strokes.

Patent Agency Ranking