公开(公告)号：WO1997014174A1

公开(公告)日：1997-04-17

申请号：PCT/US1996016250

申请日：1996-10-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  CHUTJIAN, Ara ,  HECHT, Michael, H. ,  ORIENT, Otto, J.

IPC: H01J49/42

CPC classification number: H01J49/4215 ,  H01J49/0013 ,  H01J49/009

Abstract: The present invention provides a miniature quadrupole mass spectrometer array (100) for the separation of ions, comprising a first pair of parallel, planar, nonmagnetic conducting rods (130) each having an axis of symmetry, a second pair of planar, nonmagnetic conducting rods (130) each having an axis of symmetry parrallel to said first pair of rods and disposed such that a line perpendicular to each of said first axes of symmetry and a line perpendicular to each of said second axes of symmetry bisect each other and form a generally 90 degree angle. A nonconductive top positioning plate (120) is positioned generally perpendicular to the first and second pairs of rods (130) and has an aperture for ion entrance (205) along an axis equidistant from each axis of each of the parallel rods (130), a nonconductive bottom positioning plate (145) is generally parallel to the top positioning plate (120) and has an aperture for ion exit (162) centered on an axis equidistant from each axis of symmetry of each of the parallel rods (162), means for maintaining a direct current voltage between the first and second pairs of rods, and means for applying a radio frequency voltage to the first and second pairs of rods.

Abstract translation: 本发明提供了一种用于分离离子的微型四极杆质谱仪阵列（100），包括分别具有对称轴线的第一对平行，非磁性导电棒（130），第二对平面非磁性导电棒 （130），每个具有与所述第一对杆对称的对称轴线，并且设置成使得垂直于每个所述第一对称轴线的线和垂直于每个所述第二对称轴线的线互相平分并形成一般 90度角。 非导电顶部定位板（120）大致垂直于第一和第二对杆（130）定位，并且具有沿着与每个平行杆（130）的每个轴线等距的轴的离子入口（205）的孔， 非导电底部定位板（145）通常平行于顶部定位板（120）并且具有以每个平行杆（162）的每个对称轴线等距的轴为中心的离子出口孔（162），装置 用于在第一和第二对杆之间保持直流电压;以及用于将射频电压施加到第一和第二对杆的装置。

公开(公告)号：WO1997005489A1

公开(公告)日：1997-02-13

申请号：PCT/US1996010065

申请日：1996-06-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  ARNOLD, Frances, H. ,  GUAN, Zhibin ,  CHEN, Chao-Tsen

IPC: G01N33/66

CPC classification number: C12Q1/006 ,  G01N33/66 ,  G01N2600/00 ,  G01N2650/00

Abstract: A sensor for use in detecting the presence of sugars and related molecules in aqueous solutions. The sensor is composed of a metal complex that binds to the targeted sugar or other molecule in aqueous solution with the result being the release of a proton. Measurement of proton release from the sensor provides an indirect indication of target molecule concentration. The metal complexes may be attached to support structures to provide both anchoring and positioning of the metal ions to increase selectivity of sugar/metal complex interactions. Detection systems in which pH is used as an indication of proton release are disclosed. Methods for monitoring the concentrations of sugars and related molecules using the metal complex sensors are also disclosed.

Abstract translation: 用于检测水溶液中糖和相关分子的存在的传感器。 该传感器由在水溶液中与目标糖或其他分子结合的金属络合物组成，结果是质子的释放。 传感器质子释放的测量提供了目标分子浓度的间接指示。 金属络合物可以连接到支撑结构，以提供金属离子的锚定和定位，以增加糖/金属络合物相互作用的选择性。 公开了使用pH作为质子释放指示的检测系统。 还公开了使用金属络合物传感器监测糖和相关分子的浓度的方法。

公开(公告)号：WO1995015971A3

公开(公告)日：1995-06-15

申请号：PCT/US1994013893

申请日：1994-12-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  MEADE, Thomas, J. ,  KAYYEM, Jon, F. ,  FRASER, Scott, E.

IPC: C07H21/00

公开(公告)号：WO1994023078A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003850

申请日：1994-04-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  PEKER, Atakan ,  JOHNSON, William, L.

IPC: C22C09/00

CPC classification number: C22C45/10

Abstract: Alloys which form metallic glass upon cooling below the glass transition temperature at a rate appreciably less than 10 K/s comprise beryllium in the range of from 2 to 47 atomic percent and at least one early transition metal in the range of from 30 to 75 % and at least one late transition metal in the range of from 5 to 62 %. A preferred group of metallic glass alloys has the formula: (Zr1-xTix)a(Cu1-yNiy)bBec. Generally, a is in the range from 30 to 75 % and the lower limit increases with increasing x. When x is in the range of from 0 to 0.15, b is in the range of from 5 to 62 %, and c is in the range of from 6 to 47 %. The value of c lies between 2 to 47 % depending on correlated value ranges for x and b within the broad range 0

Abstract translation: 在低于玻璃化转变温度的玻璃化转变温度下以大大低于10 6 K / s的速率冷却时形成金属玻璃的合金包括2至47原子百分比的铍和至少一种在30 至75％，至少一种后过渡金属在5至62％的范围内。 优选的一组金属玻璃合金具有下式：（Zr1-xTix）a（Cu1-yNiy）bBec。 一般情况下，a在30〜75％范围内，下限随着x的增加而增加。 当x在0至0.15的范围内时，b在5至62％的范围内，c在6至47％的范围内。 取决于在宽范围0

公开(公告)号：WO1994008185A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009131

申请日：1993-09-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  JONES, Jack, A. ,  YAVROUIAN, Andre, H.

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY

IPC: F25B17/08

CPC classification number: F25B35/04 ,  Y02A30/278 ,  Y02B30/64 ,  Y10T29/4935 ,  Y10T29/49378

Abstract: An integral adsorbent-heat exchanger device is provided which is useful in ammonia refrigerant heat pump system. The integral apparatus (10) comprises a tube (13) with fins (11) having the activated carbon (14) filled in the spaces between the fins (11).

Abstract translation: 提供了一种整体式的吸附 - 热交换器装置，可用于氨制冷剂热泵系统。 整体装置（10）包括具有翅片（11）的管（13），其具有填充在翅片（11）之间的空间中的活性炭（14）。

公开(公告)号：WO1993018187A1

公开(公告)日：1993-09-16

申请号：PCT/US1993002352

申请日：1993-03-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  DERVAN, Peter, B.

IPC: C12Q01/68

CPC classification number: C07H21/00 ,  C07H19/16 ,  C12Q1/6839

Abstract: Oligonucleotides and processes for their use for specific recognition of a target sequence in double-stranded nucleix acid through the formation of a triple helix. The oligonucleotides contain nebularine and bind to one of the strands of the target sequence. The oligonucleotides can be used as diagnostic or therapeutic agents through incorporation of an appropriate moiety in one or more nucleotides in the triple helix forming oligonucleotide.

Abstract translation: 寡核苷酸及其用于通过形成三重螺旋特异性识别双链核酸中靶序列的方法。 寡核苷酸含有微球，并与靶序列的一条链结合。 寡核苷酸可以通过在三螺旋形成寡核苷酸中的一个或多个核苷酸中掺入适当的部分来用作诊断或治疗剂。

公开(公告)号：WO1989000029A1

公开(公告)日：1989-01-12

申请号：PCT/US1988002196

申请日：1988-06-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  COOTS, Robert, J. ,  PINE, Stanley, H. ,  GRUBBS, Robert, H.

IPC: A61B19/00

CPC classification number: A61F2/14 ,  A61F2/16 ,  A61F2/1624 ,  A61F2/1662 ,  A61L27/14

Abstract: A synthetic polymer (24) is provided for endocapsular lens (18) replacement in an eye (10). The polymer, which is injected into the lens capsule (16) after removal of the lens, comprises an oxygen-stabilized photosensitive prepolymer. An example of such a prepolymer comprises polyether with urethane linkages with one or both ends capped with a functional group containing at least one double bond, such as an acrylate, a methacrylate, or a styrene. The polymerization reaction is initiated with a photoinitiator such as dimethoxyphenylacetophenone and is quenched in the presence of oxygen. Contrary to the prior art polymers, the time of curing is on the order of only a minute or so. The viscosity and thickness of the polymer formed may be tailored to achieve a desired index of refraction of between about 1.3 and 1.6.

Abstract translation: 提供合成聚合物（24）用于眼睛（10）中的囊内透镜（18）置换。 去除透镜后注入透镜胶囊（16）中的聚合物包含氧稳定的光敏预聚物。 这种预聚物的实例包括具有聚氨酯键的聚醚，其一端或两端用包含至少一个双键的官能团如丙烯酸酯，甲基丙烯酸酯或苯乙烯封端。 聚合反应用光引发剂例如二甲氧基苯乙酰苯引发，并在氧的存在下淬灭。 与现有技术的聚合物相反，固化时间只有一分钟左右。 形成的聚合物的粘度和厚度可以被定制以达到在约1.3和1.6之间的所需折射率。

公开(公告)号：WO1998020376A1

公开(公告)日：1998-05-14

申请号：PCT/US1997020405

申请日：1997-11-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  VAHALA, Kerry, John ,  PAIELLA, Roberto ,  HUNZIKER, Guido

IPC: G02B06/00

CPC classification number: G02F1/3515 ,  G02F2/004 ,  G02F3/00 ,  G02F2203/70

Abstract: All-optical logic gates in which binary words are encoded using wavelength. A method and apparatus for processing information in this wavelength encoded format is provided. The processing may occur entirely in the optical domain. This approach is modular and enables construction of logic gates using custom waveguide chips that can be mass-produced in a manner similar to that of conventional electronic digital chips. Specific gates, such as AND, OR, EXOR, or NAND, may be "programmed" into a given chip during its fabrication to encode the desired truth table. The ouptut states of the chip are determined by ultrafast mixing of binary encoded wavelengths in a semiconductor optical amplifier. The result is a new wavelength having a relationship to the input wavelengths determined entirely by the desired truth table.

Abstract translation: 使用波长对二进制字进行编码的全光逻辑门。 提供了一种用于处理该波长编码格式的信息的方法和装置。 该处理可以完全在光学域中发生。 该方法是模块化的，并且可以使用可以以类似于常规电子数字芯片的方式批量生产的定制波导芯片来构建逻辑门。 诸如AND，OR，EXOR或NAND的特定门可以在其制造期间被编程到给定芯片中以对期望的真值表进行编码。 通过在半导体光放大器中的二进制编码波长的超快速混合来确定芯片的断开状态。 结果是与完全由所需真值表确定的输入波长具有关系的新波长。

公开(公告)号：WO1998013491A2

公开(公告)日：1998-04-02

申请号：PCT/US1997017048

申请日：1997-09-24

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  ANDERSON, David, J. ,  MA, Qiufu ,  SOMMER, Lukas

IPC: C12N15/12

CPC classification number: C07K14/475 ,  Y10S530/839 ,  Y10S530/855

Abstract: The invention relates to novel neurogenin proteins, nucleic acids and antibodies.

Abstract translation: 本发明涉及新型神经元蛋白，核酸和抗体。

公开(公告)号：WO1998012580A1

公开(公告)日：1998-03-26

申请号：PCT/US1997016644

申请日：1997-09-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CALIFORNIA INSTITUTE OF TECHNOLOGY ,  HOENCK, Michael, E.

IPC: G01W01/00

CPC classification number: G01N25/68

Abstract: Dewpoint/frostpoint hygrometer (1) using surface moisture-sensitive sensor as part of an RF oscillator circuit with feedback control of the sensor temperature to maintain equilibrium at sensor surface between ambient water vapor and condensed water/ice. The invention is preferably implemented using a surface acoustic wave (SAW) device (32) and RF oscillator (36) in RF oscillator circuit (35) configured to generate a condensation-dependent output signal, a temperature sensor (60) to measure temperature of the SAW device and distinguish between condensation-dependent and temperature-dependent signals, a temperature regulating device such as thermoelectric cooler (30) that controls temperature of the SAW device, and a feedback control system (5) with voltage-sensing circuit (64) and current amplifier (22) configured to keep condensation-dependent signal nearly constant over time in the presence of time-varying humidity, as corrected for temperature. This response effects to heat or cool the surface moisture-sensitive device, thereby shifting equilibrium with respect to evaporation and condensation on surface of device. The equilibrium temperature under feedback control is a measure of dewpoint or frostpoint.

Abstract translation: 露点/霜冻湿度计（1）使用表面湿度敏感传感器作为RF振荡器电路的一部分，具有传感器温度的反馈控制，以保持环境水蒸气和冷凝水/冰之间传感器表面的平衡。 本发明优选使用在RF振荡器电路（35）中的表面声波（SAW）器件（32）和RF振荡器（36）来实现，该RF振荡器电路（35）被配置为产生与冷凝相关的输出信号，温度传感器（60） 所述SAW器件区分冷凝依赖和依赖于温度的信号，温度调节装置，例如控制SAW器件的温度的热电冷却器（30）和具有电压检测电路（64）的反馈控制系统（5） 以及电流放大器（22），其被配置为在随时间变化的湿度存在的情况下随着时间的推移使冷凝相关信号几乎恒定，如针对温度校正的。 该响应对加热或冷却表面湿度敏感装置产生影响，从而相对于装置表面上的蒸发和冷凝移动平衡。 反馈控制下的平衡温度是露点或霜点的度量。