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    MICROMOTORS WITH UTILITARIAN FEATURES AND METHODS OF THEIR FABRICATION
    32.
    发明申请
    MICROMOTORS WITH UTILITARIAN FEATURES AND METHODS OF THEIR FABRICATION 审中-公开
    具有UTILITARIAN特征的微型电机及其制造方法

    公开(公告)号：WO1995034943A1

    公开(公告)日：1995-12-21

    申请号：PCT/US1994014799

    申请日：1994-12-22

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  MEHREGANY, Mehran ,  MERAT, Francis, L.

    IPC: H02N01/00

    CPC classification number: F04D13/06 ,  G02B26/0816 ,  G02B26/106 ,  G02B26/121 ,  H02N1/004

    Abstract: Micromotors are fabricated with utilitarian features (21) on their rotors (23). In some embodiments, the features are formed by the molded addition of material on top of a rotor surface. In other embodiments, the features are formed by the provision of an additional layer on top of the rotor, and the selective removal of material therefrom. In yet other embodiments, the features are defined by the selective removal of material from the rotor itself. The disclosure is particularly illustrated with reference to the fabrication of polygon (nickel) mirror (21) on a polysilicon, electrostatic micromotor rotor (23) for use in scanning applications. However, the principles of the invention can likewise be applied to fabrication of a variety of other features, such as optical gratings, shutters, mechanical actuators, pump impellers and fins, and to a variety of different micrometer constructions.

    Abstract translation: 微电机在其转子（23）上用功利特征（21）制造。 在一些实施例中，通过在转子表面的顶部上模制添加材料形成特征。 在其它实施例中，特征是通过在转子顶部设置附加层以及从中选择性地移除材料形成的。 在其它实施例中，通过从转子本身选择性地去除材料来限定特征。 具体地参考在用于扫描应用的多晶硅，静电微电机转子（23）上制造多边形（镍）反射镜（21）而进行的公开。 然而，本发明的原理同样可以应用于各种其他特征的制造，例如光栅，百叶窗，机械致动器，泵叶轮和翅片，以及各种不同的千分尺结构。

    BIOMATRIX FOR TISSUE REGENERATION
    33.
    发明申请
    BIOMATRIX FOR TISSUE REGENERATION 审中-公开
    生物组织用于组织再生

    公开(公告)号：WO1995033421A1

    公开(公告)日：1995-12-14

    申请号：PCT/US1995007066

    申请日：1995-06-05

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY

    IPC: A61F02/02

    CPC classification number: A61L27/3834 ,  A61B17/06066 ,  A61B17/06166 ,  A61B17/1146 ,  A61B2017/00004 ,  A61F2/08 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/3099 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61L17/06

    Abstract: This invention is an implant (1) for repair of a tissue defect which implant (1) comprises a strand or suture material (2) and a gel matrix (4) containing reparative cells (6) which has been contracted around central portion (8) of suture (2). Suture (2) has free ends (10 and 12) which are used to rejoin the tissue adjacent the defect. Free ends (10 and 12) can be sewn into the body of the tissue thereby holding the ends of the tendon in place and also holding gel matrix (4) in position in the defect.

    Abstract translation: 本发明是用于修复组织缺损的植入物（1），所述植入物（1）包括股线或缝线材料（2）和含有修复细胞（6）的凝胶基质（4），所述修复细胞已经在中心部分 ）缝合线（2）。 缝合线（2）具有用于重新连接缺损附近的组织的自由端（10和12）。 可以将自由端（10和12）缝合到组织的主体中，从而将腱的端部保持在适当位置，并且还将凝胶基质（4）保持在缺陷中的适当位置。

    GROWTH ARREST HOMEOBOX GENE
    34.
    发明申请
    GROWTH ARREST HOMEOBOX GENE 审中-公开
    生长寄主家禽基因

    公开(公告)号：WO1995023161A1

    公开(公告)日：1995-08-31

    申请号：PCT/US1995001882

    申请日：1995-02-22

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  GORSKI, David, H. ,  WALSH, Kenneth

    IPC: C07H21/00

    CPC classification number: C07K14/4703 ,  A61K38/00

    Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the "Gax gene" and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

    Abstract translation: 已经发现了一种新的生长停滞同源盒基因，并且已经在大鼠和人中确定了核苷酸序列。 新型同源盒基因的表达抑制血管平滑肌细胞生长。 生长停滞同源盒基因以下简称为“Gax基因”及其相应的蛋白质可用于血管平滑肌细胞增殖的研究，以及由过度平滑肌细胞增殖引起的血管疾病的治疗，特别是球囊血管成形术 。

    EPISOMAL EXPRESSION VECTOR FOR HUMAN GENE THERAPY
    35.
    发明申请
    EPISOMAL EXPRESSION VECTOR FOR HUMAN GENE THERAPY 审中-公开
    人类基因治疗的表现表达载体

    公开(公告)号：WO1995013377A1

    公开(公告)日：1995-05-18

    申请号：PCT/US1994004049

    申请日：1994-04-13

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  COOPER, Mark, J.

    IPC: C12N15/37

    CPC classification number: C07K14/005 ,  A61K48/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2710/22022 ,  C12N2800/108

    Abstract: Episomal plasmids containing a papovavirus origin of replication and a papovavirus large T antigen mutant form are shown to replicate episomally in human cells, and yield levels of gene expression proportional to their episomal copy number. In conjunction with liposomal or receptor-mediated delivery systems, papovavirus-derived episomal plasmids provide an alternative vector for gene therapy, particularly when utilizing strategies requiring high levels of gene expression.

    Abstract translation: 显示含有乳头瘤病毒复制起点和乳头瘤病毒大T抗原突变体形式的上皮质粒在人细胞中附加复制，并且产生与其附加型拷贝数成正比的基因表达水平。 结合脂质体或受体介导的递送系统，来自乳头瘤病毒的附加型质粒提供用于基因治疗的替代载体，特别是当使用需要高水平基因表达的策略时。

    VENTILATOR PROSTHESIS
    36.
    发明申请
    VENTILATOR PROSTHESIS 审中-公开
    通风机前置

    公开(公告)号：WO1995003004A1

    公开(公告)日：1995-02-02

    申请号：PCT/US1994008386

    申请日：1994-07-22

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  SCHMIT, Brian, D. ,  MORTIMER, J., Thomas

    IPC: A61B19/00

    CPC classification number: A61N1/3601 ,  A61N1/0551

    Abstract: A laparoscopic vacuum delivery device (100) is used for placing an epimysial electrode (96) at the phrenic nerve motor point. The vacuum delivery device is adapted to hold the epimysial electrode while the electrode is introduced through a port into the abdomen during a laparoscopic procedure. The electrode is forcibly held against the diaphragm muscle surface (118) for test stimulation using a suction port (112) through the delivery device. Multiple test sites may be explored by controlling the suction to and the position of the delivery device. The electrode is secured at an optimal location on the diaphragm muscle using an endoscopic stapler.

    Abstract translation: 腹腔镜真空输送装置（100）用于在膈神经运动点放置epimysial电极（96）。 真空输送装置适于在腹腔镜手术期间将电极通过端口引入腹部来保持表皮电极。 电极被强制地保持抵靠隔膜肌肉表面（118），以便通过输送装置使用吸入口（112）进行刺激。 可以通过控制输送装置的吸力和位置来探索多个测试部位。 使用内窥镜吻合器将电极固定在隔膜肌肉的最佳位置。

    COMPOSITE FIBERS HAVING A DIAMOND SURFACE
    38.
    发明申请
    COMPOSITE FIBERS HAVING A DIAMOND SURFACE 审中-公开
    具有金刚石表面的复合纤维

    公开(公告)号：WO1994006599A1

    公开(公告)日：1994-03-31

    申请号：PCT/US1993009043

    申请日：1993-09-23

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  GAT, Roy

    IPC: B24D11/00

    CPC classification number: B24D11/00 ,  Y10T428/2927 ,  Y10T428/2933 ,  Y10T428/294

    Abstract: The present invention relates to composite fibers having a diamond surface which can be produced using a substrate such as graphite, or other non-diamond inorganic fiber. These substrates produced in the manner described, give rise to improved diamond deposits producing composite fibers having properties not heretofore available.

    Abstract translation: 本发明涉及具有金刚石表面的复合纤维，其可以使用诸如石墨的基底或其它非金刚石无机纤维来制造。 以所述方式生产的这些基材产生改善的金刚石沉积物，其生产具有以前不具备的性能的复合纤维。

    THIN FILM IMPLANTABLE ELECTRODE AND METHOD OF MANUFACTURE
    39.
    发明申请
    THIN FILM IMPLANTABLE ELECTRODE AND METHOD OF MANUFACTURE 审中-公开
    薄膜可植入电极及其制造方法

    公开(公告)号：WO1993020887A1

    公开(公告)日：1993-10-28

    申请号：PCT/US1993003720

    申请日：1993-04-20

    Applicant: CASE WESTERN RESERVE UNIVERSITY

    Inventor： CASE WESTERN RESERVE UNIVERSITY ,  GRILL, Warren, M., Jr. ,  CREASEY, Graham, H. ,  KSIENSKI, David, A. ,  VERAART, Claude, G. ,  MORTIMER, J., Thomas

    IPC: A61N01/04

    CPC classification number: A61N1/05 ,  A61N1/0556

    Abstract: A sheet (30) of polymeric material defines a cuff portion (A), a contact portion (B), and an interconnecting elongated lead portion (C). Using physical vapor deposition (PVD), chemical vapor deposition (CVD), or other thin film deposition techniques, a plurality of electrodes (12), contact pads (16), and interconnecting leads (14) are deposited on the base layer. An elastomer covering layer (18) is laminated to the base layer. The elastomeric covering layer is stretched along direction (24) before lamination, such that at least the cuff portion is elastomerically biased to curl into a spiral. Windows (20) are defined in the elastomeric portion to provide for electrical conduction between the electrodes (12) and nerve tissue about which the cuff electrode is wrapped. The electrodes are arced (Figure 6) such that they are more recessed adjacent sides of the window than adjacent the center in order to provide a substantially uniform flux density across the electrode surface.

    Abstract translation: 聚合物材料的片材（30）限定了袖带部分（A），接触部分（B）和互连的细长引线部分（C）。 使用物理气相沉积（PVD），化学气相沉积（CVD）或其它薄膜沉积技术，多个电极（12），接触焊盘（16）和互连引线（14）沉积在基层上。 弹性体覆盖层（18）层压到基层。 弹性体覆盖层在层压之前沿着方向（24）被拉伸，使得至少袖带部分被弹性偏置以卷曲成螺旋。 窗口20限定在弹性体部分中以提供电极（12）和袖带电极所围绕的神经组织之间的导电。 电极（图6）使得它们比邻近中心更靠近窗口凹陷，以便在电极表面上提供基本均匀的通量密度。

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