公开(公告)号：WO1993015599A1

公开(公告)日：1993-08-19

申请号：PCT/US1993000869

申请日：1993-01-29

Applicant: CORNELL RESEARCH FOUNDATION, INC.

Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  STEFFENS, John, C.

IPC: A01H05/00

CPC classification number: C12Y110/03001 ,  C12N9/0059 ,  C12N9/0071 ,  C12N15/8241 ,  C12Y114/18001

Abstract: The present invention describes the cloning and sequencing of plant Polyphenol Oxidase (PPO) cDNAs which has subsequently permitted their use to genetically transform plants to achieve a variety of desired phenotypes.

Abstract translation: 本发明描述了植物多酚氧化酶（PPO）cDNA的克隆和测序，其随后允许其用于遗传转化植物以实现各种期望的表型。

公开(公告)号：WO1993002551A1

公开(公告)日：1993-02-18

申请号：PCT/US1992006492

申请日：1992-08-04

Applicant: KARASH, Michael, J. ,  KEREM, Elitan ,  CORNELL RESEARCH FOUNDATION, INC. ,  GVARYAHU, Gadi

Inventor： KARASH, Michael, J. ,  KEREM, Elitan ,  CORNELL RESEARCH FOUNDATION, INC.

IPC: A01K29/00

CPC classification number: A01K15/025

Abstract: A farm animal toy (10) including a colored structure (12, 18) suitable for stimulating at least one farm animal characterized in that the color of the colored structure is selected so as to significantly improve at least one measure of the output of at least one farm animal.

Abstract translation: 一种农场动物玩具（10），包括适于刺激至少一个农场动物的有色结构（12,18），其特征在于，选择着色结构的颜色，以便显着改善至少一个至少一个产量的量度 一个农场动物。

公开(公告)号：WO1992016581A1

公开(公告)日：1992-10-01

申请号：PCT/US1992001878

申请日：1992-03-10

Applicant: CORNELL RESEARCH FOUNDATION, INC.

Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  FRECHET, Jean ,  SVEC, Frantisek ,  HOSOYA, Ken

IPC: C08J09/26

CPC classification number: C08J9/26 ,  C08F291/00 ,  C08F2/18

Abstract: A process for producing macroporous polymer beads from a multiphase emulsion using soluble polymer particles as the primary porogen is disclosed. The beads produced are of uniform size and shape.

公开(公告)号：WO1992008749A1

公开(公告)日：1992-05-29

申请号：PCT/US1991007975

申请日：1991-10-28

Applicant: CORNELL RESEARCH FOUNDATION, INC.

Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  FRECHET, Jean, M., J. ,  HAWKER, Craig, J. ,  UHRICH, Kathryn

IPC: C08G63/06

CPC classification number: C08G83/005 ,  C08G63/065 ,  C08G63/20 ,  C08G69/08 ,  C08G69/48

Abstract: Hyperbranched polyester and polyamide polymers are prepared by a one-step process of polymerizing a monomer of the formula A-R-B2 so that high molecular weight globular polymers having a multiplicity of a particular functional group on the outside surface are obtained.

Abstract translation: 通过聚合式A-R-B2的单体的一步法制备超支化聚酯和聚酰胺聚合物，从而获得在外表面上具有多个特定官能团的高分子量球状聚合物。

公开(公告)号：WO1989004316A1

公开(公告)日：1989-05-18

申请号：PCT/US1988003716

申请日：1988-10-26

Applicant: CORNELL RESEARCH FOUNDATION, INC.

Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  THEOPOLD, Klaus, H. ,  BYRNE, Erin, K.

IPC: C07F09/70

CPC classification number: C22C1/007 ,  C07F9/70

Abstract: A novel gallium arsenide precursor has the formula R2GaAs(SiR')2 wherein R is selected from the group consisting of alkyl substituted cycloaliphatic group and alkyl substituted aromatic group and R' is alkyl. Preferably, R is pentamethylclopentadienyl and R' is methyl. The precursor is reacted with an alcohol, preferably ethanol or t-butanol at a temperature ranging from -20 DEG C. to 60 DEG C., preferably at room temperature, under water free conditions to form solid gallium arsenide and by-products which are liquid under the reaction conditions.

公开(公告)号：WO1998025945A1

公开(公告)日：1998-06-18

申请号：PCT/US1997022851

申请日：1997-12-04

Applicant: CORNELL RESEARCH FOUNDATION, INC.

Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  YE, Gui-jie ,  BRESLOW, Esther ,  MEISTER, Alton +di

IPC: C07H21/02

CPC classification number: C12N9/86

Abstract: The present invention is directed to isolated nucleic acid molecules encoding mammalian 5-oxoprolinase (m 5-OPase). Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the expression of m 5-OPase in host cells. The invention further provides a method of screening a substance for the ability of the substance to modify m 5-OPase function, and a method for isolating other m 5-OPase molecules. DNA oligomers and antibodies specific for m 5-OPase are provided, each of which can be used to detect m 5-OPase in a sample.

Abstract translation: 本发明涉及编码哺乳动物5-氧代罗维拉酸酶（m 5-OPase）的分离的核酸分子。 还提供了包含核酸分子的表达载体和宿主细胞，以及用于增加或降低宿主细胞中m 5 -OPase表达的方法。 本发明还提供了筛选物质以修饰m 5-OPase功能的能力的方法，以及分离其它m 5-OPase分子的方法。 提供DNA寡聚体和针对m 5-OPase特异性的抗体，其中每一种可用于检测样品中的5-OPase。

公开(公告)号：WO1998010072A1

公开(公告)日：1998-03-12

申请号：PCT/US1997015891

申请日：1997-09-08

Applicant: CORNELL RESEARCH FOUNDATION, INC.

Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  JOH, Tong, H. ,  CONTI, Bruno

IPC: C12N15/24

CPC classification number: C07K14/54

Abstract: The present invention relates to isolated DNA molecules encoding interferon- gamma inducing factors, interleukin-18 and interleukin-18 alpha , from rat. The invention also provides the rat interferon- gamma inducing factor proteins or polypeptides identified as interleukin-18 and interleukin-18 alpha . The use of these materials is also disclosed.

Abstract translation: 本发明涉及编码来自大鼠的干扰素-γ诱导因子，白细胞介素-18和白细胞介素-18α的分离的DNA分子。 本发明还提供了大鼠干扰素-γ诱导因子蛋白或被鉴定为白细胞介素-18和白细胞介素-18α的多肽。 还公开了这些材料的使用。

公开(公告)号：WO1997049827A2

公开(公告)日：1997-12-31

申请号：PCT/US1997011229

申请日：1997-06-26

Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  CRYSTAL, Ronald, G. ,  MAGOVERN, Christopher, J. ,  ROSENGART, Todd ,  HOFFMAN, Lloyd ,  TALMOR, Mia

Inventor： CORNELL RESEARCH FOUNDATION, INC.

IPC: C12N15/86

CPC classification number: C12N15/86 ,  A61F2/02 ,  A61K35/12 ,  A61K48/00 ,  C07K14/52 ,  C12N5/0653 ,  C12N2710/10343 ,  C12N2830/008

Abstract: The present invention provides gene transfer to adipocytes mediated by adenovirus and, in particular, transfer of toxic genes as a means of reducing adiposity and transfer of genes encoding angiogenic substances to induce new blood vessel growth, as well as adipose tissue implants.

Abstract translation: 本发明提供了由腺病毒介导的脂肪细胞的基因转移，特别是毒性基因的转移，作为减少肥胖和转移编码血管生成物质的基因以诱导新血管生长的手段以及脂肪组织植入物。

公开(公告)号：WO1997031622A1

公开(公告)日：1997-09-04

申请号：PCT/US1997003306

申请日：1997-02-26

Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  SMITH, Kendall, A.

Inventor： CORNELL RESEARCH FOUNDATION, INC.

IPC: A61K09/06

CPC classification number: A61K38/2013 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/887

Abstract: A method of activating the immune system of a subject comprises the chronic administration of low doses of an agent such as IL-2, fusion proteins thereof and derivatives thereof that are pharmaceutically acceptable. The agent is provided as a dermal composition, transdermal delivery device and electrotransport device as well as in the form of a kit for self-administration.

Abstract translation: 激活受试者的免疫系统的方法包括慢性施用低剂量的药物如IL-2，其融合蛋白及其衍生物，其为药学上可接受的。 该试剂作为皮肤组合物，透皮递送装置和电转运装置以及用于自我给药的试剂盒的形式提供。

公开(公告)号：WO1997031256A2

公开(公告)日：1997-08-28

申请号：PCT/US1997001535

申请日：1997-02-05

Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  UNIVERSITY OF MINNESOTA ,  LOUISIANA STATE UNIVERSITY ,  BARANY, Francis ,  BARANY, George ,  HAMMER, Robert, P. ,  KEMPE, Maria ,  BLOK, Herman ,  ZIRVI, Monib

Inventor： CORNELL RESEARCH FOUNDATION, INC. ,  UNIVERSITY OF MINNESOTA ,  LOUISIANA STATE UNIVERSITY

IPC: G01N00/00

CPC classification number: B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00729 ,  B82Y30/00 ,  C07B2200/11 ,  C12Q1/6837 ,  C12Q1/689 ,  C40B20/02 ,  C40B50/14 ,  Y02A50/58 ,  C12Q2565/513 ,  C12Q2561/125

Abstract: The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves.

Abstract translation: 本发明描述了用于鉴定多个靶核苷酸序列中一个或多个单碱基变化，插入，缺失或易位不同的多个序列中的一个或多个的方法。 该方法包括连接阶段，捕获阶段和检测阶段。 连接阶段利用具有目标序列特异性部分的一个寡核苷酸探针与可寻址阵列特异性部分之间的连接检测反应和具有靶序列特异性部分和可检测标记的第二寡核苷酸探针。 在连接阶段之后，捕获阶段通过将连接的寡核苷酸探针与具有固定化捕获寡核苷酸阵列的固体支持物杂交进行，其中至少一些与可寻址阵列特异性部分互补。 捕获阶段完成后，进行检测阶段以检测与固体支持物杂交的连接的寡核苷酸探针的标记。 连接阶段之前可以进行扩增过程。 本发明还涉及一种用于实施该方法的试剂盒，在固体支持物上形成阵列的方法和载体本身。