公开(公告)号：WO2007103721A3

公开(公告)日：2007-11-08

申请号：PCT/US2007063058

申请日：2007-03-01

Applicant: GEN HOSPITAL CORP ,  NADKARNI SEEMANTINI K ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  VAKOC BENJAMIN J ,  ANDERSON RICHARD ROX

Inventor： NADKARNI SEEMANTINI K ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  VAKOC BENJAMIN J ,  ANDERSON RICHARD ROX

IPC: A61N5/06

CPC classification number: A61B18/245 ,  A61N5/0601 ,  A61N5/062

Abstract: An apparatus and method according to the present invention can be provided, e.g., for a cell specific laser therapy of atherosclerotic plaques, particularly to systems and methods for targeting endogenous light absorbers present within plaque macrophages and exogenous nanoparticle targeting. In one exemplary embodiment, an electro-magnetic radiation can be forwarded to an anatomical structure. The electro-magnetic radiation may have at least one property configured to (a) modify at least one characteristic of at least one first cell, and (b) minimize any modification of and/or modify at least one characteristic of at least second cell. The first and second cells may be different from one another, the characteristics of the first and second cells can be different from one another, and the first cell and/or the second cell may have at least one macrophage feature, and the characteristic of the at least one first cell and/or the at least one second cell can be temperature. According to still another exemplary embodiment, a location associated with the first cell and the second cell can be determined. For example, the electro-magnetic radiation can be forwarded in a vicinity of the location.

Abstract translation: 可以提供根据本发明的设备和方法，例如用于动脉粥样硬化斑块的细胞特异性激光治疗，特别是用于靶向存在于斑块巨噬细胞内的内源光吸收剂和外源纳米颗粒靶向的系统和方法。 在一个示例性实施例中，电磁辐射可被转发至解剖结构。 电磁辐射可以具有至少一种性质，其被配置为（a）修改至少一个第一电池的至少一个特性，并且（b）最小化至少第二电池的任何修改和/或修改至少一个特性。 第一和第二细胞可以彼此不同，第一和第二细胞的特征可以彼此不同，并且第一细胞和/或第二细胞可以具有至少一个巨噬细胞特征，并且第一和第二细胞的特征 至少一个第一电池和/或至少一个第二电池可以是温度。 根据又一示例性实施例，可以确定与第一小区和第二小区相关联的位置。 例如，可以在该位置附近发送电磁辐射。

公开(公告)号：WO03046636A9

公开(公告)日：2004-02-26

申请号：PCT/US0238335

申请日：2002-11-27

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  WEBB ROBERT H ,  PITRIS CONSTANTINOS ,  SHISHKOV MILLEN

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  WEBB ROBERT H ,  PITRIS CONSTANTINOS ,  SHISHKOV MILLEN

IPC: A61B1/00 ,  A61B1/07 ,  A61B5/00 ,  A61B10/00 ,  A61B19/00 ,  G01J3/28 ,  G02B21/00 ,  G02B21/18 ,  G02B21/36 ,  G02B23/24 ,  G02B21/06

CPC classification number: A61B1/00096 ,  A61B1/00172 ,  A61B5/0068 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6852 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0291 ,  G01J3/06 ,  G01J3/12 ,  G01J3/14 ,  G01J3/18 ,  G01J3/28 ,  G01J2003/062 ,  G01J2003/064 ,  G01J2003/065 ,  G01J2003/069 ,  G02B21/0028 ,  G02B21/0056 ,  G02B21/0064 ,  G02B21/0076 ,  G02B23/2453

Abstract: A scanning confocal microscopy system and apparatus, especially useful for endoscopy with a flexible probe which is connected to the end of an optical fiber (9). The probe has a grating (12) and a lens (14) which delivers a beam of multi-spectral light having spectral components which extend in one dimension across a region of an object and which is moved to scan in another dimension. The reflected confocal spectrum is measured to provide an image of the region.

Abstract translation: 一种扫描共焦显微镜系统和装置，其特别适用于连接到光纤端部（9）的柔性探头的内窥镜检查。 探针具有光栅（12）和透镜（14），其传送具有光谱分量的多光谱光束，该光谱分量在一个维度上跨过物体的区域延伸并且被移动以在另一维度上扫描。 测量反射共焦光谱以提供该区域的图像。

公开(公告)号：WO2011149972A3

公开(公告)日：2012-01-19

申请号：PCT/US2011037785

申请日：2011-05-24

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  YOO HONGKI ,  SHISHKOV MILEN ,  GARDECKI JOSEPH ,  SHUBOCHKIN ROMAN ,  MORSE THEODORE ,  JAFFER AMIN FAROUC

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  YOO HONGKI ,  SHISHKOV MILEN ,  GARDECKI JOSEPH ,  SHUBOCHKIN ROMAN ,  MORSE THEODORE ,  JAFFER AMIN FAROUC

IPC: A61B5/00 ,  G01B9/02 ,  G01N21/64

CPC classification number: A61B5/0084 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/6852 ,  G01B9/02029 ,  G01B9/0205 ,  G01B9/02091 ,  G01N21/4795 ,  G01N21/64 ,  G01N21/6456 ,  G01N21/65 ,  G01N2201/0866

Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.

Abstract translation: 描述了用于提供和/或利用光学频域成像（OFDI）和结构荧光以及例如使用OFDI技术和荧光成像技术的多模态成像的示例性系统，装置，方法，装置和计算机可访问介质。 例如，一种布置可以向解剖结构提供至少一个电磁辐射。 这种示例性布置可以包括至少一个光学芯和至少部分围绕光纤的至少一个包层。 光纤芯和包层之间的区域可以具有与光学芯和包层的折射率不同的折射率。 该装置还可以包括至少一个被配置为经由光学核和包层传播辐射到解剖结构的装置。

公开(公告)号：WO2011109835A3

公开(公告)日：2011-12-29

申请号：PCT/US2011027450

申请日：2011-03-07

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  GARDECKI JOSEPH A ,  LIU LINBO

IPC: A61B5/05 ,  A61B1/00 ,  G01B9/02

CPC classification number: A61B5/0066 ,  A61B5/0044 ,  A61B5/0075 ,  A61B5/0084 ,  G01B9/02091 ,  G02B6/32

Abstract: Exemplary embodiments of probes, apparatus, systems and methods can be provided which provide at least one electro-magnetic radiation to at least one sample. For example, a plurality of axicon lenses can be provided which are configured to provide the electro-magnetic radiation(s) having at least partially annulus shape. In addition or alternatively, at least one optical arrangement can be provided which is configured to forward at least one radiation to the sample therethrough having at least partially circularly-symmetric pattern. For example, at least one first portion of the radiation transmitted through a circular section of the pattern can have an optical path-length that is different from an optical path- length of at least one second portion of the radiation transmitted through at least one other section of the pattern.

Abstract translation: 可以提供探针，装置，系统和方法的示例性实施例，其向至少一个样品提供至少一个电磁辐射。 例如，可以提供多个旋转透镜，其构造成提供具有至少部分环形形状的电磁辐射。 另外或替代地，可以提供至少一个光学布置，其被配置为将至少一个辐射转发到具有至少部分圆对称图案的样品。 例如，透射通过图案的圆形部分的辐射的至少一个第一部分可以具有不同于透射通过至少一个其它的辐射的至少一个第二部分的光路长度的光路长度 部分图案。

公开(公告)号：WO2011044301A3

公开(公告)日：2011-06-30

申请号：PCT/US2010051715

申请日：2010-10-06

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  YOO HONGKI

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  KANG DONGKYUN ,  YOO HONGKI

IPC: A61B5/055 ,  A61B5/00

CPC classification number: A61B5/411 ,  A61B5/0062 ,  A61B5/0068 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/037 ,  A61B5/4233 ,  A61B5/68 ,  A61B5/6852 ,  A61B5/6853 ,  G02B21/0064 ,  G02B21/0076

Abstract: An exemplary embodiment of apparatus and method according to the present disclosure can be provided. For example, using at least one first arrangement, it is possible to direct at least one first electro-magnetic radiation to at least one portion of tissue within a body. Using at least one second arrangement, it is possible to receive at least one second electro-magnetic radiation provided from the portion, which is based on the first electro-magnetic radiation. Further, using at least one third arrangement, it is possible to differentiate at least one particular cell which is eosinophil, mast cell, basophil, monocyte and/or nutrophil from other cells in the portion based on the second electro-magnetic radiation.

Abstract translation: 可以提供根据本公开的设备和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一电磁辐射引导到身体内的组织的至少一部分。 使用至少一个第二布置，可以接收从基于第一电磁辐射的部分提供的至少一个第二电磁辐射。 此外，使用至少一种第三种布置，可以将基于第二电磁辐射的至少一种特定细胞（嗜酸性粒细胞，肥大细胞，嗜碱性粒细胞，单核细胞和/或嗜酸性粒细胞）与其他细胞区分开。

公开(公告)号：WO2008016927A2

公开(公告)日：2008-02-07

申请号：PCT/US2007074873

申请日：2007-07-31

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  MOTZ JASON T

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  MOTZ JASON T

IPC: G01N21/65

CPC classification number: G01J3/44 ,  A61B5/0075 ,  A61B5/0084 ,  G01J3/02 ,  G01J3/0218 ,  G01N21/65

Abstract: According to an exemplary embodiment, a system can be provided which can have at least one fiber arrangement and at least one receiving arrangement. The fiber arrangement may have optical transmitting characteristics, and may be configured to transmit there through at least one electromagnetic radiation and forward the at least one electromagnetic radiation to at least one sample. At least one portion of the fiber arrangement may be composed of or can include therein sapphire, diamond, clear graphite, Chalcogenide, borosilicate, zirconium fluoride, silver halide, a liquid core light guide, a gas core light guide, a hollow core waveguide, and/or a solid core photonic crystal fiber. The receiving arrangement may be configured to receive the electromagnetic radiation that is filtered and received from the sample. According to another exemplary embodiment, a method can be provided for obtaining information associated with the sample. For example, at least one first electromagnetic radiation can be forwarded to the sample via at least one optical fiber. At least one first characteristic of at least one portion of the optical fiber can be controlled so as to modify at least one second characteristic of at least one second electromagnetic radiation generated within the optical fiber. The second electromagnetic radiation can be associated with the first electromagnetic radiation.

Abstract translation: 根据示例性实施例，可以提供一种可以具有至少一个光纤布置和至少一个接收装置的系统。 光纤布置可以具有光学传输特性，并且可以被配置成通过至少一个电磁辐射传送到那里，并将至少一个电磁辐射转发到至少一个样本。 纤维布置的至少一部分可以由蓝宝石，金刚石，透明石墨，硫族化物，硼硅酸盐，氟化锆，卤化银，液芯导光体，气芯光导，中空芯波导， 和/或固体核心光子晶体光纤。 接收装置可以被配置为接收从样品过滤和接收的电磁辐射。 根据另一示例性实施例，可以提供用于获得与样本相关联的信息的方法。 例如，可以经由至少一根光纤将至少一个第一电磁辐射送到样品。 可以控制光纤的至少一部分的至少一个第一特征，以便修改在光纤内产生的至少一个第二电磁辐射的至少一个第二特性。 第二电磁辐射可以与第一电磁辐射相关联。

公开(公告)号：WO2007101026A3

公开(公告)日：2007-10-25

申请号：PCT/US2007062465

申请日：2007-02-21

Applicant: GEN HOSPITAL CORP ,  DESJARDINS ADRIEN E ,  VAKOC BENJAMIN J ,  TEANEY GUILLERMO J ,  BOUMA BRETT E

Inventor： DESJARDINS ADRIEN E ,  VAKOC BENJAMIN J ,  TEANEY GUILLERMO J ,  BOUMA BRETT E

IPC: G01B9/02 ,  A61B5/00 ,  G01N21/47

CPC classification number: G01N21/4795 ,  A61B5/0066 ,  A61B5/0073 ,  G01B9/02043 ,  G01B9/02087 ,  G01B9/02091 ,  G01B2290/70 ,  G01N2021/4714

Abstract: Angle-resolved Fourier-domain optical coherence tomography for measuring spatially-resolved angular backscattering distributions from transparent and turbid samples is presented. Speckle reduction and generating image contrast are shown. A wave length- swept laser source and line- scan camera are used. The input beam on the sample to be measured is collimated, with the reference beam being spatially expanded. The backscattered light from the sample interferes with the spatially expanded reference beam.

Abstract translation: 提出了用于测量透明和浊度样本的空间分辨角度后向散射分布的角度分辨傅立叶域光学相干断层扫描。 显示斑点减少和生成图像对比度。 使用波长扫描的激光源和扫描线相机。 要测量的样品上的输入光束被准直，参考光束在空间上展开。 来自样品的反向散射光干涉空间扩展的参考光束。

公开(公告)号：WO2007084933A3

公开(公告)日：2007-10-25

申请号：PCT/US2007060657

申请日：2007-01-18

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E

Inventor： TEARNEY GUILLERMO J ,  BOUMA BRETT E

IPC: G01N21/35

CPC classification number: G01N21/3563 ,  G01J3/02 ,  G01J3/021 ,  G01J3/42 ,  G01N21/031 ,  G01N21/45 ,  G01N21/4795 ,  G01N2021/1787

Abstract: Exemplary systems and processes for generating information associated with at least one portion of a sample are provided. In one exemplary embodiment, at least one electro-magnetic radiation can be received from the at least one portion, whereas the electro-magnetic radiation has a wavenumber that is between approximately 5,000 cm -1 and 600 cm -1 . The information can be generated which includes structural data, molecular data and/or chemical data of the portion. The information can be generated based on (a) at least one phase of the at least one electro-magnetic radiation, and/or (b) at least one refractive index of the at least one portion. According to another exemplary embodiment, the electro-magnetic radiation having a first wavenumber can be transmitted to the portion which has at least two substances, whereas a refractive index of one of the substances at a second wavenumber is approximately the same as a refractive index of another one of the substances at the second wavenumber. The electro-magnetic radiation can be controlled such that the first wavenumber substantially matches the first wavenumber to reduce scattering within the portion.

Abstract translation: 提供了用于产生与样本的至少一部分相关联的信息的示例性系统和过程。 在一个示例性实施例中，可以从至少一个部分接收至少一个电磁辐射，而电磁辐射具有在约5000cm -1至600cm -1之间的波数， SUP> -1 。 可以生成包括该部分的结构数据，分子数据和/或化学数据的信息。 可以基于（a）至少一个电磁辐射的至少一个相位和/或（b）至少一个部分的至少一个折射率来生成信息。 根据另一示例性实施例，具有第一波数的电磁辐射可以传输到具有至少两种物质的部分，而第二波数处的物质之一的折射率大致与折射率相同 第二个波数的另一个物质。 可以控制电磁辐射使得第一波数基本上与第一波数匹配以减少该部分内的散射。

公开(公告)号：WO2007084903A2

公开(公告)日：2007-07-26

申请号：PCT/US2007060608

申请日：2007-01-17

Applicant: GEN HOSPITAL CORP ,  SHISHKOV MILEN ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  YELIN DVIR ,  IFTIMIA NICUSOR

Inventor： SHISHKOV MILEN ,  TEARNEY GUILLERMO J ,  BOUMA BRETT E ,  YELIN DVIR ,  IFTIMIA NICUSOR

IPC: A61B1/00 ,  A61B5/00

CPC classification number: G01J3/18 ,  A61B1/00167 ,  A61B1/00188 ,  A61B1/002 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0068 ,  A61B5/0084 ,  A61B5/0086 ,  B24B9/14 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G02B5/18 ,  G02B23/2453 ,  G02B23/2469 ,  G02B23/26

Abstract: Exemplary apparatus for obtaining information for a structure can be provided. For example, the exemplary apparatus can include at least one first optical fiber arrangement which is configured to transceive at least one first electro-magnetic radiation, and can include at least one fiber. The exemplary apparatus can also include at least one second focusing arrangement in optical communication with the optical fiber arrangement. The second arrangement can be configured to focus and provide there through the first electro-magnetic radiation. Further, the exemplary apparatus can include at least one third dispersive arrangement which is configured to receive a particular radiation which is the first electro-magnetic radiation and/or the focused electro-magnetic radiation, and forward a dispersed radiation thereof to at least one section of the structure. At least one end of the fiber can be directly connected to the second focusing arrangement and/or the third dispersive arrangement. In addition, an exemplary embodiment of a method for producing an optical arrangement can be provided. For example, a first set of optical elements having a first size in a first configuration and a second set of optical elements in cooperation with the second set and having a second size in a second configuration can be provided. The first and second sets can be clamped into a third set of optical elements. The third set can be polished, and a further set of optical elements may be deposited on the polished set.

Abstract translation: 可以提供用于获得结构信息的示例性装置。 例如，示例性装置可以包括被配置为收发至少一个第一电磁辐射的至少一个第一光纤布置，并且可以包括至少一个光纤。 示例性装置还可以包括与光纤布置光学通信的至少一个第二聚焦装置。 第二布置可以被配置成通过第一电磁辐射聚焦并提供到那里。 此外，示例性装置可以包括至少一个第三分散装置，其被配置为接收作为第一电磁辐射和/或聚焦电磁辐射的特定辐射，并将其分散的辐射转发到至少一个部分 的结构。 光纤的至少一端可以直接连接到第二聚焦装置和/或第三色散装置。 此外，可以提供用于制造光学装置的方法的示例性实施例。 例如，可以提供具有第一配置的第一尺寸的第一组光学元件和与第二组配合并具有第二配置的第二尺寸的第二组光学元件。 第一组和第二组可以夹紧到第三组光学元件中。 可以抛光第三组，并且可以在抛光组上沉积另外的一组光学元件。

公开(公告)号：WO2007022220A2

公开(公告)日：2007-02-22

申请号：PCT/US2006031905

申请日：2006-08-16

Applicant: GEN HOSPITAL CORP ,  TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E

Inventor： TEARNEY GUILLERMO J ,  SHISHKOV MILEN ,  BOUMA BRETT E

IPC: A61B5/00

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/01 ,  A61B5/02007 ,  A61B5/061 ,  A61B5/1459 ,  A61B5/6855 ,  A61B5/6858 ,  A61B5/6859

Abstract: Apparatus, catheter and method for obtaining information regarding a tissue structure (e.g., a blood vessel) can be provided. For example, it is possible to utilize a transceiving arrangement which includes at least one section adapted to be provided in a proximity of at least one portion of the tissue structure and in a bodily fluid, and which is adapted to transmit and receive electro-magnetic radiation. The bodily fluid may be blood, pus, necrotic debris, mucus, urine and/or fecal matter.

Abstract translation: 可以提供用于获得关于组织结构（例如，血管）的信息的设备，导管和方法。 例如，可以利用收发装置，该收发装置包括至少一个适于设置在组织结构的至少一部分附近和体液中的部分，并且该收发装置适于发送和接收电磁 辐射。 体液可以是血液，脓液，坏死碎片，粘液，尿液和/或粪便物质。