公开(公告)号：HK81892A

公开(公告)日：1992-10-30

申请号：HK81892

申请日：1992-10-22

Applicant: HOECHST AG

Inventor： BOHN MANFRED DR ,  DITTMAR WALTER DR ,  PELL HEINZ GEORG DR ,  FUTTERER EBERHARD DR ,  KRAEMER KARL DR

IPC: A61K8/00 ,  A61K8/49 ,  A61K31/44 ,  A61Q3/02 ,  C07D213/89 ,  A61K7/043

Abstract: 1. An antimycotic nail varnish containing a) a 1-hydroxy-2-pyridone of the formula I see diagramm : EP0226984,P8,F2 in which R**1 is a saturated hydrocarbon radical having 6-9 carbon atoms, one of the radicals R**2 and R**4 is a hydrogen atom and the other is hydrogen, methyl or ethyl and R**3 is an alkyl radical having one or two carbon atoms, in the free form or in salt form, as the antimycotic substance, b) a water-insoluble film-forming agent, c) a physiologically acceptable solvent, and if appropriate d) additives customary in cosmetics.

公开(公告)号：DE3609597A1

公开(公告)日：1987-10-01

申请号：DE3609597

申请日：1986-03-21

Applicant: HOECHST AG

Inventor： KAMPE KLAUS-DIETER DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07D317/00 ,  A01N43/52 ,  A01N43/60 ,  A01N43/653 ,  A01N43/74 ,  A01N43/76 ,  C07D263/56 ,  C07D263/57 ,  C07D263/58 ,  C07D263/60 ,  C07D277/64 ,  C07D277/66 ,  C07D413/14 ,  C07D417/14 ,  C07D521/00 ,  C07D405/14 ,  C07D235/12 ,  C07D235/24 ,  C07D277/68 ,  A01N43/50

Abstract: Compounds of the formula I I and the acid-addition salts thereof, where A=CH or N; Ar=naphthyl, thienyl or phenyl; Z=oxygen or sulfur; R1=alkyl, F or Cl; g=0-2; L=0 or 1; m=0-4; p=0 or 1; X=O, S or N-R3; R2=alkyl, alkoxy, halogen, SCH3, COC6H5, CF3, COOCH3, COOC2H5, or NO2; n=0-2; R2, under certain circumstances, is alternatively -CH=CH-CH=CH- or phenoxy are described. Processes for the preparation thereof are also described. IIIa are valuable intermediates for the preparation of I. The compounds I serve as antimycotics.

公开(公告)号：DE3609596A1

公开(公告)日：1987-10-01

申请号：DE3609596

申请日：1986-03-21

Applicant: HOECHST AG

Inventor： KAMPE KLAUS-DIETER DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  HAENEL HEINZ DR

IPC: C07D247/00 ,  A01N43/60 ,  A01N43/653 ,  A61K31/44 ,  A61K31/443 ,  A61K31/47 ,  A61P25/08 ,  C07D213/72 ,  C07D213/85 ,  C07D215/54 ,  C07D237/34 ,  C07D239/14 ,  C07D239/42 ,  C07D317/00 ,  C07D333/00 ,  C07D405/14 ,  C07D521/00 ,  A01N43/56 ,  C07D213/74 ,  C07D215/46 ,  C07D237/30 ,  C07D239/70 ,  C07D409/14

公开(公告)号：DE3410070A1

公开(公告)日：1985-10-03

申请号：DE3410070

申请日：1984-03-20

Applicant: HOECHST AG

Inventor： BLUME ERNST DR ,  WINKELMANN ERHARDT DR ,  SCHAPER WOLFGANG DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07D521/00 ,  C07D405/06 ,  A61K31/41 ,  A61K31/495 ,  C07D401/14 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: Products of the formula I where E = N or CH, Ar = (substituted) phenyl, naphthyl or thienyl G = O, S, SO or SO2 n = 2-10 and L = or or radicals of some heterocycles, and a process for their preparation, pharmaceutical preparations based thereon, their use for the control of mycoses, protozoa and gram-positive and -negative bacteria are described; also intermediates of the formula I with -OH or the radical of a reactive ester instead of L.

公开(公告)号：GR77492B

公开(公告)日：1984-09-24

申请号：GR830171322

申请日：1983-05-11

Applicant: HOECHST AG

Inventor： WINKELMAMM ERHARD DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07D317/18 ,  C07D317/20 ,  C07D521/00

公开(公告)号：DE3308554A1

公开(公告)日：1984-09-13

申请号：DE3308554

申请日：1983-03-10

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG DR ,  BLUME ERNST DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P31/04 ,  A61P33/02 ,  C07D217/04 ,  C07D217/06 ,  C07D217/10 ,  C07D217/14 ,  C07D217/16 ,  C07D217/18 ,  C07D221/02 ,  C07D221/20 ,  C07D401/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D471/10 ,  C07D491/10 ,  C07D491/107 ,  C07D495/10 ,  C07D521/00 ,  C07D401/14 ,  C07D487/10 ,  A61K31/415 ,  A61K31/41

Abstract: New 1-(1,3-dioxolan-2-ylmethyl)azoles, their stereoisomers and their salts are described, as are processes for their preparation. The new compounds are chemotherapeutic agents. They are active against skin fungi, mold fungi and yeasts and against bacteria.

公开(公告)号：DE3239169A1

公开(公告)日：1984-04-26

申请号：DE3239169

申请日：1982-10-22

Applicant: HOECHST AG

Inventor： WINKELMANN ERHARDT DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07D317/18 ,  C07D317/20 ,  C07D521/00 ,  C07D405/06 ,  A01N43/50 ,  A01N43/64 ,  A61K7/40 ,  A61K31/41 ,  A61K31/415 ,  C07D405/12

Abstract: 1-(1,3-Dioxolan-2-ylmethyl)-1H-imidazoles and -1H-1,2,4-triazoles of the formula I and their salts with physiologically tolerable acids, and also processes for their preparation are described. These novel compounds act against fungal infections, in particular dermal mycoses, systemic mycoses and trichomoniasis.

公开(公告)号：DE3233604A1

公开(公告)日：1984-03-22

申请号：DE3233604

申请日：1982-09-10

Applicant: HOECHST AG

Inventor： WINGEN RAINER DR ,  DITTMAR WALTER DR ,  RAETHER WOLFGANG DR ,  SEIBERT GERHARD DR

IPC: C07D239/42 ,  C07D239/48 ,  C07D471/04 ,  A61K31/47

Abstract: Novel quaternary pyrimido[4,5-b]quinolinium salts of the general formula I and a process for their preparation are described. The novel compounds act against Gram-positive and Gram-negative bacteria, against fungi and against protozoa.

公开(公告)号：DE3140954A1

公开(公告)日：1983-05-05

申请号：DE3140954

申请日：1981-10-15

Applicant: HOECHST AG

Inventor： FUTTERER EBERHARD DIPL CHEM DR ,  DITTMAR WALTER DR ,  LIMBERT MICHAEL DIPL BIOL DR ,  HERZBERGER MONIKA ,  PEIL HEINZ-GEORG DR

IPC: A61K8/49 ,  A61K31/44 ,  A61Q19/00 ,  A61K7/48

Abstract: Use of 1-hydroxy-2-pyridones of the general formula I for the prophylaxis and treatment of acne and cosmetic or dermatological compositions which contain such compounds.

公开(公告)号：DE3018670A1

公开(公告)日：1981-11-26

申请号：DE3018670

申请日：1980-05-16

Applicant: HOECHST AG

Inventor： WINKELMANN ERHARDT DIPL CHEM D ,  DITTMAR WALTER DR ,  RAETHER WOLFGANG DR

IPC: C07D295/096 ,  C07C155/02 ,  A61K31/27

Abstract: Thiocarbamic acid esters of formula (I) are new. R1 is H, halo or alkyl hydroxyalkyl, alkoxy or alkylthio each with 1-4C in alkyl component; R2 is H, halo or alkyl, alkoxy or alkylthio, each with 1-4C in alkyl component; R3 is 1-4C alkyl; R4 is 2-6C straight chain, branched or cyclic alkyl substd. alkyl, alkylthio, hydroxyalkylthio, alkylsulphinyl, alkylcarbonyl, alkylcarbonyloxime, oxime (opt. substd.), alkyl carbonyl incorporating the benzene ring CN, carbamoyl, thiocarbamoyl, carboimidoether or carboimidothio ether. (I) are pharmaceuticals with an activity against fungal infections exceeding that of the known thiocarbamic acid ester, Tolnaflat. In vitro (I) are very effective against skin fungi such as Trichophyton mentagrophytes and Microsporum caris, or mould fungi such as Aspergillus niger. In vivo, e.g. experimental skin mycoses in guinea pigs, (I) are effective when used locally and can therefore be used to treat fungal diseases in humans and animals.