公开(公告)号：DE3410070A1

公开(公告)日：1985-10-03

申请号：DE3410070

申请日：1984-03-20

Applicant: HOECHST AG

Inventor： BLUME ERNST DR ,  WINKELMANN ERHARDT DR ,  SCHAPER WOLFGANG DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07D521/00 ,  C07D405/06 ,  A61K31/41 ,  A61K31/495 ,  C07D401/14 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

Abstract: Products of the formula I where E = N or CH, Ar = (substituted) phenyl, naphthyl or thienyl G = O, S, SO or SO2 n = 2-10 and L = or or radicals of some heterocycles, and a process for their preparation, pharmaceutical preparations based thereon, their use for the control of mycoses, protozoa and gram-positive and -negative bacteria are described; also intermediates of the formula I with -OH or the radical of a reactive ester instead of L.

公开(公告)号：DE3308554A1

公开(公告)日：1984-09-13

申请号：DE3308554

申请日：1983-03-10

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG DR ,  BLUME ERNST DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: A61K31/47 ,  A61K31/472 ,  A61P31/04 ,  A61P33/02 ,  C07D217/04 ,  C07D217/06 ,  C07D217/10 ,  C07D217/14 ,  C07D217/16 ,  C07D217/18 ,  C07D221/02 ,  C07D221/20 ,  C07D401/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D471/10 ,  C07D491/10 ,  C07D491/107 ,  C07D495/10 ,  C07D521/00 ,  C07D401/14 ,  C07D487/10 ,  A61K31/415 ,  A61K31/41

Abstract: New 1-(1,3-dioxolan-2-ylmethyl)azoles, their stereoisomers and their salts are described, as are processes for their preparation. The new compounds are chemotherapeutic agents. They are active against skin fungi, mold fungi and yeasts and against bacteria.

公开(公告)号：DE3608792A1

公开(公告)日：1987-09-24

申请号：DE3608792

申请日：1986-03-15

Applicant: HOECHST AG

Inventor： BLUME ERNST DR ,  SCHAPER WOLFGANG DR ,  EHRHARDT HEINZ DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  HAENEL HEINZ DR ,  SACHSE BURKHARD DR

IPC: C07D247/00 ,  A01N43/50 ,  A01N43/653 ,  C07C41/00 ,  C07C43/18 ,  C07C67/00 ,  C07C201/00 ,  C07C213/00 ,  C07C215/42 ,  C07C217/48 ,  C07C217/74 ,  C07C253/00 ,  C07C255/54 ,  C07C313/00 ,  C07C317/12 ,  C07C317/14 ,  C07C317/18 ,  C07C317/20 ,  C07C323/22 ,  C07D233/56 ,  C07D233/60 ,  C07D233/61 ,  C07D249/08 ,  C07D307/38 ,  C07D333/00 ,  C07D401/12 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D521/00 ,  A61K31/44 ,  A61K31/41 ,  C07D409/06 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: Compounds I I where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals -X-R1 where X=oxygen or sulfur and R1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals where R2 equals (cyclo)alkyl, acetyl or aryl; or Y equals -NR3R4 where R3/R4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides. They are obtained by reaction of II II with (CH3)2 III and further reaction of the compound IV obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent). The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.

公开(公告)号：DE4208254A1

公开(公告)日：1993-09-16

申请号：DE4208254

申请日：1992-03-14

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG DR ,  PREUSS RAINER DR ,  SALBECK GERHARD DR ,  BRAUN PETER DR ,  KNAUF WERNER DR ,  SACHSE BURKHARD DR ,  WALTERSDORFER ANNA DR ,  KERN MANFRED DR ,  LUEMMEN PETER ,  BONIN WERNER DR

IPC: A01N43/54 ,  A01N43/90 ,  A01P3/00 ,  A01P7/02 ,  A01P7/04 ,  C07D239/34 ,  C07D239/42 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D239/88 ,  C07D239/94 ,  C07D401/12 ,  C07D405/12 ,  C07D491/048 ,  C07D495/04

Abstract: Substituted 4-amino and 4-alkoxy cycloalkylpyrimidines, a method of producing them and their use as pesticides and fungicides. The invention concerns compounds of formula (I) wherein R , R , R and Q are defined as per the description, X represents NH or oxygen, and E represents a bond or a 1-4 member C-chain; a method of producing them, agents containing them and their use in combatting vermin and as a fungicide.

公开(公告)号：DE4131924A1

公开(公告)日：1993-07-08

申请号：DE4131924

申请日：1991-09-25

Applicant: HOECHST AG

Inventor： PREUSS RAINER DR ,  SALBECK GERHARD DR ,  SCHAPER WOLFGANG DR ,  BRAUN PETER DR ,  KNAUF WERNER DR ,  SACHSE BURKHARD DR ,  WALTERSDORFER ANNA DR ,  KERN MANFRED DR ,  LUMMEN PETER DR

IPC: A01N43/54 ,  A01N43/90 ,  C07D239/34 ,  C07D239/47 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D239/88 ,  C07D409/12 ,  C07D495/04 ,  C07F7/18

Abstract: The invention relates to substituted 4-alkoxypyrimidines of the formula in which R denotes hydrogen, halogen, alkyl or cycloalkyl, R denotes hydrogen, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted alkylthio, alkylamino or dialkylamino, R denotes hydrogen, alkyl, alkoxy, haloalkoxy, halogen, alkylthio, amino, alkylamino or dialkylamino and R denotes hydrogen, alkyl, cycloalkyl or haloalkyl, where R and R together with the C atoms carrying them can also form a ring and Q has the meanings defined in the description. The invention furthermore relates to a process for their preparation, agents containing them and their use as pesticides.

公开(公告)号：DE3608144A1

公开(公告)日：1987-09-24

申请号：DE3608144

申请日：1986-03-12

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG DR ,  FUSS ANDREAS DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  HAENEL HEINZ DR ,  GERHARDS HERMANN DR ,  SACHSE BURKHARD DR

IPC: A61K31/415 ,  A01N43/50 ,  A01N43/653 ,  A61P25/08 ,  A61P31/04 ,  A61P31/10 ,  A61P33/02 ,  C07D233/56 ,  C07D233/58 ,  C07D233/60 ,  C07D233/61 ,  C07D247/00 ,  C07D249/08 ,  C07D335/00 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00 ,  A61K31/41 ,  C07D409/08 ,  C07D495/04 ,  C07D409/12

Abstract: Azole compounds of the formula (I) in which A denotes CH or N, n = 1, 2 or 3, k = 1 or 2, Ar denotes a (subst.) aromatic radical or (subst.) thienyl, W denotes the atoms necessary to complete a benzene, naphthalene or thiophene ring system, X denotes a radical C(R )2 and in the case in which W denotes the atoms necessary to complete a benzene or naphthalene ring system, also denotes oxygen or sulphur, R and R denote H, halogen, (subst.) alkyl, cycloalkyl, alkoxy, alkylthio, cyano or nitro, and in the case in which W simultaneously denotes the atoms necessary to complete a benzene ring, R also denotes phenyl, phenoxy, phenylthio, phenylsulfinyl, phenylsulphonyl, benzyl, benzyloxy or hydroxyl, where the phenyl groups can be substituted or R and R together, if they are o-orientated, denote an alkylene chain; R denotes H or alkyl or two radicals R together, if they are bonded to the same C-atom, denote an alkylene chain, and their stereoisomers and salts have advantageous fungicidal, antimycotic and anticonvulsive effects.

公开(公告)号：DE3402166A1

公开(公告)日：1985-07-25

申请号：DE3402166

申请日：1984-01-23

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG DR ,  BLUME ERNST DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  ALPERMANN HANS GEORG DR ,  SACHSE BURKHARD DR ,  HARTZ PETER DR

IPC: A01N43/50 ,  A01N43/653 ,  A61K31/41 ,  A61K31/415 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  A61P31/04 ,  B27K3/38 ,  C07C45/60 ,  C07C49/84 ,  C07D233/60 ,  C07D249/08 ,  C07D295/096 ,  C07D295/185 ,  C07D333/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00 ,  C09D5/14 ,  C07D403/10

Abstract: Azolyl derivatives of the formula I where A = CH or N; n = 2 - 12; Ar = aromatic; R = alkyl, alkenyl, alkynyl or benzyl; and Q = -S(O)1-3R or -OR (R = alkyl, cycloalkyl, alkenyl and some aromatics; R = saturated or unsaturated alkyl, cycloalkyl, cycloalkylalkyl, aromatics) and processes for their preparation are described. They are antimicrobial agents active against fungal infections. The intermediates of the formula VIIa have antidepressive properties.

公开(公告)号：GR850174B

公开(公告)日：1985-05-13

申请号：GR850100174

申请日：1985-01-22

Applicant: HOECHST AG

Inventor： SCHAPER WOLFGANG DR ,  BLUME ERNST DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR ,  ALPERMANN HANS GEORG DR ,  SACHSE DURKARD DR ,  HARTZ PETER DR

IPC: A01N43/50 ,  A01N43/653 ,  A61K31/41 ,  A61K31/415 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  A61P31/04 ,  B27K3/38 ,  C07C45/60 ,  C07C49/84 ,  C07D233/60 ,  C07D249/08 ,  C07D295/096 ,  C07D295/185 ,  C07D333/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00 ,  C09D5/14

Abstract: Azolyl derivatives of the formula I where A = CH or N; n = 2 - 12; Ar = aromatic; R = alkyl, alkenyl, alkynyl or benzyl; and Q = -S(O)1-3R or -OR (R = alkyl, cycloalkyl, alkenyl and some aromatics; R = saturated or unsaturated alkyl, cycloalkyl, cycloalkylalkyl, aromatics) and processes for their preparation are described. They are antimicrobial agents active against fungal infections. The intermediates of the formula VIIa have antidepressive properties.

公开(公告)号：DE3039087A1

公开(公告)日：1982-05-19

申请号：DE3039087

申请日：1980-10-16

Applicant: HOECHST AG

Inventor： BLUME ERNST DR ,  SCHAPER WOLFGANG DR ,  RAETHER WOLFGANG DR ,  DITTMAR WALTER DR

IPC: C07D217/04 ,  C07D233/60 ,  C07D295/096 ,  C07D295/185 ,  C07D295/26 ,  C07D317/20 ,  C07D317/22 ,  C07D317/24 ,  C07D333/28 ,  C07D521/00 ,  C07D405/06 ,  C07D405/14 ,  A61K31/415 ,  A61K31/41

Abstract: 1-(1,3-Dioxolan-2-ylmethyl)-azoles of the general formula and their stereoisomers and their salts with physiologically acceptable acids, the preparation of these compounds, pharmaceutical formulations containing the latter and their use against mycoses, protozoa and Gram-positive and Gram-negative bacteria are described.

公开(公告)号：DE3902031A1

公开(公告)日：1990-07-26

申请号：DE3902031

申请日：1989-01-25

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD DR ,  KOTTMANN HARIOLF DR ,  SCHAPER WOLFGANG DR ,  STECHL JENS DR

IPC: C07D233/60 ,  C07D233/68 ,  C07D249/08 ,  C07D521/00

Abstract: Substituted azolylmethylcycloalkane derivatives of the formula I in which the substituents and symbols have the meanings indicated, possess an anticonvulsive and anxiolytic action and at the same time have low toxicity and neurotoxicity.