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    31.
    发明专利
    未知

    公开(公告)号：DK138542C

    公开(公告)日：1979-03-05

    申请号：DK220871

    申请日：1971-05-06

    Applicant: HOECHST AG

    Inventor： KUCH H ,  HOFFMANN I

    IPC: C07D243/12 ,  C07F9/53 ,  C07F9/645 ,  C07F9/65

    Abstract: Dialkylphosphinylalkylene-substituted 1,5-benzodiazepines useful as medicaments in the treatment of psychic diseases are obtainable by reacting the corresponding benzodiazepines with a dialkyl-phosphinylalkyl halide or by reacting a 2-dialkyl-phosphinylalkylaminodiphenylamine with a malonic acid dihalide or alkylmalonic acid dihalide.

    32.
    发明专利
    未知

    公开(公告)号：DK242078A

    公开(公告)日：1978-12-02

    申请号：DK242078

    申请日：1978-05-31

    Applicant: HOECHST AG

    Inventor： SCHMIDT K ,  HOFFMANN I ,  FUELBERTH W ,  STAMMBERGER W

    IPC: A61K31/47 ,  A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  A61K

    Abstract: What is disclosed are medicinal compositions, useful as anti-depressive agents, containing a compound of the formula; (I) in which R1, R3 and R4, which may be identical or different, and represent hydrogen atoms or lower alkyl or aralkyl groups, and R2 and R2', which may be identical or different, represent hydrogen or halogen atoms, hydroxy or trifluoromethyl groups or lower alkyl, alkoxy or aralkoxy groups, it also being possible that two adjacent radicals form an alkylene-dioxy radical, and R5 represents a hydrogen or halogen atom, a hydroxy, trifluoromethyl or nitro group or a lower alkyl, alkoxy or aralkoxy radical, and their salts with acids (active substance A) together with 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4 (3H,5H)-dione (active substance B), and their use as antidepressive agent.

    PHOSPHORUS-CONTAINING DERIVATIVES OF BENZO-1,5-DIAZEPINES
    35.
    发明专利
    PHOSPHORUS-CONTAINING DERIVATIVES OF BENZO-1,5-DIAZEPINES 未知

    公开(公告)号：GB1391288A

    公开(公告)日：1975-04-23

    申请号：GB1710172

    申请日：1972-04-13

    Applicant: HOECHST AG

    Inventor： KUCH H ,  HOFFMANN I

    IPC: C07F9/53 ,  C07F9/645 ,  C07D243/12 ,  C07F9/65 ,  A61K31/675

    Abstract: 1391288 Phosphorus-containing derivatives of benzo-1,5-diazepines HOECHST AG 13 April 1972 [15 April 1971] 17101/72 Heading C2P The invention comprises compounds of the general formula wherein R 1 and R 2 are selected from H, halogen, methoxy, ethoxy, N0 2 and CF 3 , R 3 is H, methyl, ethyl, n-propyl or isopropyl, R 4 and R 5 are selected from methyl, ethyl, n-propyl and isopropyl and n is 1, 2 or 3. They are obtained either (a) by reacting with wherein X is halogen or an alkyl- or arylsulphonic acid radical, the reaction being carried out in the presence of a metallizing agent, e.g. an alkali metal hydride, amide or alcoholate, or an alkaline earth metal hydride, the starting material II being optionally formed in situ by alkaline cyclization of a corresponding N-(2- aminophenyl)-N-phenyl malonic acid alkyl ester amide and then reacted, without isolation, with the compound III; or (b) by reacting a compound with a malonic acid dihalide or an appropriately substituted malonic acid dihalide. The products are suitable in the treatment of psychic diseases and may be administered in conventional pharmaceutical forms. The compounds of Formula IV may be obtained by reacting a correspondingly substituted 1-phenyl benz[(d)]imidazole with a compound III and then cleaving the imidazole ring by means of an alkali, an example being given for the production of 5-chloro-2-(dimethylphosphinylmethyl)amino diphenylamine and its corresponding substituted benzimidazolyl chloride precursor.

    36.
    发明专利
    未知

    公开(公告)号：DE2118262A1

    公开(公告)日：1972-11-02

    申请号：DE2118262

    申请日：1971-04-15

    Applicant: HOECHST AG

    Inventor： KUCH H ,  HOFFMANN I

    IPC: C07D243/12 ,  C07F9/53 ,  C07F9/645 ,  C07F9/28

    Abstract: Dialkylphosphinylalkylene-substituted 1,5-benzodiazepines useful as medicaments in the treatment of psychic diseases are obtainable by reacting the corresponding benzodiazepines with a dialkyl-phosphinylalkyl halide or by reacting a 2-dialkyl-phosphinylalkylaminodiphenylamine with a malonic acid dihalide or alkylmalonic acid dihalide.

    37.
    发明专利
    未知

    公开(公告)号：NL7204983A

    公开(公告)日：1972-10-17

    申请号：NL7204983

    申请日：1972-04-13

    Applicant: HOECHST AG

    Inventor： KUCH H ,  HOFFMANN I

    IPC: C07F9/53 ,  C07F9/645 ,  C07D243/12 ,  C07F9/28 ,  A61K27/00

    Abstract: Dialkylphosphinylalkylene-substituted 1,5-benzodiazepines useful as medicaments in the treatment of psychic diseases are obtainable by reacting the corresponding benzodiazepines with a dialkyl-phosphinylalkyl halide or by reacting a 2-dialkyl-phosphinylalkylaminodiphenylamine with a malonic acid dihalide or alkylmalonic acid dihalide.

    1,4,5,6,7,8-HEXAHYDROPYRAZOLO (3,4-B)(1,5)DIAZEPIN-5,7-DIONES
    38.
    发明专利
    1,4,5,6,7,8-HEXAHYDROPYRAZOLO (3,4-B)(1,5)DIAZEPIN-5,7-DIONES 未知

    公开(公告)号：NZ194633A

    公开(公告)日：1982-03-23

    申请号：NZ19463380

    申请日：1980-08-12

    Applicant: HOECHST AG

    Inventor： RACKUR G ,  HOFFMANN I

    IPC: A61K31/55 ,  A61P25/20 ,  C07D231/00 ,  C07D231/38 ,  C07D231/40 ,  C07D243/00 ,  C07D487/04

    Abstract: Compound of the general formula I in which R1 and R2 are identical or different and represent hydrogen atoms or alkyl groups with 1-6 C atoms, it also being possible for one of the radicals R1 and R2 to be, in each case, a benzyl, trifluoromethyl or phenyl group, R3 denotes a hydrogen atom, an alkyl group which has 1-6 C atoms and is optionally substituted by an aryl group, an alkoxy group with 1-6 C atoms, a trifluoromethyl group, a dialkylamino group with 2-12 C atoms or a cycloalkyl group with 3-6 C atoms, an alkenyl or alkynyl group with 2-6 C atoms, a cycloalkyl group with 3-6 C atoms or a carbalkoxy group with 2-6 C atoms, R4 is a hydrogen atom and R5 can be a phenyl group, a phenyl group which is monosubstituted or disubstituted by methyl Cl, Br, F, nitro, cyano and or trifluoromethyl or a pyridyl group and medicaments containing same.

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