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公开(公告)号：FI43719B
公开(公告)日：1971-03-01
申请号：FI215965
申请日：1965-09-08
Applicant: HOECHST AG
Inventor： HUBER G , SCHACHT U , TSCHESCHE R , DUPHORN I
Abstract: 1,126,196. Moenomycin A, B and C. FARBWERKE HOECHST A.G. 9 Dec., 1965 [10 Dec., 1964], No. 52310/65. Heading C2A. The antibiotic moenomycin (Specification 977,327) is separated into its components A, B and C by column chromatography on silica gel using as eluting agents mixtures of watermiscible alcohols and aqueous ammonia or aqueous C 1-4 amines. Mixtures of n-propanol and SN.NH 4 OH are preferred in which the content of NH 4 OH is increased. First impurities and then the components are eluted, and are recovered from pooled fractions by the addition of a non-solvent e.g. ether. Pharmaceutical compositions comprise monomycin A, B and C or a physiologically tolerable salt thereof, in admixture or conjunction with a phermaceutically suitable carrier.
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公开(公告)号：NZ217637A
公开(公告)日：1990-02-26
申请号：NZ21763786
申请日：1986-09-19
Applicant: HOECHST AG
Inventor： SIEGEL H , KAMPE K-D , ALPERMANN H G , GERHARDS H J , USINGER P , SCHACHT U , LEVEN M , RAETHER W , DITTMAR W , SACHSE B
IPC: A61K31/41 , A61K31/415 , C07D233/60 , C07D233/64 , C07D249/08 , C07D521/00 , C07D405/06
Abstract: Arylmethylazoles of the formula I I in which Aryl is (substituted) phenyl or naphthyl; Z is CH or N; R1 and Q are H or alkyl; R2 is H, alk(en)yl or alkynyl; R3 and R4 are H, alkyl or other hydrocarbons; or R3 and R4 together are a -(CH2)2-11 chain or a bridged -(CH2)4-5 chain, and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity. They are obtained, inter alia, from arylmethylazoles II II which are reacted with a strong base and then with a carbonyl compound III O=CR3R4; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R2Hal. If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomers are resolved.
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公开(公告)号：ZA783122B
公开(公告)日：1979-06-27
申请号：ZA783122
申请日：1978-05-30
Applicant: HOECHST AG
Inventor： HOFFMANN I , SCHACHT U , SCHMITT K
IPC: C07D217/18 , A61K31/47 , A61K31/472 , A61P25/24 , A61P25/26 , C07D217/04 , C07D , A61K
Abstract: 4-Phenyl-8-amino-tetrahydroisoquinolines of the formula in which R1 stands for bromine and R2 stands for hydrogen or both R1 and R2 represent chlorine, and their salts with physiologically tolerated acids, pharmaceutical preparations prepared therefrom, process for the manufacture of these preparations and their use for the treatment of depressive conditions.
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Patent Agency Ranking
公开(公告)号：ZA7803122B
公开(公告)日：1979-06-27
申请号：ZA7803122
申请日：1978-05-30
Applicant: HOECHST AG
Inventor： HOFFMANN I , SCHACHT U , SCHMITT K
IPC: C07D217/18 , A61K31/47 , A61K31/472 , A61P25/24 , A61P25/26 , C07D217/04 , C07D , A61K
CPC classification number: C07D217/04
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公开(公告)号：FI45565B
公开(公告)日：1972-04-04
申请号：FI221666
申请日：1966-08-24
Applicant: HOECHST AG
Inventor： SCHACHT U
IPC: A61K20060101 , C07G20060101 , C07G11/00 , C12D9/14 , C12D9/02
Abstract: 1,154,359. Hydrogenated moenomycins. FARBWERKE HOECHST A.G. 2 Sept., 1966 [3 Sept., 1965], No. 39324/66. Heading C2A. The antibiotic activity of moenomycin complex (Specification 977,327) or its components A, B and C against gram-positive pathogenic germs is enhanced by hydrogenation. The hydrogenation is carried out with the aid of precious metal catalysts (e.g. platinum) or Raney nickel in a polar solvent such as water, glacial acetic acid, methanol or dimethyl formamide. In the case of the hydrogenated moenomycin complex, the complex may be separated into the hydrogenated single components A, B and C by the process of Specification 1,126,196. Physical data for the hydrogenated compounds are provided. Pharmaceutical compositions comprise a carrier and a hydrogenated moenomycin complex or hydrogenated component A, B or C.
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公开(公告)号：AU517664B2
公开(公告)日：1981-08-20
申请号：AU3670578
申请日：1978-05-31
Applicant: HOECHST AG
Inventor： SCHMITT K , HOFFMANN L , SCHACHT U
IPC: C07D217/18 , A61K31/47 , A61K31/472 , A61P25/24 , A61P25/26 , C07D217/04 , C07D217/14 , C07C97/10 , A61K31/435
Abstract: 4-Phenyl-8-amino-tetrahydroisoquinolines of the formula in which R1 stands for bromine and R2 stands for hydrogen or both R1 and R2 represent chlorine, and their salts with physiologically tolerated acids, pharmaceutical preparations prepared therefrom, process for the manufacture of these preparations and their use for the treatment of depressive conditions.
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公开(公告)号：DK242278A
公开(公告)日：1978-12-02
申请号：DK242278
申请日：1978-05-31
Applicant: HOECHST AG
Inventor： SCHMITT K , HOFFMANN I , SCHACHT U
IPC: C07D217/18 , A61K31/47 , A61K31/472 , A61P25/24 , A61P25/26 , C07D217/04 , C07D
Abstract: 4-Phenyl-8-amino-tetrahydroisoquinolines of the formula in which R1 stands for bromine and R2 stands for hydrogen or both R1 and R2 represent chlorine, and their salts with physiologically tolerated acids, pharmaceutical preparations prepared therefrom, process for the manufacture of these preparations and their use for the treatment of depressive conditions.
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