公开(公告)号：DK0503162T3

公开(公告)日：1998-12-07

申请号：DK91122406

申请日：1992-01-01

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  ENGLERT HEINRICH DR ,  KLEEMANN HEINZ-WERNER DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD PROF DR ,  BECKER REINHARD DR ,  LINZ WOLFGANG DR ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K31/40 ,  A61K31/415 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/505 ,  A61K31/535 ,  A61K31/54 ,  A61K31/64 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D207/34 ,  C07D207/36 ,  C07D233/54 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D249/02 ,  C07D255/02 ,  C07D257/02 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D453/02 ,  C07D521/00

Abstract: Azole derivative of the general formula (I) in which A, L, O, R , X, Y, Z and q have the meanings given, a process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have, for example, the following meanings: R = (C2-C10)-alkyl Z = nitrogen X and Y = independently of one another CR L = -CH2- q = zero or 1 A = biphenyl radical which is substituted, for example, by R R = halogen or hydrogen R = SO2-NH-CO-OR and R = phenyl, are highly active antagonists of angiotensin II receptors.

公开(公告)号：DE19712636A1

公开(公告)日：1998-10-01

申请号：DE19712636

申请日：1997-03-26

Applicant: HOECHST AG

Inventor： LANG HANS JOCHEN DR ,  JANSEN HANS-WILLI DR ,  SCHWARK JAN-ROBERT DR ,  KLEEMANN HEINZ-WERNER DR ,  JUNG OLIVER ,  SCHAEFER HANS-LUDWIG DR ,  LINZ WOLFGANG DR ,  KRAMER WERNER PROF DR DR ,  SCHOELKENS BERNWARD PROF DR ,  FALK EUGEN DR

IPC: A61K31/166 ,  A61K31/155 ,  A61K31/415 ,  A61K31/42 ,  A61K31/425

Abstract: Use of sodium/proton exchange inhibitors in the preparation of a medicament for treatment of raised blood lipid levels is new.

公开(公告)号：ID19574A

公开(公告)日：1998-07-23

申请号：ID980065

申请日：1998-01-20

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  FABER AP SABINE ,  JANSEN HANS-WILLI DR

IPC: C07D233/60 ,  A01N1/02 ,  A61K31/415 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/61 ,  C07D233/64 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D233/00 ,  A61K31/41

Abstract: 1-Benzylimidazole derivatives of formula (I) and their salts are new. R1 = H, 1-8C alkyl, -CaH2a-Ar or -CaH2a-(3-7C)cycloalkyl; a = 0-2; Ar = phenyl or 1-9C heteroaryl (both optionally substituted by 1-3 F, Cl, Br, I, CF3, Me, OMe, OH or NR8R9); R8, R9 = H or 1-4C alkyl; R2, R3 = H, F, Cl, Br, I, CF3, CN, NO2, CH2OR17, COR6 or OR7, 1-8C alkyl, 3-7C cycloalkyl, -CaH2a-Ar or -SOa-R22; R17= H or 1-8C alkyl; R6 = H, 1-8C alkyl, OR30 or phenyl (optionally substituted as in Ar); R7 = H, 1-8C alkyl or Ar; R22 = 1-8C alkyl, 3-7C cycloalkyl or -CaH2a-Ph; R4, R5 = H, 1-8C alkyl, F, Cl, Br, I, CF3, CN, NO2, SOa-R16, COR23 or OR24; R16 = 1-8C alkyl or phenyl (optionally substituted as in Ar); R23 = H, 1-8C alkyl or OR25; R24 = H, 1-8C alkyl or phenyl (optionally substituted as in Ar); and R25 = H or 1-8C alkyl. Also claimed is the treatment or prophylaxis of ischaemia-mediated conditions or the treatment of respiratory disorders using a tetrazole derivative.

公开(公告)号：ID19397A

公开(公告)日：1998-07-09

申请号：ID980454

申请日：1998-03-30

Applicant: HOECHST AG

Inventor： WEICHERT ANDREAS DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/155 ,  A61K31/165 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  C07C279/10 ,  C07C279/20 ,  C07C279/22 ,  C07C ,  A61K ,  A01N

Abstract: Benzoyl-guanidines of formula (I) and their salts are new. One of R2,R3 = H; and the other = -C(OH)MeCH2OH, -CHMeCH2OH or -C(OH)(Me)2; and R4 = Me, OMe, Cl or CF3 (preferably Me).

公开(公告)号：ES2115115T3

公开(公告)日：1998-06-16

申请号：ES94112383

申请日：1994-08-08

Applicant: HOECHST AG

Inventor： SCHWARK JAN-ROBERT DR ,  LANG HANS-JOCHEN DR ,  KLEEMANN HEINZ-WERNER DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: A61K31/155 ,  A61K31/17 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/535 ,  A61K31/5375 ,  A61P1/16 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07C277/08 ,  C07C279/22 ,  C07C327/48 ,  C07C335/16 ,  C07C335/22 ,  C07D295/195 ,  C07D295/20 ,  C07D295/215

公开(公告)号：CZ338396A3

公开(公告)日：1998-05-13

申请号：CZ338396

申请日：1996-11-18

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  BRENDEL JOACHIM DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  LANG HANS JOCHEM DR ,  ALBUS UDO DR ,  SCHOLZ WOLFGANG DR

IPC: A61K31/165 ,  A61P1/16 ,  A61P3/08 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07C279/20 ,  C07C279/22

Abstract: Benzenedicarboxylic acid diguanidides of formula (I) are new: one of R1, R2, R3 and R5 = -CO-N=C(NH2)2 and the others are as follows: R1 and R5 = H, 1-4C alkyl, F, etc.;R2 = H, halo, OH, CN, CF3, CO-N=C(NH2)2, 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, SO2R22, CONR23R24, COR28, SO2NR29R30, OR35 or NR35R36; and R3 = H, SR25, OR25, NR25R26 or CR25R26R27; while R4 = e.g. CF3; m = 0-2; R14 = e.g. 3-8C cycloalkyl; R22, R28 = e.g. Me; R23, R24, R29, R30 = e.g. H; R35, R36 = H or 1-6C alkyl; or R35+R36 = e.g. 4-7 CH2 gps.; R25 = H, 1-8C alkyl, etc.; R26, R27 = H, 1-8C alkyl or groups as defined for R25.

公开(公告)号：DK0627413T3

公开(公告)日：1998-04-14

申请号：DK94108281

申请日：1994-05-30

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR ,  KLEEMANN HEINZ-WERNER DR

IPC: A61K31/165 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  C07C277/08 ,  C07C279/22 ,  C07C311/15 ,  C07C317/44 ,  C07C317/46 ,  C07C323/62 ,  C07D241/28

Abstract: There are described benzoylguanidines of the formula I where R(1) is H, Hal, -NO2, -C IDENTICAL N, Xo-(CH2)p-(CF2)q-CF3, R(5)- SOm, R(6)-CO- or R(6)R(7)NO-SO2-, where X is O, S, NR(14), m is 0-2, o is 0, 1, p is 0-2, q is 0-6, R(5) and R(6) are alk(en)yl, -CnH2n-R(8), CF3, n is 0-4, R(8) is cycloalkyl, phenyl, R(6) also being H, R(2) is where Y is O, -S- or -NR(12)-; R(11), R(12) = H, alkyl, and h is zero or 1, and i, j and k are 0-4, but where h, i and k are not simultaneously zero, R(3) is defined as R(1), or is alkyl, -X-R(13) where X is O, S, NR(14), R(14) is H, alkyl, R(13) is H, (cyclo)alkyl, -CbH2b-R(15) where b is 0-4, R(15) is phenyl, R(4) is H, -OR(16) or -NR(16)R(17) where R(16), R(17) are H, alkyl and their pharmaceutically tolerable salts. They are obtained from a compound II by reaction with guanidine, in which R(1) to R(4) have the meaning indicated and L is a leaving group which can be easily nucleophilically substituted. The compounds are outstandingly suitable as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and infarct treatment and also for the treatment of angina pectoris, where they also preventively inhibit or severely decrease the pathophysiological processes in the formation of ischaemically induced damage, in particular in the elicitation of ischaemically induced cardiac arrhythmias.

公开(公告)号：GR3025798T3

公开(公告)日：1998-03-31

申请号：GR970403444

申请日：1997-12-30

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

IPC: C07D233/64 ,  A01N1/02 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61P1/16 ,  A61P3/10 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P13/02 ,  A61P13/08 ,  A61P13/12 ,  A61P15/00 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C279/22 ,  C07D207/333 ,  C07D207/337 ,  C07D213/30 ,  C07D231/12 ,  C07D233/54 ,  C07D233/58 ,  C07D521/00

Abstract: The invention relates to benzoylguanidines of the formula I where R(1) is H, Hal, -NO2, -C IDENTICAL N, Xo-(CH2)p-(CF2)q-CF3, R(5)SOm, R(6)-CO-, R(6)R(7)N-CO- or R(6)R(7)N-SO2-, where X is oxygen, S, NR(14), m is zero, 1 or 2, o is zero, 1, p is zero, 1, 2, q is zero, 1, 2, 3, 4, 5, 6, R(5) and R(6) are alk(en)yl, -CnH2n-R(8), CF3, n is zero, 1, 2, 3 or 4, R(8) is cycloalkyl, phenyl, where R(6) also has the meaning of H, R(7) is H or alkyl; R(2) is R(11) is (C1-C9)-heteroaryl, Y is oxygen, -S- or NR(12)-, R(12) is H, (C1-C4)-alkyl; R(3) is defined as R(1), or is alkyl, -X-R(13) where X is oxygen, S, NR(14), R(14) is H, (C1-C3)-alkyl, R(13) is H, (cyclo)alkyl, -CbH2b-R(15) where b is zero to 4 and R(15) is phenyl; R(4) is hydrogen, -OR(16), -NR(16)R(17) or CrF2r+1 where R(16), R(17) independently are hydrogen, (C1-C3)-alkyl, r is 1-4 and their pharmaceutically tolerable salts. The compounds I are outstandingly suitable as antiarrhythmic medicaments having a cardioprotective component for infarct prophylaxis and for infarct treatment and for the treatment of angina pectoris.

公开(公告)号：DK0612723T3

公开(公告)日：1998-03-30

申请号：DK94102322

申请日：1994-02-16

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR ,  WEICHERT ANDREAS DR ,  LANG HANS-JOCHEN DR ,  SCHWARK JAN-ROBERT DR

IPC: A61K31/165 ,  A61K31/155 ,  A61K31/166 ,  A61K31/44 ,  A61K31/47 ,  A61K31/472 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P7/02 ,  A61P9/00 ,  A61P9/02 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/08 ,  A61P13/12 ,  A61P35/00 ,  A61P43/00 ,  C07C233/65 ,  C07C277/08 ,  C07C279/18 ,  C07C279/22 ,  C07D213/30 ,  C07D213/56 ,  C07D215/14 ,  C07D215/50 ,  C07D217/18 ,  C07D217/24

公开(公告)号：CZ9702659A3

公开(公告)日：1998-03-18

申请号：CZ265997

申请日：1997-08-20

Applicant: HOECHST AG

Inventor： SCHWARK JAN-ROBERT DR ,  BRENDEL JOACHIM DR ,  KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  WEICHERT ANDREAS DR ,  JANSEN HANS-WILLI DR ,  SCHOLZ WOLFGANG DR

IPC: C07D213/65 ,  A01N1/00 ,  A61K31/155 ,  A61K31/165 ,  A61K31/44 ,  A61K31/4406 ,  A61P3/06 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P43/00 ,  C07C277/08 ,  C07C279/20 ,  C07C279/22

CPC classification number: C07C279/22 ,  Y10S514/821 ,  Y10S514/866 ,  Y10S514/921