公开(公告)号：MY121708A

公开(公告)日：2006-02-28

申请号：MYPI9800237

申请日：1998-01-21

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  FABER AP SABINE ,  JANSEN HANS-WILLI DR

IPC: C07D233/60 ,  C07D233/84 ,  A01N1/02 ,  A61K31/415 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/61 ,  C07D233/64 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/74 ,  C07D233/88 ,  C07D233/90

Abstract: COMPOUNDS OF THE FORMULA I FORMULA I IN WHICH THE SYMBOLS HAVE THE MEANINGS INDICATED IN THE CLAIMS, HAVE OUTSTANDING ANTIARRHYTHMIC PROPERTIES AND EXHIBIT A CARDIOPROTECTIVE COMPONENT. THEY CAN PREVENTIVELY INHIBIT OR GREATLY DECREASE THE PATHOPHYSIOLOGICAL PROCESSES IN THE FORMATION OF ISCHEMICALLY INDUCED DAMAGE, IN PARTICULAR IN THE ELICITATION OF ISCHEMICALLY INDUCED CARDIAC ARRHYTHMIAS. MOREOVER, THEY HAVE A POTENT INHIBITORY ACTION ON THE PROLIFERATION OF CELLS.

公开(公告)号：ID19574A

公开(公告)日：1998-07-23

申请号：ID980065

申请日：1998-01-20

Applicant: HOECHST AG

Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  FABER AP SABINE ,  JANSEN HANS-WILLI DR

IPC: C07D233/60 ,  A01N1/02 ,  A61K31/415 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P43/00 ,  C07D233/54 ,  C07D233/61 ,  C07D233/64 ,  C07D233/66 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  C07D233/00 ,  A61K31/41

Abstract: 1-Benzylimidazole derivatives of formula (I) and their salts are new. R1 = H, 1-8C alkyl, -CaH2a-Ar or -CaH2a-(3-7C)cycloalkyl; a = 0-2; Ar = phenyl or 1-9C heteroaryl (both optionally substituted by 1-3 F, Cl, Br, I, CF3, Me, OMe, OH or NR8R9); R8, R9 = H or 1-4C alkyl; R2, R3 = H, F, Cl, Br, I, CF3, CN, NO2, CH2OR17, COR6 or OR7, 1-8C alkyl, 3-7C cycloalkyl, -CaH2a-Ar or -SOa-R22; R17= H or 1-8C alkyl; R6 = H, 1-8C alkyl, OR30 or phenyl (optionally substituted as in Ar); R7 = H, 1-8C alkyl or Ar; R22 = 1-8C alkyl, 3-7C cycloalkyl or -CaH2a-Ph; R4, R5 = H, 1-8C alkyl, F, Cl, Br, I, CF3, CN, NO2, SOa-R16, COR23 or OR24; R16 = 1-8C alkyl or phenyl (optionally substituted as in Ar); R23 = H, 1-8C alkyl or OR25; R24 = H, 1-8C alkyl or phenyl (optionally substituted as in Ar); and R25 = H or 1-8C alkyl. Also claimed is the treatment or prophylaxis of ischaemia-mediated conditions or the treatment of respiratory disorders using a tetrazole derivative.