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    CROSSLINKED POLYMERS,A PROCESS FOR THEIR PREPARATION,AND THEIR USE
    33.
    发明专利
    CROSSLINKED POLYMERS,A PROCESS FOR THEIR PREPARATION,AND THEIR USE 未知

    公开(公告)号：ZA849660B

    公开(公告)日：1985-07-31

    申请号：ZA849660

    申请日：1984-12-12

    Applicant: HOECHST AG

    Inventor： MAUZ OTTO ,  NOETZEL SIEGFRIED ,  NEUMANN BERNHARD

    IPC: A61K38/46 ,  A61K39/00 ,  A61K39/44 ,  A61K47/00 ,  A61K47/32 ,  B01D15/08 ,  B01J20/26 ,  B01J20/281 ,  B01J20/285 ,  C08F2/00 ,  C08F2/18 ,  C08F8/00 ,  C08F8/12 ,  C08F16/02 ,  C08F16/32 ,  C08F18/02 ,  C08F22/18 ,  C08F26/00 ,  C08F26/10 ,  C08F216/06 ,  C08F216/12 ,  C08F218/00 ,  C08F218/02 ,  C08F218/04 ,  C08F218/08 ,  C08F226/06 ,  C08J9/224 ,  C12N11/08 ,  G01N30/88 ,  G01N33/543 ,  C08F ,  B01J ,  B01D ,  A61K ,  C12N

    Abstract: For the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A crosslinked polymer in the form of beads which substantially comprises vinyl acylate units and units of a crosslinking agent which has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, the amount of theses crosslinking agent units accounting for 1 to 60 % by weight of the polymer, the acyloxy groups of the vinyl acylate units being present as such or having been partially or completely replaced by hydroxyl groups, and the average particle size of the beads being 20 to 800 mu m and the mean pore diameter being 2 to 10,000 nm. For the contracting state AT 1. A process for preparing a crosslinked polymer in the form of beads by copolymerizing vinyl acylate with a crosslinking agent and, if propriate, a further monomer copolymerizable with the vinyl acylate in ther presence of a dispersion medium and if desired partially or completely hydrolyzing the resulting polymer, wherein the crosslinking agent has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, and the beads obtained have an average particle size of 10 to 800 mu m and an average pore diameter of 2 to 10,000 nm.

    35.
    发明专利
    未知

    公开(公告)号：FI844889A0

    公开(公告)日：1984-12-11

    申请号：FI844889

    申请日：1984-12-11

    Applicant: HOECHST AG

    Inventor： MAUZ OTTO ,  NOETZEL SIEGFRIED ,  NEUMANN BERNHARD

    IPC: A61K38/46 ,  A61K39/00 ,  A61K39/44 ,  A61K47/00 ,  A61K47/32 ,  B01D15/08 ,  B01J20/26 ,  B01J20/281 ,  B01J20/285 ,  C08F2/00 ,  C08F2/18 ,  C08F8/00 ,  C08F8/12 ,  C08F16/02 ,  C08F16/32 ,  C08F18/02 ,  C08F22/18 ,  C08F26/00 ,  C08F26/10 ,  C08F216/06 ,  C08F216/12 ,  C08F218/00 ,  C08F218/02 ,  C08F218/04 ,  C08F218/08 ,  C08F226/06 ,  C08J9/224 ,  C12N11/08 ,  G01N30/88 ,  G01N33/543 ,  C08F

    Abstract: For the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE 1. A crosslinked polymer in the form of beads which substantially comprises vinyl acylate units and units of a crosslinking agent which has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, the amount of theses crosslinking agent units accounting for 1 to 60 % by weight of the polymer, the acyloxy groups of the vinyl acylate units being present as such or having been partially or completely replaced by hydroxyl groups, and the average particle size of the beads being 20 to 800 mu m and the mean pore diameter being 2 to 10,000 nm. For the contracting state AT 1. A process for preparing a crosslinked polymer in the form of beads by copolymerizing vinyl acylate with a crosslinking agent and, if propriate, a further monomer copolymerizable with the vinyl acylate in ther presence of a dispersion medium and if desired partially or completely hydrolyzing the resulting polymer, wherein the crosslinking agent has the formulae see diagramm : EP0150350,P12,F1 and/or see diagramm : EP0150350,P12,F2 where R1 and R2 in the formula (I) can be identical or different and each denotes vinyl-, 1-acyloxyvinyl, allyl- or 2-acyloxyallyl, A represents a divalent hydrocarbon radical of 2 to 8 carbon atoms, B in the formula (II) stands for a divalent hydrocarbon radical of 1 to 8 carbon atoms and X denotes acyloxy, and the beads obtained have an average particle size of 10 to 800 mu m and an average pore diameter of 2 to 10,000 nm.

    METABOLICALLY ACTIVE DERIVATIVES OF BIS (4-HYDROXY-PHENYL) ALKANOIC ACID AND PROCESS FOR THEIR MANUFACTURE
    37.
    发明专利
    METABOLICALLY ACTIVE DERIVATIVES OF BIS (4-HYDROXY-PHENYL) ALKANOIC ACID AND PROCESS FOR THEIR MANUFACTURE 未知

    公开(公告)号：CA1014857A

    公开(公告)日：1977-08-02

    申请号：CA173467

    申请日：1973-06-07

    Applicant: HOECHST AG

    Inventor： MAUZ OTTO ,  GRANZER ERNOLD

    IPC: C07C59/52

    Abstract: Pharmaceutical compositions acting on the metabolism which contain as active substance bis(4-hydroxy-phenyl)alkanoic acids corresponding to the formulae I and II wherein R1 and R2 wich may be identical or different, each stands for a hydrogen or halogen atom or an alkyl group having 1 to 4 carbon atoms, R3 stands for a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R4 stands for hydroxy, alkoxy having 1 to 18 carbon atoms, phenyl-alkoxy having 1 to 4 alkyl carbon atoms, cycloalkoxy having 5 to 8 carbon atoms or a group of the formula in which Z and Z', which may be identical or different, each stands for hydrogen, alkyl of 1 to 18 carbon atoms, phenyl or cycloalkyl of 5 to 8 carbon atoms, or both together with the nitrogen atom may form a heterocyclic ring, R6 stands for an alkylene radical having 2 to 12 atoms and n stands for zero or an integer of 1 to 6, and process for preparing them.

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