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公开(公告)号：HK1171449A1
公开(公告)日：2013-03-28
申请号：HK12112260
申请日：2012-11-28
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： MACDONALD GREGOR JAMES , DE BOECK BENOT CHRISTIAN ALBERT GHISLAIN , LEENAERTS JOSEPH ELISABETH
IPC: C07D20060101 , A61K20060101 , A61P20060101
Abstract: The present invention relates to morpholinothiazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulators having the capability to increase the efficacy of nicotinic receptor agonists.
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公开(公告)号：AU2008240728B2
公开(公告)日：2013-01-10
申请号：AU2008240728
申请日：2008-04-18
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： MACDONALD GREGOR JAMES , BARTOLOME-NEBREDA JOSE MANUEL
IPC: C07D401/12 , A61K31/501 , A61P25/18
Abstract: The present invention relates to (1-benzyl-piperidin-4-yl) - (4-alkoxy-pyridazin-3-yl) - amines of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
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33.发明专利
公开(公告)号：PT2148873E
公开(公告)日：2012-11-20
申请号：PT08749604
申请日：2008-04-18
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： BARTOLOME-NEBREDA JOSE MANUEL , MACDONALD GREGOR JAMES
IPC: C07D401/12 , A61K31/501 , A61P25/18
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公开(公告)号：DK2121630T3
公开(公告)日：2012-11-12
申请号：DK08716791
申请日：2008-02-11
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： MACDONALD GREGOR JAMES , LANGLOIS XAVIER JEAN MICHEL , BARTOLOME-NEBREDA JOSE MANUEL , VAN GOOL MICHIEL LUC MARIA
IPC: C07D237/20 , A61K31/495 , A61P25/18 , C07D237/24 , C07D409/04 , C07D487/04
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公开(公告)号：SG183524A1
公开(公告)日：2012-09-27
申请号：SG2012063764
申请日：2011-03-08
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： BARTOLOME-NEBREDA JOSE MANUEL , CONDE-CEIDE SUSANA , MACDONALD GREGOR JAMES , PASTOR-FERNANDEZ JOAQUIN , VAN GOOL MICHIEL LUC MARIA , MARTIN-MARTIN MARIA LUZ , VANHOOF GRETA CONSTANTIA PETER
Abstract: The present invention relates to novel imidazo[1,2-a]pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which are useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.
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Patent Agency Ranking36.发明专利
公开(公告)号：HK1159083A1
公开(公告)日：2012-07-27
申请号：HK11113345
申请日：2011-12-09
Applicant: JANSSEN PHARMACEUTICA NV
IPC: C07D20060101 , A61K20060101 , A61P20060101
Abstract: The present invention relates to piperazin-1-yl-trifluoromethyl-substituted-pyridines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
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37.发明专利
公开(公告)号：UA98940C2
公开(公告)日：2012-07-10
申请号：UAA200903503
申请日：2007-12-05
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： MACDONALD GREGOR JAMES , ANDRES-GIL JOSE IGNACIO , VAN DEN KEYBUS FRANS ALFONS MA , BARTOLOME-NEBREDA JOSE MANUEL , VAN GOOL MICHIEL LUC MARIA
IPC: C07D401/12 , A61K31/501 , A61P25/18
Abstract: Представленноеизобретениекасается 6-(пиперидин-4-иламино)пиридазин-3-карбонитриловформулы (I)(I),которыеявляютсябыстродиссоциирующимиантагонистамирецепторовдопамина 2, способовполученияэтихсоединений, фармацевтическихкомпозиций, которыесодержатэтисоединениякакактивныйкомпонент; атакжепримененияихв качествелекарственныхсредствдлялеченияилипредупреждениярасстройствцентральнойнервнойсистемы, напримершизофрении, демонстрируяантипсихотическоедействиебезмоторныхпобочныхэффектов.
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公开(公告)号：AU2010332819A1
公开(公告)日：2012-06-21
申请号：AU2010332819
申请日：2010-12-16
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： MACDONALD GREGOR JAMES , TRESADERN GARY JOHN , TRABANCO-SUAREZ ANDRES AVELINO , PASTOR-FERNANDEZ JOAQUIN
IPC: C07D513/04 , A61K31/428 , A61K31/429 , A61P25/18
Abstract: The present invention relates to novel bicyclic thiazoles of formula (I) which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5") and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.
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39.发明专利
公开(公告)号：CA2799635A1
公开(公告)日：2011-12-15
申请号：CA2799635
申请日：2011-06-07
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： TRABANCO-SUAREZ ANDRES AVELINO , TRESADERN GARY JOHN , MACDONALD GREGOR JAMES , VEGA RAMIRO JUAN ANTONIO
IPC: C07D401/10 , A61K31/496 , A61P25/16 , A61P25/28 , C07D401/12 , C07D403/10
Abstract: The present invention relates to novel 5-amino-3,6-dihydro-1H-pyrazin-2-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretaseis involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease or dementia associated with beta-amyloid.
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公开(公告)号：CA2782950A1
公开(公告)日：2011-06-23
申请号：CA2782950
申请日：2010-12-16
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： MACDONALD GREGOR JAMES , TRABANCO-SUAREZ ANDRES AVELINO , CONDE-CEIDE SUSANA , TRESADERN GARY JOHN , BARTOLOME-NEBREDA JOSE MANUEL , PASTOR-FERNANDEZ JOAQUIN
IPC: C07D513/04 , A61K31/428 , A61K31/429 , A61P25/18
Abstract: The present invention relates to novel bicyclic thiazoles of formula (I) which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5") and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.
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