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    Antiinflammatory agents
    36.
    发明专利
    Antiinflammatory agents 有权
    抗炎药

    公开(公告)号：JP2014101329A

    公开(公告)日：2014-06-05

    申请号：JP2012255386

    申请日：2012-11-21

    Applicant: Kao Corp ,  花王株式会社

    Inventor： KUWANO TETSUYA ,  WATANABE MANABU ,  MURASE TAKATOSHI

    IPC: A61K31/12 ,  A61P29/00 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To provide novel antiinflammatory agents useful as antiinflammatory agents whose inflammatory cytokine expression inhibitory action and prostaglandin production inhibitory action are sufficiently strong.SOLUTION: An antiinflammatory agent comprises a methoxychalkone represented by the specified general formula as an active ingredient. (In the formula, Rand Reach represent a hydrogen atom or a methyl group.)

    Abstract translation: 要解决的问题：提供可用作抗炎剂的新型抗炎剂，其抗炎症细胞因子表达抑制作用和前列腺素产生抑制作用足够强。解决方案：抗炎剂包含由指定的通式表示的甲氧基酮酮作为活性成分。 （在该式中，Rand Reach表示氢原子或甲基。）

    Method for searching differentiated maturity inhibitor for fat cell and/or fat accumulation inhibitor
    38.
    发明专利
    Method for searching differentiated maturity inhibitor for fat cell and/or fat accumulation inhibitor 有权
    搜索FAT细胞和/或脂肪蓄积抑制剂的差异成熟抑制剂的方法

    公开(公告)号：JP2013036797A

    公开(公告)日：2013-02-21

    申请号：JP2011171659

    申请日：2011-08-05

    Applicant: Kao Corp ,  花王株式会社

    Inventor： URANO SATOMI ,  MORI SHINOBU ,  MURASE TAKATOSHI

    IPC: G01N33/50 ,  A61K45/00 ,  A61P3/06 ,  C07K14/78 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15

    Abstract: PROBLEM TO BE SOLVED: To provide a method for searching a differentiated maturity inhibitor for fat cells, or a fat accumulation inhibitor being effective on systematic or local body fat reduction.SOLUTION: The method for searching a differentiated maturity inhibitor for fat cells and/or a fat accumulation inhibitor is characterized in evaluating a laminin signal inhibition activity by a test substance in the fat cell. The laminin signal inhibition activity may be an activity for inhibiting the bond of laminin and laminin receptor, the laminin signal inhibition activity may be an activity for inhibiting the expression of laminin and laminin receptor, or the laminin signal inhibition activity may be an activity for inhibiting intracellular signal transduction caused by the laminin.

    Abstract translation: 要解决的问题：提供一种用于搜索脂肪细胞的分化成熟抑制剂的方法，或对系统或局部体内脂肪减少有效的脂肪蓄积抑制剂。 解决方案：用于搜索脂肪细胞和/或脂肪蓄积抑制剂的分化成熟抑制剂的方法的特征在于通过脂肪细胞中的测试物质评价层粘连蛋白信号抑制活性。 层粘连蛋白信号抑制活性可以是抑制层粘连蛋白和层粘连蛋白受体结合的活性，层粘连蛋白信号抑制活性可以是抑制层粘连蛋白和层粘连蛋白受体表达的活性，或者层粘连蛋白信号抑制活性可以是抑制 由层粘连蛋白引起的细胞内信号转导。 版权所有（C）2013，JPO＆INPIT

    Prevention or improving agent for fructose-induced disease
    39.
    发明专利
    Prevention or improving agent for fructose-induced disease 审中-公开
    预防或改善溃疡性疾病的药物

    公开(公告)号：JP2012031135A

    公开(公告)日：2012-02-16

    申请号：JP2011099206

    申请日：2011-04-27

    Applicant: Kao Corp ,  花王株式会社

    Inventor： MORI TAKUYA ,  KONDO HIDEHIKO ,  MURASE TAKATOSHI

    IPC: A61K31/685 ,  A61K31/683 ,  A61K36/00 ,  A61K36/48 ,  A61P3/06 ,  A61P3/10 ,  A61P43/00 ,  C12N15/09 ,  C12Q1/68

    Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical drug or the like for prevention or improvement of diseases such as insulin resistance, fatty liver, and hyperlipemia induced by fructose ingestion, or to provide a material that can use for the pharmaceutical drug and food.SOLUTION: The preventing/improving agent for a fructose-induced disease contains a phospholipid as an active ingredient.

    Abstract translation: 要解决的问题：提供用于预防或改善由果糖摄取引起的胰岛素抵抗，脂肪肝和高脂血症等疾病的药物等，或提供可用于药物的材料和 餐饮。 解决方案：果糖诱导的疾病的预防/改善剂含有磷脂作为活性成分。 版权所有（C）2012，JPO＆INPIT

    Dgat inhibitor
    40.
    发明专利
    Dgat inhibitor 审中-公开
    DGAT抑制剂

    公开(公告)号：JP2011037720A

    公开(公告)日：2011-02-24

    申请号：JP2009183644

    申请日：2009-08-06

    Applicant: Kao Corp ,  花王株式会社

    Inventor： HASHIZUME KOJIRO ,  KONDO HIDEHIKO ,  MURASE TAKATOSHI

    IPC: A61K36/73 ,  A61K31/7024 ,  A61K36/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P5/50 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To provide a DGAT inhibitor and a TG synthesis-suppressing agent. SOLUTION: The DGAT inhibitor and the TG synthesis-suppressing agent comprise raspberry or an extract thereof as an effective ingredient. Preferably, the DGAT inhibitor comprises the extract extracted with an organic solvent. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供DGAT抑制剂和TG合成抑制剂。 解决方案：DGAT抑制剂和TG合成抑制剂包括覆盆子或其提取物作为有效成分。 优选地，DGAT抑制剂包含用有机溶剂萃取的提取物。 版权所有（C）2011，JPO＆INPIT

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