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    33.
    发明专利
    未知

    公开(公告)号：ES2068861T3

    公开(公告)日：1995-05-01

    申请号：ES89116195

    申请日：1989-09-01

    Applicant: KAO CORP

    Inventor： SATO HIROTAKA ,  YOROZU HIDENORI ,  ANDO MASATOMO ,  NISHIZAWA YOSHINORI

    IPC: A61K8/00 ,  A61K8/49 ,  A61K8/97 ,  A61Q19/10 ,  A61K7/48 ,  A61K7/50

    Abstract: A bathing preparation comprising an alkyl phthalide and/or an alkoxy phthalide and/or an alkylidene phthalide optionally together with carbon dioxide gas or a material capable of generating carbon dioxide gas and an extract of a plant belonging to the family Umbelliferae is disclosed. This bathing preparation has excellent effects of warming, retaining the warmth and accelerating blood circulation.

    34.
    发明专利
    未知

    公开(公告)号：DE68920381D1

    公开(公告)日：1995-02-16

    申请号：DE68920381

    申请日：1989-09-01

    Applicant: KAO CORP

    Inventor： SATO HIROTAKA ,  YOROZU HIDENORI ,  ANDO MASATOMO ,  NISHIZAWA YOSHINORI

    IPC: A61K8/00 ,  A61K8/49 ,  A61K8/97 ,  A61Q19/10 ,  A61K7/48 ,  A61K7/50

    Abstract: A bathing preparation comprising an alkyl phthalide and/or an alkoxy phthalide and/or an alkylidene phthalide optionally together with carbon dioxide gas or a material capable of generating carbon dioxide gas and an extract of a plant belonging to the family Umbelliferae is disclosed. This bathing preparation has excellent effects of warming, retaining the warmth and accelerating blood circulation.

    Fructosyl dipeptide or salt thereof
    37.
    发明专利
    Fructosyl dipeptide or salt thereof 有权
    果糖或其盐

    公开(公告)号：JP2010180240A

    公开(公告)日：2010-08-19

    申请号：JP2010095789

    申请日：2010-04-19

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SUGIYAMA MITSURU ,  SAKASAI MITSUYOSHI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI

    IPC: C07K5/062 ,  A61K8/64 ,  A61Q7/02 ,  A61Q19/08

    Abstract: PROBLEM TO BE SOLVED: To provide a skin care preparation for external use having efficacy for preventing or improving skin aging such as wrinkles and also having efficacy for inhibiting hair growth.
    SOLUTION: There are provided fructosyl dipeptide represented by general formula (1): Fru-A-B-R or its salt, as well as a skin care preparation for external use, a hair growth inhibitor and a wrinkle-preventing or improving agent, each containing the same. In the general formula (1), Fru represents a fructosyl residue; A represents a valine residue or an isoleucine residue; B represents a tyrosine residue, a phenylalanine residue, a valine residue or an isoleucine residue; R represents a hydroxy group or a methoxy group.
    COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种具有用于预防或改善皮肤老化如皱纹的功效的外用护肤品，并且还具有抑制头发生长的功效。 提供由通式（1）表示的果糖基二肽：Fru-ABR或其盐，以及外用护肤品，毛发生长抑制剂和防皱或改善剂，每种 含有相同的 在通式（1）中，Fru表示果糖基残基; A代表缬氨酸残基或异亮氨酸残基; B代表酪氨酸残基，苯丙氨酸残基，缬氨酸残基或异亮氨酸残基; R表示羟基或甲氧基。 版权所有（C）2010，JPO＆INPIT

    Method for producing branched fatty acid
    38.
    发明专利
    Method for producing branched fatty acid 有权
    生产分支脂肪酸的方法

    公开(公告)号：JP2009149546A

    公开(公告)日：2009-07-09

    申请号：JP2007327735

    申请日：2007-12-19

    Applicant: Kao Corp ,  花王株式会社

    Inventor： ISHITA MIO ,  FUJIMORI TAKETOSHI ,  NISHIZAWA YOSHINORI

    IPC: C07C51/353 ,  C07B61/00 ,  C07C53/126

    Abstract: PROBLEM TO BE SOLVED: To provide a simple and efficient method for producing a useful branched fatty acid using industrially available raw materials. SOLUTION: The method for producing a branched fatty acid comprises (a) causing a cyclic ester represented by formula (1) (in the formula, n represents an integer of 9 to 17) to react with hydrogen bromide in an acetic acid solvent to obtain a bromocarboxylic acid represented by formula (2): Br-(CH 2 ) n -CO 2 H (in the formula, n is the same as defined above) and (b) subsequently causing the resulting bromocarboxylic acid to react with a Grignard reagent represented by formula (3): R 1 MgX (in the formula, R 1 represents a 3-8C branched alkyl group, and X represents a halogen atom) to obtain a 13-26C branched fatty acid represented by formula (4): R 1 -(CH 2 ) n -CO 2 H (in the formula, R 1 is the same as defined above, and n is the same as defined above). COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 待解决的问题：提供使用工业上可获得的原料制备有用的支链脂肪酸的简单有效的方法。 解决方案：支链脂肪酸的制备方法包括：（a）使式（1）表示的环状酯（式中，n表示9〜17的整数）与溴化氢在乙酸中反应 溶剂以得到由式（2）表示的溴代羧酸：Br-（CH 2 SB 2）SB（H 2）（式中， n与上述定义相同）和（b）随后使得到的溴羧酸与由式（3）表示的格利雅试剂反应：式中，R 1 表示3-8C支链烷基，X表示卤素原子），得到由式（4）表示的13-26C支链脂肪酸：R - （CH < （式中，R 1 ）H（在式中，R SP 1与上述定义相同，n 与上述相同）。 版权所有（C）2009，JPO＆INPIT

    Method for producing cross-coupled compound
    40.
    发明专利
    Method for producing cross-coupled compound 有权
    生产交联偶联体的方法

    公开(公告)号：JP2008255050A

    公开(公告)日：2008-10-23

    申请号：JP2007098663

    申请日：2007-04-04

    Applicant: Kao Corp ,  花王株式会社

    Inventor： FUJIMORI TAKETOSHI ,  ISHITA MIO ,  NISHIZAWA YOSHINORI

    IPC: C07C51/353 ,  B01J27/122 ,  C07B61/00 ,  C07C53/126

    CPC classification number: Y02P20/52

    Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a cross-coupled compound. SOLUTION: The method for producing the cross-coupled compound comprises conducting a reaction between a Grignard compound and an organic electrophilic agent in the presence of a copper catalyst and a phosphine of formula R 3 3 P (wherein, R 3 is a 1-6C alkyl, cyclohexyl or a phenyl group optionally having a methyl or methoxy group) or a phosphite of the formula (R 4 O) 3 P (wherein, R 4 is a 1-4C alkyl). COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 待解决的问题：提供交联化合物的制造方法。 解决方案：交联偶联化合物的制备方法包括在铜催化剂和式R 3 SP的存在下，在格氏化合物和有机亲电子试剂之间进行反应 >其中R 3为具有甲基或甲氧基的1-6C烷基，环己基或苯基）或式（R 4（其中，R SP 4是一个1-4C烷基）。 版权所有（C）2009，JPO＆INPIT

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