公开(公告)号：EP1877000A4

公开(公告)日：2010-07-14

申请号：EP06748605

申请日：2006-03-23

Applicant: MAYO FOUNDATION

Inventor： DADSETAN MAHROKH ,  YASZEMSKI MICHAEL ,  LU LICHUN

IPC: A61F2/00 ,  A61K31/79 ,  C08F283/06 ,  C08F289/00 ,  C08F290/00 ,  C08F290/06 ,  C08F290/14 ,  C08J3/24 ,  C08J3/28 ,  C08L51/08

CPC classification number: A61K31/79 ,  A61L27/18 ,  A61L27/3817 ,  A61L27/3821 ,  B33Y70/00 ,  B33Y80/00 ,  C08F283/01 ,  C08F283/06 ,  C08L71/02 ,  C08F2/48 ,  C08F226/10

公开(公告)号：EP1651708A4

公开(公告)日：2008-10-22

申请号：EP04777241

申请日：2004-06-29

Applicant: MAYO FOUNDATION

Inventor： YASZEMSKI MICHAEL J ,  CURRIER BRADFORF L ,  JABBARI ESMAIEL ,  LU LICHUN

IPC: C08J5/12 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61L27/42

CPC classification number: C08F292/00 ,  A61F2/28 ,  A61F2002/30062 ,  A61F2210/0004 ,  A61F2310/00293 ,  A61L27/425

Abstract: A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.

公开(公告)号：EP1646670A4

公开(公告)日：2008-04-16

申请号：EP04777316

申请日：2004-06-29

Applicant: MAYO FOUNDATION

Inventor： YASZEMSKI MICHAEL J ,  CURRIER BRADFORD L ,  JABBARI ESMAIEL ,  LU LICHUN

IPC: C08G63/08 ,  A61K20060101 ,  A61L24/04 ,  A61L26/00 ,  C08F290/00 ,  C08G63/91 ,  C08J9/26 ,  C08L67/04

CPC classification number: C08G63/08 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0084 ,  A61L24/046 ,  A61L27/18 ,  A61L27/46 ,  A61L27/56 ,  A61L27/58 ,  A61L2430/02 ,  C08F290/00 ,  C08G63/60 ,  C08G63/912 ,  C08J9/26 ,  C08J2367/04 ,  C08K3/32 ,  C08L67/06 ,  C08L67/04

Abstract: Fumaric acid or a salt thereof, such as a fumaryl halide (e.g., fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with a biodegradable poly(caprolactone) macromer that has a flexible backbone such that the resulting copolymer may self-crosslink in the absence of a crosslinking agent. The biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction.

公开(公告)号：EP1812481A4

公开(公告)日：2010-07-21

申请号：EP05851973

申请日：2005-11-18

Applicant: MAYO FOUNDATION

Inventor： WANG SHANGFENG ,  YASZEMSKI MICHAEL J ,  LU LICHUN ,  CURRIER BRADFORD L

IPC: C08F20/00 ,  A61F2/00 ,  A61L27/42 ,  B32B27/00 ,  C08G63/02 ,  C08G63/08 ,  C08G81/00 ,  C08J9/26 ,  C08K5/00

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/46 ,  B33Y70/00 ,  B33Y80/00 ,  C08G63/08 ,  C08G63/60 ,  C08G2261/126 ,  C08J9/26 ,  C08J2201/024 ,  C08J2201/0446 ,  C08J2367/06 ,  C08L67/06

公开(公告)号：EP1664168A4

公开(公告)日：2006-09-13

申请号：EP04782412

申请日：2004-08-27

Applicant: MAYO FOUNDATION

Inventor： JABBARI ESMAIEL ,  YASZEMSKI MICHAEL J ,  CURRIER BRADFORD L ,  LU LICHUN

IPC: C08J9/00 ,  A61F20060101 ,  A61L27/48 ,  A61L27/56 ,  A61L27/58 ,  C08K5/00

CPC classification number: A61L27/56 ,  A61L27/48 ,  A61L27/58