公开(公告)号：EP3704109A1

公开(公告)日：2020-09-09

申请号：EP18795409.4

申请日：2018-10-23

Applicant: Procos S.p.A.

Inventor： MORANA, Fabio ,  GOBBATO, Stefano ,  COZZI, Lucia ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07D403/06 ,  A61K31/506 ,  A61P35/00

公开(公告)号：EP2658839B1

公开(公告)日：2014-10-22

申请号：EP11817220.4

申请日：2011-12-28

Applicant: Procos S.p.A.

Inventor： BAROZZA, Alessandro ,  COLOMBO, Matteo ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：EP2658839A1

公开(公告)日：2013-11-06

申请号：EP11817220.4

申请日：2011-12-28

Applicant: Procos S.p.A.

Inventor： BAROZZA, Alessandro ,  COLOMBO, Matteo ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: Disclosed is a process for the synthesis of Nicorandil (1), 2-(nicotinamide)ethyl nitrate, starting from N-(2-hydroxyethyl)nicotinamide (15), using nitration with nitric acid in the presence of acetic anhydride Said synthesis method is particularly advantageous because it solves the safety problems involved in the use of nitric acid as nitrating agent, and allows a product with excellent yields and quality to be isolated.