公开(公告)号：WO2012089769A1

公开(公告)日：2012-07-05

申请号：PCT/EP2011/074152

申请日：2011-12-28

Applicant: PROCOS S.P.A. ,  BAROZZA, Alessandro ,  COLOMBO, Matteo ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

Inventor： BAROZZA, Alessandro ,  COLOMBO, Matteo ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: Disclosed is a process for the synthesis of Nicorandil (1), 2-(nicotinamide)ethyl nitrate, starting from N-(2-hydroxyethyl)nicotinamide (15), using nitration with nitric acid in the presence of acetic anhydride Said synthesis method is particularly advantageous because it solves the safety problems involved in the use of nitric acid as nitrating agent, and allows a product with excellent yields and quality to be isolated.

Abstract translation: 公开了一种从N-（2-羟乙基）烟酰胺（15）开始合成尼可地尔（1），2-（烟酰胺）乙酸乙酯的方法，使用硝酸在乙酸酐存在下硝化所述合成方法为 特别有利，因为它解决了使用硝酸作为硝化剂所涉及的安全问题，并且能够分离出优异的产率和质量的产品。

公开(公告)号：EP2658839B1

公开(公告)日：2014-10-22

申请号：EP11817220.4

申请日：2011-12-28

Applicant: Procos S.p.A.

Inventor： BAROZZA, Alessandro ,  COLOMBO, Matteo ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

公开(公告)号：EP2658839A1

公开(公告)日：2013-11-06

申请号：EP11817220.4

申请日：2011-12-28

Applicant: Procos S.p.A.

Inventor： BAROZZA, Alessandro ,  COLOMBO, Matteo ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07C201/02

CPC classification number: C07C201/02 ,  C07C203/04

Abstract: Disclosed is a process for the synthesis of Nicorandil (1), 2-(nicotinamide)ethyl nitrate, starting from N-(2-hydroxyethyl)nicotinamide (15), using nitration with nitric acid in the presence of acetic anhydride Said synthesis method is particularly advantageous because it solves the safety problems involved in the use of nitric acid as nitrating agent, and allows a product with excellent yields and quality to be isolated.