公开(公告)号：WO2013109706A1

公开(公告)日：2013-07-25

申请号：PCT/US2013/021865

申请日：2013-01-17

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: A61M5/48

CPC classification number: A61M5/31593 ,  A61J7/0053 ,  A61M5/1782 ,  A61M5/204 ,  A61M2005/3126 ,  A61M2005/3128 ,  B05B9/0426 ,  B05B11/0048 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3015 ,  B05B11/3028 ,  B05B11/3064 ,  B05B11/3077 ,  B65D83/7535 ,  G01F11/02 ,  G01F11/025 ,  G01F11/027 ,  G01F11/028

Abstract: A multiple dose syringe has a first valve defining a first valve opening pressure and a second valve defining a second valve opening pressure. A storage chamber in fluid communication with the second valve stores multiple doses of a substance therein and includes an outlet for dispensing multiple doses of the stored substance therethrough. A compression surface is movable between first and second positions and defines a compression chamber between the compression surface and the first valve. Movement of the compression surface in a direction from the first position toward the second position dispenses substance in the compression chamber through the first valve and out of the syringe. Movement of the compression surface in a direction from the second position toward the first position causes substance to flow from the storage chamber through the second valve and into the compression chamber.

Abstract translation: 多剂量注射器具有限定第一阀开启压力的第一阀和限定第二阀开启压力的第二阀。 与第二阀流体连通的储存室在其中存储多个剂量的物质，并且包括用于通过其分配多个剂量的储存物质的出口。 压缩表面可在第一和第二位置之间移动，并且在压缩表面和第一阀之间限定压缩室。 压缩表面在从第一位置朝向第二位置的方向上的运动通过第一阀和注射器分配压缩室中的物质。 压缩表面在从第二位置朝向第一位置的方向上的移动使得物质从存储室通过第二阀流入压缩室。

公开(公告)号：WO2009052521A1

公开(公告)日：2009-04-23

申请号：PCT/US2008/080551

申请日：2008-10-20

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: B65D53/00

CPC classification number: B65D41/0492 ,  B65D41/20 ,  B65D51/18 ,  B65D2251/0015 ,  B65D2251/0078

Abstract: A container comprising a container body defining a storage chamber for receiving a substance and a container closure removably attached to the container body for sealing the storage chamber. The container closure includes a base defining an aperture in fluid communication with the storage chamber, and a needle penetrable and thermally resealable stopper overlying the aperture for aseptically filling the storage chamber with the substance and sealing the substance within the storage chamber with respect to the ambient atmosphere. A sealing portion engages the container body prior to filling and forms a substantially dry hermetic seal between the container closure and container body. The container further comprises an over closure engageable with the container closure such that removal or movement of the over closure from a first position to a second position results in substantially simultaneous removal of the container closure and stopper to allow dispensing of the substance.

Abstract translation: 一种容器，其包括限定用于容纳物质的储存室的容器主体和可拆卸地附接到容器主体以密封存储室的容器封闭件。 容器封闭件包括限定与存储室流体连通的孔的基座和覆盖孔的针穿透和可热再密封的塞子，用于将物质无菌地填充储存室并相对于环境将物质密封在储存室内 大气层。 密封部分在填充之前与容器本体接合，并在容器封闭件和容器主体之间形成基本上干燥的密封。 容器还包括可与容器封闭件接合的过盖，使得将封闭件从第一位置移除或移动到第二位置导致基本上同时移除容器封闭件和止动件以允许物质分配。

公开(公告)号：WO2005086677A2

公开(公告)日：2005-09-22

申请号：PCT/US2005/007028

申请日：2005-03-03

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: B65B1/04 ,  B67C3/00

CPC classification number: B65B7/161 ,  B65B3/003 ,  B65B7/00 ,  B65B37/06 ,  B65B43/54 ,  B65B51/22 ,  B65B55/04 ,  B65B55/08 ,  B65B57/00 ,  B65B65/02

Abstract: An apparatus is provided for needle filling and thermally resealing containers having stoppers that are needle penetrable for filling the containers with a substance, and are thermally resealable for thermally sealing a needle hole in the stopper upon withdrawal of a needle therefrom. A container support of the apparatus supports at least one container having a resealable stopper in a substantially fixed position during needle filling and thermally resealing a needle hole in the stopper upon withdrawal of a needle therefrom. A robotic arm of the apparatus is drivingly mounted adjacent to the container support and movable relative thereto. A manifold is drivingly mounted on the robotic arm and includes (1) a needle for penetrating the resealable stopper and introducing a substance through the needle and into the container; (2) a laser optic assembly for heating a needle penetrated region of the stopper and, in turn, sealing a needle hole in the stopper; and (3) a temperature sensor for sensing the temperate of a needle penetrated region of the stopper to determine whether a needle hole therein is sealed. The manifold is movable laterally relative to the container on the container support to position the manifold relative to a needle penetrable region of the stopper of the container.

Abstract translation: 提供了一种用于针头填充和热重新密封容器的装置，其具有用于针对物品填充容器的可穿刺的塞子，并且在从其中取出针时，可热再密封用于热封塞塞中的针孔。 装置的容器支撑件支撑至少一个具有可重新封闭的塞子的容器，该容器在针填充期间处于基本上固定的位置，并且在从其中取出针时将塞子中的针孔热再密封。 装置的机器臂相对于容器支架驱动地安装并相对于其移动。 歧管被驱动地安装在机器臂上，并且包括（1）用于穿透可再密封止动件的针并将物质通过针引入容器中; （2）激光光学组件，用于加热塞子的针穿透区域，并进而密封塞子中的针孔; 以及（3）温度传感器，用于检测塞子的针穿透区域的温度，以确定其中的针孔是否被密封。 歧管相对于容器支架上的容器横向移动，以使歧管相对于容器的塞子的针可穿透区域定位。

公开(公告)号：WO2005050287A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/038305

申请日：2004-11-17

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: G02C

CPC classification number: A61F9/0061 ,  A45C11/005

Abstract: A contact lens transfer device for transferring a contact lens from a storage container to a contact lens applicator has a body and a contact lens holder movably mounted on the body. The contact lens holder defines a contact lens support surface, a fluid-flow aperture extending through the contact lens support surface, and a chamber coupled in fluid communication with the fluid-flow aperture. A contact lens is removably receivable on the lens support surface, and the fluid-flow aperture is coupled in fluid communication with an interface between the contact lens and lens support surface for introducing fluid from the chamber, through the fluid-flow aperture and into the interface to release the lens from the lens support surface.

Abstract translation: 用于将隐形眼镜从存储容器转移到隐形眼镜施加器的隐形眼镜转移装置具有可移动地安装在身体上的身体和隐形眼镜保持器。 隐形眼镜保持器限定隐形眼镜支撑表面，延伸穿过隐形眼镜支撑表面的流体流动孔，以及与流体流动孔流体连通的腔室。 隐形眼镜可移除地容纳在透镜支撑表面上，并且流体流动孔与隐形眼镜和透镜支撑表面之间的界面流体连通地联接，用于将来自腔室的流体引导通过流体流动孔并进入 界面以从透镜支撑表面释放透镜。

公开(公告)号：WO2005048875A2

公开(公告)日：2005-06-02

申请号：PCT/US2004/038345

申请日：2004-11-15

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  CHAN, Julian, V. ,  ATWOOD, Jeffrey, M.

Inventor： PY, Daniel ,  CHAN, Julian, V. ,  ATWOOD, Jeffrey, M.

IPC: A61F

CPC classification number: B05B11/007 ,  A61F9/0008 ,  A61M11/007 ,  A61M15/08 ,  A61M35/003 ,  A61M2210/0612 ,  B05B11/0043 ,  B05B11/0048 ,  B05B11/0056 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3056 ,  B05B11/307 ,  B05B11/3074 ,  B05B11/3077

Abstract: An ophthalmic delivery device includes a body defining a fluid reservoir and a pump in fluid communication with the reservoir. The delivery device also includes a nozzle that includes a dosage chamber for holding a dosage of fluid, a valve seat, and a valve cover. The valve cover extends about the valve seat and forms an interface therebetween and the valve seat includes an outlet aperture. The interface is in fluid communication with the outlet aperture and the dosage chamber, and at least part of the valve cover is movable between (i) a closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The valve seat and the valve cover are dimensioned to dispense the dosage of fluid through the interface at a velocity of equal to or less than 6 meters per second.

Abstract translation: 眼科输送装置包括限定流体储存器的主体和与储存器流体连通的泵。 输送装置还包括喷嘴，该喷嘴包括用于保持一定量的流体的剂量室，阀座和阀盖。 阀盖围绕阀座延伸并且在它们之间形成界面，并且阀座包括出口孔。 所述界面与所述出口孔和所述剂量室流体连通，并且所述阀盖的至少一部分可在（i）与所述阀盖接合所述阀座的关闭位置之间移动以关闭所述界面并形成流体密封 密封在其间，和（ii）打开位置，其中阀盖的至少一部分响应于流体以大于阀打开压力的压力流过出口孔而与阀座间隔开，以允许加压流体在其间通过 。 阀座和阀盖的尺寸设计为以等于或小于6米/秒的速度通过界面分配流体的剂量。

公开(公告)号：WO2004014778A2

公开(公告)日：2004-02-19

申请号：PCT/US2003/025487

申请日：2003-08-13

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel ,  CHAN, Julian ,  ASSION, Norbert, M.

Inventor： PY, Daniel ,  CHAN, Julian ,  ASSION, Norbert, M.

IPC: B67C

CPC classification number: B65D47/205 ,  A45D40/26 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D83/0055

Abstract: A container including a nozzle and body depending therefrom. The body is preferably tubular and defines an interior which retains a product to be dispensed. A cap engages the nozzle to prevent inadvertent release of the product. In order to dispense the product, the cap is removed and pressure is applied to the body and the nozzle allows release of the product. The nozzle releases the product without exposing the remaining product to the external atmosphere, thus the sterility of the interior of the body is maintained and the shelf life of the product is increased. The nozzle includes an inner body, coupled to the tubular body, surrounded by a flexible outer cover. A seam between the inner body and flexible outer cover forms a one-way release valve wherein a portion of the seam remains closed during dispensing the product.

Abstract translation: 一种容器，其包括从其排出的喷嘴和主体。 主体优选地是管状的并且限定保持要分配的产品的内部。 盖子与喷嘴接合以防止产品的意外释放。 为了分配产品，盖被去除并且压力施加到主体上，并且喷嘴允许释放产品。 喷嘴释放产品而不将剩余的产品暴露于外部大气，从而维持身体内部的不整洁性并且提高了产品的保质期。 该喷嘴包括一个连接到管状主体的内部主体，被一个柔性的外盖包围。 内体和柔性外盖之间的接缝形成单向释放阀，其中在分配产品期间，接缝的一部分保持关闭。

公开(公告)号：WO2004004803A2

公开(公告)日：2004-01-15

申请号：PCT/US2003/021546

申请日：2003-07-08

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61M

CPC classification number: A61M5/425 ,  A61M5/2033 ,  A61M5/24 ,  A61M5/326 ,  A61M5/3287

Abstract: A device for intradermal delivery having a housing containing a syringe for injecting a substance at a predetermined insertion depth and a base assembly for tensioning a target area of skin. One embodiment tensions the skin by vacuum and another by expansion of a mounting surface in contact with the skin. Upon tensioning the target area, a needle extends into the target area to the insertion depth. At the insertion depth, a plunger depresses within the syringe and delivers the substance therein through the needle. Upon completing injection, the needle retracts, the skin tensioning is released and the intradermal delivery device is removed.

Abstract translation: 一种用于皮内递送的装置，其具有包含用于在预定插入深度注射物质的注射器的壳体和用于张紧皮肤目标区域的基座组件。 一个实施方案是通过真空而使皮肤张紧，另一个实施例通过与皮肤接触的安装表面的膨胀来张紧皮肤。 在张紧目标区域时，针延伸到目标区域到插入深度。 在插入深度时，柱塞在注射器内压下并通过针将物质输送到其中。 完成注射后，针头缩回，释放皮肤张力并移除皮内递送装置。

公开(公告)号：WO2003028785A3

公开(公告)日：2003-04-10

申请号：PCT/US2002/031834

申请日：2002-10-03

Applicant: MEDICAL INSTILL TECHNOLOGIES, INC. ,  PY, Daniel

Inventor： PY, Daniel

IPC: A61M5/00

Abstract: A syringe and a reconstitution (210) syringe are provided for the delivery of controlled doses of any different sterile substances, such as vaccines, medicaments, cosmetics, and food products. A plunger (214) of the syringe defines a resealable stopper (216) frictionally and slidably received within a hollow syringe body (212) for dispensing the medicament through a dispensing tip (217) of the syringe upon movement of the plunger. The resealable stopper (216) defines a heat-sealable portion to allow the stopper to be penetrated by a needle or other filling device to fill the syringe with a medicament, and in turn allow the hole remaining upon withdrawal of the needle to be heat sealed by transmission of laser energy thereon. The plunger assembly further defines a plurality of cam-like members (264) that each engage and cooperate with a respective helical path of steps formed on the inner wall of the syringe body to provide stepwise movement of the plunger and, in turn, precise metering of the substance dispensed therefrom. A reconstitution syringe defines within a syringe body plural compartments, (298,300), wherein each compartment stores a respective component of a multi-component medicament or other substances. An elastomeric plug (272) is coupled to the plunger and connected between the two compartments to prevent intermixing of the components.

公开(公告)号：WO1995009669A1

公开(公告)日：1995-04-13

申请号：PCT/US1994010890

申请日：1994-09-27

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: A61M35/00

CPC classification number: A61F9/0026 ,  A61F9/0008 ,  A61F2250/0067

Abstract: This invention is a cartridge (10) for actuating a piston-like or accordion-like dispenser vial for applying medicament to an eye. The cartridge (10) includes a housing for holding the dispenser vial and a telescoping cylinder (18) for compressing the dispenser vial in the longitudinal direction to actuate the vial. The cartridge includes a locking mechanism (43) for locking the telescoping cylinder (18) to restrict its movement and a lever mechanism for releasing the cylinder from the locked position so that a drop is released from the dispenser. The housing includes a finger (57) for engaging the lower eyelid and exposing the conjunctival cul-de-sac.

Abstract translation: 本发明是用于致动用于向眼睛施用药物的活塞式或类风琴式分配器小瓶的盒（10）。 盒（10）包括用于保持分配器小瓶的壳体和用于在纵向方向上压缩分配器小瓶以致动小瓶的伸缩筒（18）。 该卡盘包括用于锁定伸缩式汽缸（18）以限制其运动的锁定机构（43）和用于将汽缸从锁定位置释放的杠杆机构，使得液滴从分配器释放。 壳体包括用于接合下眼睑并暴露结膜切口的手指（57）。

公开(公告)号：WO2017127566A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014168

申请日：2017-01-19

Applicant: PY, Daniel

Inventor： PY, Daniel

IPC: B05B7/10 ,  B05B1/34 ,  B05B7/00 ,  B05B7/02 ,  B05B7/04 ,  B05B11/00

CPC classification number: B01F5/0062 ,  B01F3/0861 ,  B01F3/20 ,  B01F5/0057 ,  B01F15/00071 ,  B01F15/0245 ,  B01F2215/0014 ,  B01F2215/0022 ,  B01F2215/0031 ,  B01F2215/0032

Abstract: An outer shell and nozzle portion define therebetween a swirl chamber having a plurality of inlet flow paths and an outlet flow path. The swirl chamber may receive a plurality of substances or components from separate sources, to mix the plurality of substances in the swirl chamber, and to deliver the mixed substances or formulation through an outlet, e.g., to a connector. The substances may be sterile, and the entire flow path from the substance sources to the container may be sterile and aseptically sealed from ambient atmosphere. The outer shell and nozzle portion may be constructed of plastic or other disposable materials. The swirl chamber may be constructed to optimize the mixing of the substances through control of the velocity by which each substance enters the swirl chamber.

Abstract translation: 外壳和喷嘴部分在它们之间限定具有多个入口流动路径和出口流动路径的涡流室。 涡流室可接收来自不同来源的多种物质或组分，以在涡流室中混合多种物质，并将混合物质或制剂通过出口输送至例如连接器。 这些物质可以是无菌的，并且从物质源到容器的整个流动路径可以是无菌的并且与环境大气无菌密封。 外壳和喷嘴部分可以由塑料或其他一次性材料构成。 涡流室可以被构造成通过控制每种物质进入涡流室的速度来优化物质的混合。