中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

68 records (took 0.034 seconds)

    BIOCHEMICAL PRODUCTION OF (S)-1-ETHYNYL-2-METHYL-2-PENTENOL
    31.
    发明专利
    BIOCHEMICAL PRODUCTION OF (S)-1-ETHYNYL-2-METHYL-2-PENTENOL 失效

    公开(公告)号：JPH03210192A

    公开(公告)日：1991-09-13

    申请号：JP749990

    申请日：1990-01-16

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： MITSUTA MASARU ,  NABESHIMA NARIYASU

    IPC: C12P41/00

    Abstract: PURPOSE:To industrially and advantageously produce (S)-1-ethynyl-2-methyl-2- pentenol by stereoselectively esterifying the corresponding racemic modification in the presence of a lipase and optically resolving the resultant esters. CONSTITUTION:A lipase produced by a microorganism belonging to the genus Pseudomonas or Alcaligenes is added to a mixture solution of 1-ethynyl-2- methyl-2-pentenol which is a racemic modification, vinyl ester, isopropyl ester or anhydride of a lower fatty acid and the resultant mixture is stirred at about 20-100 deg.C for about 3-120hr to afford a lower fatty acid ester of (R)-1-ethynyl-2- methyl-2-pentenol and (S)-1-ethynyl-2-methyl-2-pentenol. Both the products are then separated and recovered.

    PRODUCTION OF OPTICALLY ACTIVE HYDROXYCYCLOPENTENONES
    34.
    发明专利
    PRODUCTION OF OPTICALLY ACTIVE HYDROXYCYCLOPENTENONES 失效

    公开(公告)号：JPS63254995A

    公开(公告)日：1988-10-21

    申请号：JP29852687

    申请日：1987-11-25

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： MINAMII MASAYOSHI ,  AZUMAI TAKAYUKI ,  UEDA YUJI ,  KONDO TOMOMASA ,  ANDO YASUMITSU ,  MITSUTA MASARU

    IPC: C12P41/00 ,  C07C45/00 ,  C07C49/707 ,  C07C67/00 ,  C07F7/18

    Abstract: PURPOSE:To readily obtain the titled compound useful as an intermediate for prostaglandin derivatives which are medicines in good yield, by reacting dl- cyclopentenone esters having a specific structural formula with esterase and carrying out asymmetric hydrolysis. CONSTITUTION:dl-Cyclopentenone esters expressed by formula I (R1 is alkyl; R' is hydroxyl group-protecting group; n is 4-8) are reacted with esterase and asymmetrically hydrolyzed to afford the aimed optically active hydroxycyclopentenones expressed by formula II (R is H or hydroxyl group- protecting group; mark * indicates asymmetric carbon). Furthermore, the above- mentioned hydrolysis is normally carried out by vigorously stirring in a buffer solution at 10-60 deg.C for 3-70hr.

    BIOCHEMICAL PRODUCTION OF OPTICALLY ACTIVE 4-HYDROXY-2-CYCLOPENTENONE
    36.
    发明专利
    BIOCHEMICAL PRODUCTION OF OPTICALLY ACTIVE 4-HYDROXY-2-CYCLOPENTENONE 失效

    公开(公告)号：JPS62244394A

    公开(公告)日：1987-10-24

    申请号：JP8886986

    申请日：1986-04-17

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： MITSUTA MASARU ,  ANDO YASUMITSU ,  KISHIMOTO FUMITAKA

    IPC: C12P41/00 ,  C12R1/01 ,  C12R1/025 ,  C12R1/05 ,  C12R1/06 ,  C12R1/38 ,  C12R1/72

    Abstract: PURPOSE:To obtain the titled cyclopentenone useful for antiulcer action, thrombolytic action, etc., at a low cost in simple equipment, by reacting an ester of a specific compound with an esterase derived from a microorganism of the genus Achromobacter, etc. CONSTITUTION:A microorganism, e.g. the genus Achromobacter or Candida, capable of asymmetrically hydrolyzing an organic carboxylic acid ester of a racemic 4-hydroxy-2-cyclopentenone expressed by the formula (R is 1-18C alkyl, 2-18C alkenyl or 2-18C alkenyl) and producing optically active 4- hydroxy-2-cyclopentenone is cultivated to give a culture. The resultant culture, etc., is then added to a 0.1-5wt% solution of the above-mentioned racemic cyclopentenone ester to carry out asymmetric hydrolysis reaction at 10-70 deg.C and 6-10 pH within 10hr and the reaction solution is then subjected to treatment, e.g. fractional distillation, etc., to separate and recover the aimed optically active 4-hydroxy-2-cyclopentenone.

    STEREOSELECTIVE HYDROLYSIS OF CYANOHYDRIN DERIVATIVE
    37.
    发明专利
    STEREOSELECTIVE HYDROLYSIS OF CYANOHYDRIN DERIVATIVE 失效

    公开(公告)号：JPS6265688A

    公开(公告)日：1987-03-24

    申请号：JP20724185

    申请日：1985-09-18

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： MATSUO NORITADA ,  MITSUTA MASARU

    IPC: C12P41/00 ,  C12P7/62 ,  C12R1/38

    Abstract: PURPOSE:To obtain an optically active cyanohydrin compound and cyanohydrin ester, easily, by reacting a specific cyanohydrin derivative with an esterase under neutral or acidic condition and subjecting the reaction product to asymmetric hydrolysis. CONSTITUTION:The optically active cyanohydrin compound of formula II and an optically active cyanohydrin ester of formula II which is an antipode ester of the compound of formula II can be produced by (1) reacting (A) the cyanohydrin derivative of formula I [R1 is H, 1-18C alkyl, 2-18C alkenyl, etc.; R2 is 1-18C alkyl, aryl(substituted) 2-18C alkenyl, etc.) with (B) an esterase capable of asymmetrically hydrolyzing the cyanohydrin derivative and originated from microorganism belonging to Arthrobacter genus, Alcaligenes genus, etc., at

    FIXED LACTASE AND ITS PREPARATION
    39.
    发明专利
    FIXED LACTASE AND ITS PREPARATION 失效

    公开(公告)号：JPS5651984A

    公开(公告)日：1981-05-09

    申请号：JP12775479

    申请日：1979-10-02

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： HIROHARA HIDEO ,  YAMAMOTO HIDEFUMI ,  KOUNO EMIKO ,  NABESHIMA NARIYASU ,  MITSUTA MASARU ,  NAGASE TSUNEYUKI

    IPC: A23C9/12 ,  A23C21/02 ,  C12N9/38 ,  C12N11/06 ,  C12N11/08

    Abstract: PURPOSE:To prepare stable and water-insoluble lactase having high hydrolyzing ability of lactose, by fixing lactase derived from Aspergillus oryzae on an ampholytic ion exchange resin of phenol formaldehyde of microporous type. CONSTITUTION:Lactase derived from Aspergillus oryzae is adsorbed on an amphoytic ion exchange resin of phenol formaldehyde of microporous type having a specific surface not less than 1m /g, total pore volume of micropores with pore diameters 100-2,000Angstrom not less than 0.1cc/g, an anion exchange capacity based on amino or substituted amino group not less than 1meg/g and a cation exchange capacity based on carboxymethyl group not less than 0.5meg/g as a carrier in an aqueous solution in pH 4.0-6.5, the fixed lactase is treated with an aqueous solution of glutaraldehyde in pH 3.5-7.0, or glutaraldehyde is linked to the carrier and reacted with lactase.

    METHOD OF PREPARING HIGHHPURITY GLUCOISOMERASE
    40.
    发明专利
    METHOD OF PREPARING HIGHHPURITY GLUCOISOMERASE 失效

    公开(公告)号：JPS5581588A

    公开(公告)日：1980-06-19

    申请号：JP15512178

    申请日：1978-12-12

    Applicant: SUMITOMO CHEMICAL CO

    Inventor： NABESHIMA NARIYASU ,  HIROHARA HIDEO ,  MITSUTA MASARU ,  NAGASE TSUNEYUKI

    IPC: C12N9/92 ,  C12R1/465

    Abstract: PURPOSE:Glucoisomerase exctract from cells of microorganisms is partitioned with acetone under relatively high protein concentration, thus preparing simply high- purity glucoisomerase in high yield. CONSTITUTION:A glucoisomerase extract obtained from the bacterium cells containing it by a usual method is controlled to more than 10mg/l, preferably 10- 50mg/l protein concentration and to 6.0-8.0, preferably 6.4-7.6pH. Acetone is added to the controlled extract under stirring to recover the precipitate depositing while the acetone concentration is 40-75(v/v)%.

Patent Agency Ranking