公开(公告)号：AU2371677A

公开(公告)日：1978-10-05

申请号：AU2371677

申请日：1977-03-29

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MIYASHITA OSAMU ,  MATSUMURA KOICHI ,  SHIMADZU HIROSHI ,  HASHIMOTO NAOTO

IPC: A61K31/513 ,  A61P35/00 ,  C07C273/18 ,  C07C275/20 ,  C07C275/50 ,  C07D239/22 ,  C07D239/54 ,  C07D239/553 ,  C07D239/557 ,  C07D405/04 ,  C07F7/18 ,  A61K31/505 ,  A61K31/535 ,  C07D239/46 ,  C07D239/48 ,  C07D239/56 ,  C07D239/60 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14

公开(公告)号：ES2058057T3

公开(公告)日：1994-11-01

申请号：ES86116752

申请日：1986-12-02

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  HASHIMOTO NAOTO

IPC: A61K31/365 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P31/00 ,  C07D311/00 ,  C07D313/00 ,  C07D493/08 ,  C07H15/00

公开(公告)号：CA2109762A1

公开(公告)日：1994-05-25

申请号：CA2109762

申请日：1993-11-23

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： SASAKI SATOSHI ,  HATA YOSHIO ,  SHIBATA SACHIO ,  HASHIMOTO NAOTO

IPC: A01N25/10 ,  A01N47/12 ,  A01N47/28 ,  C07C271/20 ,  C07C275/14 ,  C07C333/04 ,  C07D213/38 ,  C07D213/40 ,  C08F20/34 ,  C08F20/36 ,  C08F290/00 ,  C08F299/02 ,  C07D215/14 ,  C07D217/16 ,  C07D211/34 ,  C07C323/43 ,  C07D213/56

Abstract: ANTIBACTERIAL, ANTIFUNGAL COMPOUND AND ITS PRODUCTION METHOD A compound represented by the following formula: (I) wherein R is an acyl group which may or not be substituted. R1 is a hydrogen atom, C1-10 hydrocarbon group which may or may not be substituted, or an acyl group which may or may not be substituted, R2 is a straight chain or branched C1-12 alkylene group which may or may not be substituted, A is a straight chain or branched C1-10 alkylene group, B is O, NH or S, Q is a tertiary amino or quaternary ammonium group, a nitrogen-containing heterocyclic group which may or may not be substituted, or a nitrogen-containing heterocyclic ammonium group which may or may not be substituted, and n is an integer from 1 to 10, and the method of manufacturing this compound.

公开(公告)号：CA1317962C

公开(公告)日：1993-05-18

申请号：CA573258

申请日：1988-07-28

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HASHIMOTO NAOTO ,  KATO KANEYOSHI ,  KOZAI YOSHIO

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/38 ,  C07C259/00 ,  C07D213/56 ,  C07D213/61 ,  C07D213/63 ,  C07D215/12 ,  C07D215/18 ,  C07D333/24 ,  C07C50/38

Abstract: of the disclosure A compound of the formula: (I) wherein, R1 and R2 are the same or different, representing methyl or methoxy groups, or form -CH=CH-CH=CH- by binding to each other; R3 is an aromatic group or a heterocyclic group which may be substituted; and n is an integer of 2 to 8, shows inhibitory effect of cell proliferation and is useful as cell proliferation inhibitor.

公开(公告)号：CA1307269C

公开(公告)日：1992-09-08

申请号：CA524507

申请日：1986-12-04

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  HASHIMOTO NAOTO

IPC: A61K31/365 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P31/00 ,  C07D311/00 ,  C07D313/00 ,  C07D493/08 ,  C07H15/00 ,  A61K31/395

Abstract: The present invention provides lankacidin derivative of the formula ¢1! ¢1! In the formula, one of R1 and R2 is H and the other is -C(=X)R5 ¢where X is O or S and R5 are an organic residue! or R1 and R2 together form ¢where R6 is acyl, sulfonyl or alkoxycarbonyl and R7 is alkyl!; R3 and R4 are OH, halogen, azido or an organic residue. The lankacidin derivative ¢1! shows excellent antimicrobial activities and thus can be used for prophylaxis and treatment of infectious disease in animals.

公开(公告)号：HUT45044A

公开(公告)日：1988-05-30

申请号：HU502486

申请日：1986-12-04

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  HASHIMOTO NAOTO

IPC: A61K31/365 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P31/00 ,  C07D311/00 ,  C07D313/00 ,  C07D493/08 ,  C07H15/00 ,  C07D311/94 ,  A61K31/35

公开(公告)号：CH633537A5

公开(公告)日：1982-12-15

申请号：CH959178

申请日：1978-09-13

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MATSUMURA KOICHI ,  MIYASHITA OSAMU ,  SHIMADZU HIROSHI ,  HASHIMOTO NAOTO

IPC: A61K31/505 ,  A61P31/12 ,  A61P35/00 ,  A61P35/02 ,  C07D233/90 ,  C07D239/22 ,  C07D333/00 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

公开(公告)号：CH632748A5

公开(公告)日：1982-10-29

申请号：CH373577

申请日：1977-03-24

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MIYASHITA OSAMU ,  MATSUMURA KOICHI ,  SHIMADZU HIROSHI ,  HASHIMOTO NAOTO

IPC: A61K31/513 ,  A61P35/00 ,  C07C273/18 ,  C07C275/20 ,  C07C275/50 ,  C07D239/22 ,  C07D239/54 ,  C07D239/553 ,  C07D239/557 ,  C07D405/04 ,  C07F7/18 ,  C07D233/66 ,  C07D233/96

公开(公告)号：CA1097627A

公开(公告)日：1981-03-17

申请号：CA316118

申请日：1978-11-10

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HASHIMOTO NAOTO ,  KISHI TOYOKAZU

IPC: C07D498/04 ,  C07D498/18

Abstract: Method for the Production of Maytansinoids Maytansinoid compounds are produced by contacting in the presence of a carbodiimide the compound maytansinol with an acid of the formula: (II) wherein R is lower alkyl, to yield the desired maytansinoids having the resultant formula: (I) wherein R is lower alkyl. The maytansinoids (I) are both antifungal agents and also antitumor agents. The D-form (with respect to asymmetry at the 2'position) of the maytansinoids (I) represents a new class of compounds having antifungal and antitumor properties.

公开(公告)号：CA1081226A

公开(公告)日：1980-07-08

申请号：CA274676

申请日：1977-03-24

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MIYASHITA OSAMU ,  MATSUMURA KOICHI ,  SHIMADZU HIROSHI ,  HASHIMOTO NAOTO

IPC: A61K31/513 ,  A61P35/00 ,  C07C273/18 ,  C07C275/20 ,  C07C275/50 ,  C07D239/22 ,  C07D239/54 ,  C07D239/553 ,  C07D239/557 ,  C07D405/04 ,  C07F7/18

Abstract: of the disclosure New derivatives of the formula: (wherein X is O or NH; R1 is -OH or -SH which may optionally be etherified or esterified, or -NH2 which may optionally be substituted; R2 and R3, respectively, mean H, lower alkyl or ; and Y is an esterified or amidated carboxyl group, or CN). These derivatives are produced, by fluorination of corresponding 1,2,3,4tetrahydro-2,4-dioxopyrimidine compounds and can be converted into 5-fluorouracil derivatives under hydrolytic conditions The new derivatives are able to prolong the lives of animals having carcinomas or have antiviral activity.