公开(公告)号：KR820001543B1

公开(公告)日：1982-08-31

申请号：KR780002819

申请日：1978-09-16

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MATSUMURA KOICHI ,  MIYASHITA OSAMU ,  SIMATSU HIROSHI ,  HASHIMOTO NAOTO

IPC: A61K31/505 ,  C07D239/54

Abstract: Title compds. (I; R1 = lower alkyl; R4-CO- is residue of carboxylic acid; R2, R3 = phenyl, alkylidene, cycloalkylidene), having antivirus activity, were prepd. by reacting compd. (II) with compd. (III). Thus, anhydrous acetic acid 2.55 g and pyridine 10 ml were added in the soln. of acetone 6 ml and methyl-5-fluoro-6-hydroxy-1,2,3,4,5,6-hexa hydro-2,4-dioxopyrimidine-5-carboxylate 4.12 g, stirred for 12 hr and then cyclohexanone oxime 2.26 g was added. The reaction mixt. was stirred at room temp. for 2 hr and reacted at 65≦̸C for 3 hr to give methyl-5-fluoro-6-cyclohexylidene aminooxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylic acid 4.0 g.

公开(公告)号：US3634488A

公开(公告)日：1972-01-11

申请号：US3634488D

申请日：1969-08-12

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MORITA KATSURA ,  HASHIMOTO NAOTO ,  MORIMOTO SHIRO ,  ANDO YASUO ,  MIYASHIRO YUTAKA

IPC: C07C121/30

CPC classification number: C07C255/00

Abstract: CYANOACETYLENE IS PRODUCED BY THE GAS PHASE REACTION OF ACRYLONITRILE AND CHLORINE, AT 500* TO 1,200*C.

公开(公告)号：US3598834A

公开(公告)日：1971-08-10

申请号：US3598834D

申请日：1968-12-13

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MORITA KATSURA ,  HASHIMOTO NAOTO ,  MATSUMURA KOICHI

IPC: C07D261/14 ,  C07D85/22

CPC classification number: C07D261/14

Abstract: 3-AMINOISOXAZOLE IS PRODUCED BY SUBJECTING A NOVEL ALKYLIDENEAMINOXYACRYLONITRILE OF THE FORMULA

R=N-O-CH=CH-CN

WHEREIN R=AN ALKYLIDENE GROUP HAVING 2 TO 8 CARBON ATOMS TO HYDROLYSIS AND RING-CLOSURE AT A TEMPERATURE OF -10* TO 100*C. UNDER ACIDIC CONDITIONS IN HIGH YIELDS AND WITHOUT BEING ACCOMPANIED BY ANY APPRECIABLE QUANTITIES OF BY-PRODUCT.

公开(公告)号：US3497548A

公开(公告)日：1970-02-24

申请号：US3497548D

申请日：1967-05-31

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MORITA KATSURA ,  HASHIMOTO NAOTO

IPC: C07C21/04 ,  C07C121/00

CPC classification number: C07C21/04

公开(公告)号：US3493600A

公开(公告)日：1970-02-03

申请号：US3493600D

申请日：1967-07-21

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MORITA KATSURA ,  HASHIMOTO NAOTO

IPC: C07C121/30

CPC classification number: C07C255/00

公开(公告)号：US3502709A

公开(公告)日：1970-03-24

申请号：US3502709D

申请日：1967-09-05

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MORITA KATSURA ,  HASHIMOTO NAOTO ,  SARAIE TAKAHIRO

IPC: C07C9/14 ,  C07C51/41 ,  C07C121/22

CPC classification number: C07C255/00

公开(公告)号：US3441593A

公开(公告)日：1969-04-29

申请号：US3441593D

申请日：1967-03-14

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： HASHIMOTO NAOTO ,  MORITA KATSURA

IPC: C07C121/28

CPC classification number: C07C255/00

公开(公告)号：AT94549T

公开(公告)日：1993-10-15

申请号：AT86116752

申请日：1986-12-02

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  HASHIMOTO NAOTO

IPC: A61K31/35 ,  C07D493/08

公开(公告)号：AU526302B2

公开(公告)日：1983-01-06

申请号：AU4657379

申请日：1979-05-01

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MATSUMURA KOICHI ,  HASHIMOTO NAOTO ,  FURUKAWA YOSHIYASU

IPC: A61K31/415 ,  A61P7/10 ,  A61P9/12 ,  C07D233/68 ,  C07D333/00 ,  C07D405/04 ,  C07D409/04

Abstract: Novel imidazole derivatives of the formulawherein R' is hydrogen, nitro or amino, R 2 is a phenyl, furyl or thienyl group which may be substituted by halogen, lower alkyl, lower alkoxy or di-lower-alkylamino, R 3 is hydrogen or lower alkyl and X is halogen, and their physiologically acceptable salts, have excellent diuretic and hypotensive actions.

公开(公告)号：AU4657379A

公开(公告)日：1979-11-22

申请号：AU4657379

申请日：1979-05-01

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MATSUMURA KOICHI ,  HASHIMOTO NAOTO ,  FURUKAWA YOSHIYASU

IPC: A61K31/415 ,  A61P7/10 ,  A61P9/12 ,  C07D233/68 ,  C07D333/00 ,  C07D405/04 ,  C07D409/04

Abstract: Novel imidazole derivatives of the formulawherein R' is hydrogen, nitro or amino, R 2 is a phenyl, furyl or thienyl group which may be substituted by halogen, lower alkyl, lower alkoxy or di-lower-alkylamino, R 3 is hydrogen or lower alkyl and X is halogen, and their physiologically acceptable salts, have excellent diuretic and hypotensive actions.