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    NEW FLUORESCENT PIGMENT AND METHOD FOR MEASURING NUCLEIC ACID
    31.
    发明专利
    NEW FLUORESCENT PIGMENT AND METHOD FOR MEASURING NUCLEIC ACID 审中-公开

    公开(公告)号：JP2002327130A

    公开(公告)日：2002-11-15

    申请号：JP2002005267

    申请日：2002-01-11

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  ISHIGURO NORIHIKO ,  HORIE RYUICHI

    IPC: G01N33/58 ,  C07D417/14 ,  C07H21/04 ,  C09B23/00 ,  C09K11/06 ,  C12N15/09 ,  C12Q1/68

    Abstract: PROBLEM TO BE SOLVED: To provide a new fluorescent intercalative dye or the like which shows a large fluorescent enhancement upon intercalation into a double-stranded nucleic acid when used in detection of the nucleic acid, shows a great difference between the excitation wavelength and the fluorescence wavelength (i.e., has a large Stokes shift). SOLUTION: The purpose is attained by providing a compound represented by general formula 1, particularly e.g. compound 1 represented by formula 1A or a salt, hydrate, solvate or stereoisomer thereof, a method for producing these compounds and a nucleic acid probe obtained by bringing these compounds into contact with a nucleic acid or a nucleic acid probe obtained by chemically bonding these compounds to a single-stranded oligonucleotide.

    3-AMINOTHIOPHENE DERIVATIVE
    34.
    发明专利
    3-AMINOTHIOPHENE DERIVATIVE 失效

    公开(公告)号：JP2000026455A

    公开(公告)日：2000-01-25

    申请号：JP19394498

    申请日：1998-07-09

    Applicant: TOSOH CORP

    Inventor： YAMAMOTO TAKASHI ,  TOKUNAGA TAKUMI ,  ITO HIROYUKI ,  KONO KAZUHISA ,  HANAZAKI YASUAKI ,  KATSUURA KIMIO

    IPC: C07D333/36

    Abstract: PROBLEM TO BE SOLVED: To obtain a new 3-aminothiophene derivative useful as a synthetic intermediate, etc., of various physiologically active substances such as a medicine, an agrochemical, etc. SOLUTION: This new 3-aminothiophene derivative is a compound of formula I [R1, R2 are H, F, nitro, a lower alkyl, a alkoxy, a lower alkoxycarbonyl or a lower acryl; R3 is a lower alkyl; R4 to R7 are each H or a lower alkyl), e.g. N-(2-hydroxyethyl)-N-methyl-3-aminothiophene. Further, the compound of the formula I is obtained by reacting a 3-halothiophene derivative of formula II (X is a halogen) with an aminoalcohol derivative of formula III in an inert organic solvent such as tetrahydrofuran in the presence of a base such as triethylamine.

    HALOGENATED THIOFORMATE DERIVATIVE AND ITS PRODUCTION
    36.
    发明专利
    HALOGENATED THIOFORMATE DERIVATIVE AND ITS PRODUCTION 失效

    公开(公告)号：JPH10204057A

    公开(公告)日：1998-08-04

    申请号：JP1248597

    申请日：1997-01-27

    Applicant: TOSOH CORP ,  GREEN CROSS CORP

    Inventor： TOKUNAGA TAKUMI ,  ITO HIROYUKI ,  KONO KAZUHISA ,  YAMAMOTO TAKASHI ,  KATSUURA KIMIO

    IPC: C07C215/50 ,  C07C233/25 ,  C07C255/36 ,  C07C329/02 ,  C07F7/12

    Abstract: PROBLEM TO BE SOLVED: To simply and economically produce the subject derivative, having a readily modifiable substituent group and useful as a production intermediate for physiologically active substances by reacting a phenol compound with a halogenothiocarbamating agent. SOLUTION: This compound is represented by formula I (R is a tri-lower alkylsilyl, a group represented by formula II (R1 is a lower alkoxy, cyano, a lower alkoxycarbonyl, etc.), etc.; V is a halogen), e.g. 4-(2-amino-1,1- dimethylethyl)phenoxy-tert-butyldimethylsilane. The objective derivative is preferably produced by reacting, e.g. a phenol compound represented by formula III with a halogenothiocarbamating agent, e.g. thiophosgene in the presence of a base in or without a solvent at -10 to +10 deg.C for several min to 24hr.

    TETRAHYDROISOQUINOLONE DERIVATIVE, ITS PRODUCTION AND FUNGICIDE COMPRISING THE SAME DERIVATIVE
    37.
    发明专利
    TETRAHYDROISOQUINOLONE DERIVATIVE, ITS PRODUCTION AND FUNGICIDE COMPRISING THE SAME DERIVATIVE 失效

    公开(公告)号：JPH05186426A

    公开(公告)日：1993-07-27

    申请号：JP35950091

    申请日：1991-12-30

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  TAKASU YASUHITO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI ,  IDE TERUHIKO

    IPC: A01N43/42 ,  C07D217/26 ,  C07D405/04

    Abstract: PURPOSE:To obtain a new tetrahydroisoquinolone derivative showing sufficient effects and no problems in terms of environmental toxicity in the case of use as a fungicide. CONSTITUTION:Compounds of formula I and formula II [R is 1-5C alkyl, 2-5C alkenyl or 2-5C alkynyl; R to R are H, 1-10C alkyl, 3-10C alkenyl, 2-10C alkynyl, 1-10C alkoxy, 2-10C alkenyloxy, 2-10C alkynyloxy, benzyloxy, OH, halogenated alkyl, NH2, amino substituted or disubstituted with 1-4C alkyl, phenyl, halogen, group of formula III or formula IV (R is 1-10C alkyl; R and R are H or R ) or R and R or R and R are bonded to form group formula V (m is 1 or 2) or formula VI] such as 3-(4-t-butylphenyl)-4-hydroxycarbonyl-2- methyl-1-oxo-1,2,3,4-tetrahydroisoquinoline. The compound of formula I is obtained by reacting an imine derivative of formula Vll with homophthalic anhydride in a solventless state or in the presence of a solvent preferably at 0-100 deg.C.

    SULFONAMIDE DERIVATIVE, PREPARATION THEREOF AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT
    38.
    发明专利
    SULFONAMIDE DERIVATIVE, PREPARATION THEREOF AND HERBICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT 失效

    公开(公告)号：JPH03258771A

    公开(公告)日：1991-11-19

    申请号：JP5653290

    申请日：1990-03-09

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  SAKKA YASUO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI

    IPC: C07D271/06 ,  A01N43/82 ,  A01N43/836

    Abstract: NEW MATERIAL:A compound of formula I [X is 1-4C alkyl, hydroxy, 1-4C alkoxy, amino, nitro, halogen; X is H, halogen; X is not H when X is 4-amino; R is H, 1-4C alkyl, COOR (R is 1-4C alkyl), phenyl, etc.; Y is H, 1-6C alkyl, 3-4C alkenyl, 3-4C alkinyl, 2-6C alkyl sustitutable at O]. EXAMPLE:5-Methyl-3-(4-methylphenyl sulfonylamino)-1,2,4-oxadiazole. USE:A herbicide. The compound of formula I exhibits an excellent herbicidal activity against upland or rice field weeds such as E chinochloa, Cyperus and Scirpus and has high safety to crops. PREPARATION:A hydroxy guanidine derivative of formula II is reacted with an acid halide of formula III (X is halogen) or an acid anhydride of formula IV to provide the compound of formula I.

    HERBICIDE CONTAINING SULFONAMIDE DERIVATIVE AS ACTIVE COMPONENT
    39.
    发明专利
    HERBICIDE CONTAINING SULFONAMIDE DERIVATIVE AS ACTIVE COMPONENT 失效

    公开(公告)号：JPH03258703A

    公开(公告)日：1991-11-19

    申请号：JP5653390

    申请日：1990-03-09

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  SAKKA YASUO ,  WATANABE HIROYUKI ,  TSUZUKI KENJI

    IPC: A01N43/836 ,  A01N43/82

    Abstract: PURPOSE:To obtain a herbicide capable of controlling various weeds from the pre-sprouting stage to growing stage and having high safety to crops by using a sulfonamide derivative having oxadiazole ring and its salt as an active component. CONSTITUTION:The objective herbicide contains a compound of formula [X is alkyl, OH, alkoxy, NH2, NO2 or halogen; X is H or halogen; R is H, alkyl, COOR (R is alkyl), phenyl, benzyl, etc.; Y is H, alkyl, alkenyl, alkynyl, etc.) and its salt (e.g. salts produced by NaOH, ammonia, etc.] as an active component. The herbicide can be used in combination with other agricultural chemicals such as fungicide, insecticide, herbicide and plant growth regulator. Especially, the labor can be saved and the herbicidal spectrum is expected to be expanded by the mixed use with other herbicide. The rate of application is 10-500g of the active component per 10 are.

    OPTICALLY ACTIVE LACTIC ESTER DERIVATIVE AND PRODUCTION THEREOF
    40.
    发明专利
    OPTICALLY ACTIVE LACTIC ESTER DERIVATIVE AND PRODUCTION THEREOF 失效

    公开(公告)号：JPH02215777A

    公开(公告)日：1990-08-28

    申请号：JP3622289

    申请日：1989-02-17

    Applicant: TOSOH CORP

    Inventor： TOKUNAGA TAKUMI ,  KAGAWA TAKUMI ,  WATANABE HIROYUKI ,  TSUZUKI KENJI

    IPC: C07D307/12 ,  A01N43/08

    Abstract: NEW MATERIAL:An optically active lactic ester derivative expressed by formula I [R is 1-3C alkyl, benzyl or phenyl (able to be 1-3 substituted by methyl, isopropyl, methoxy, nitro or amino, etc.)]. EXAMPLE:(2S)-tetrahydrofurfuryl 2-p-toluenesulfonyloxy propionate. USE:Producing intermediate of physics or agricultural chemicals, etc. PREPARATION:Alkylsulfonic acid halide expressed by formula II (X is halogen) is reacted with optically active (2S)-tetrahydrofurfuryl 2-hydroxy propionate to obtain the compound expressed by formula I.

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