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公开(公告)号：US11768150B2
公开(公告)日：2023-09-26
申请号：US17881996
申请日：2022-08-05
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng , Lu Lan , Jiaze Yin
CPC classification number: G01N21/171 , G01N21/35 , G01N21/47 , G01N2021/3595
Abstract: Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain.
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公开(公告)号：US11692996B2
公开(公告)日：2023-07-04
申请号：US17839080
申请日：2022-06-13
Applicant: Trustees of Boston University , Northwestern University
Inventor： Ji-Xin Cheng , Junjie Li , Yuying Tan , Daniela Matei , Guangyuan Zhao
IPC: G01J3/44 , G01N33/49 , G01N27/416 , G01Q60/60 , G16H20/10 , G16H50/30 , G01N33/487 , G01N27/30 , G01N21/65
CPC classification number: G01N33/492 , G01N27/30 , G01N27/416 , G01N33/48735 , G01Q60/60 , G16H20/10 , G16H50/30 , G01N21/65 , G01N2800/52
Abstract: Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.
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公开(公告)号：US20230045375A1
公开(公告)日：2023-02-09
申请号：US17881996
申请日：2022-08-05
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng , Lu Lan , Jiaze Yin
Abstract: Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain.
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公开(公告)号：US20240255429A1
公开(公告)日：2024-08-01
申请号：US18424128
申请日：2024-01-26
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng
IPC: G01N21/65
CPC classification number: G01N21/65 , G01N2201/06113 , G01N2201/105
Abstract: A stimulated Raman photothermal (SRP) microscope for imaging a sample. A first optical source omits an intensity-modulated pump beam. A second optical source omits an intensity-modulated Stokes beam. The Stokes beam is combined with the pump beam to form a combined beam. The combined beam is directed to the sample to induce a thermal effect caused by the stimulated Raman process. A third optical source emits a probe beam, the probe beam is directed to the sample. An optical detector detects modulation of the probe beam after modulation by the sample to measure an SRP signal.
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公开(公告)号：US11982615B2
公开(公告)日：2024-05-14
申请号：US18127388
申请日：2023-03-28
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng , Lu Lan , Jiaze Yin
CPC classification number: G01N21/171 , G01N21/35 , G01N21/47 , G01N2021/3595
Abstract: Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain.
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Patent Agency Ranking
公开(公告)号：US11913881B2
公开(公告)日：2024-02-27
申请号：US18100347
申请日：2023-01-23
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng , JIan Zhao , Lei Tian , Alex Matlock
CPC classification number: G01N21/636 , G01N2021/637 , G01N2021/655
Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.
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公开(公告)号：US20240035979A1
公开(公告)日：2024-02-01
申请号：US18235279
申请日：2023-08-17
Applicant: Trustees of Boston University
Inventor： Ji-Xin Cheng , Haonan Lin
CPC classification number: G01N21/65 , G06T5/001 , G06N3/04 , G06N3/08 , G06T2207/20081 , A61B5/0075
Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.
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公开(公告)号：US11883344B2
公开(公告)日：2024-01-30
申请号：US18103093
申请日：2023-01-30
Applicant: Trustees of Boston University
Inventor： Chen Yang , Ji-Xin Cheng
CPC classification number: A61H23/00 , A61N5/0603 , A61H2201/10 , A61N2005/063 , A61N2005/0659 , A61N2005/0663
Abstract: An example photoacoustic system for neurostimulation includes a light producing device for producing light of a specific wavelength. At least one nanotransducer is binded on a surface of a neuron. The nanotransducer converts the light with the specific wavelength into at least one acoustic wave at or near the neuron.
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公开(公告)号：US20230240935A1
公开(公告)日：2023-08-03
申请号：US18103093
申请日：2023-01-30
Applicant: Trustees of Boston University
Inventor： Chen Yang , Ji-Xin Cheng
CPC classification number: A61H23/00 , A61N5/0603 , A61H2201/10 , A61N2005/0659 , A61N2005/0663 , A61N2005/063
Abstract: An example photoacoustic system for neurostimulation includes a light producing device for producing light of a specific wavelength. At least one nanotransducer is binded on a surface of a neuron. The nanotransducer converts the light with the specific wavelength into at least one acoustic wave at or near the neuron.
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公开(公告)号：US11684404B2
公开(公告)日：2023-06-27
申请号：US17690948
申请日：2022-03-09
Applicant: Trustees of Boston University
Inventor： Chen Yang , Ji-Xin Cheng , Nan Zheng , Yueming Li , Ying Jiang , Lu Lan , Linli Shi
IPC: A61B18/04 , B01J19/10 , B82Y40/00 , B82Y30/00 , A61B5/00 , A61B18/26 , A61B8/00 , A61B18/22 , G01N29/24 , G01S15/89 , F21V8/00 , G02B6/02 , G02B6/34
CPC classification number: A61B18/04 , A61B5/0095 , A61B18/26 , B01J19/10 , B82Y30/00 , B82Y40/00 , A61B5/0035 , A61B5/0059 , A61B8/4416 , A61B8/4483 , A61B2018/2205 , A61B2018/2244 , A61B2018/2261 , A61B2018/266 , G01N29/2431 , G01S15/8968 , G02B6/004 , G02B6/021 , G02B6/02033 , G02B6/02104 , G02B6/34
Abstract: A tapered fiber optoacoustic emitter includes a nanosecond laser configured to emit laser pulses and an optic fiber. The optic fiber includes a tip configured to guide the laser pulses. The tip has a coating including a diffusion layer and a thermal expansion layer, wherein the diffusion layer includes epoxy and zinc oxide nanoparticles configured to diffuse the light while restricting localized heating. The thermal expansion layer includes carbon nanotubes (CNTs) and Polydimethylsiloxane (PDMS) configured to convert the laser pulses to generate ultrasound. The frequency of the ultrasound is tuned with a thickness of the diffusion layer and a CNT concentration of the expansion layer.
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