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公开(公告)号：AT451460T
公开(公告)日：2009-12-15
申请号：AT01934209
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/13 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/21 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/08
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±
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公开(公告)号：MY136603A
公开(公告)日：2008-10-31
申请号：MYPI20012634
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: THERE IS DISCLOSED ANTIBODY MOLECULES CONTAINING AT LEAST ONE CDR DERIVED FROM A MOUSE MONOCLONAL ANTIBODY HAVING SPECIFICITY FOR HUMAN TNF . THERE IS ALSO DISCLOSED A CDR GRAFTED ANTIBODY WHEREIN AT LEAST ONE OF THE CDR'S IS A HYBRID CDR. FURTHER DISCLOSED ARE DNA SEQUENCES ENCODING THE CHAINS OF THE ANTIBODY MOLECULES, VECTORS, TRANSFORMED HOST CELLS AND USES OF THE ANTIBODY MOLECULES IN THE TREATMENT OF DISEASES MEDIATED BY TNF .
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33.发明专利
公开(公告)号：NO20131316A
公开(公告)日：2002-04-08
申请号：NO20131316
申请日：2013-10-01
Applicant: UCB PHARMA SA
Inventor： KING DAVID JOHN , ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL
IPC: C07K16/24 , C12N15/09 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08
CPC classification number: C07K16/241 , A61K47/6845 , A61K47/6875 , A61K2039/505 , C07K2317/24 , C07K2317/565
Abstract: Oppfinnelsen angår et antistoffmolekyl med spesifisitet for human TNFa, og angår også DNA sekvenser som koder for kjedene til antistoffmolekylet, vektorer, transformerte vertceller, fremgangsmåte for fremstilling av antistoffmolekylet, et terapeutisk/diagnostisk preparat samt anvendelser av antistoffmolekylet for behandling av sykdommer mediert ved TNFa.
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34.发明专利
公开(公告)号：SK288706B6
公开(公告)日：2019-10-02
申请号：SK500812015
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C07K16/24 , A61K39/395 , A61K47/68 , A61P19/02 , A61P37/06 , C07K16/46 , C07K19/00 , C12N1/21 , C12N15/13 , C12N15/62 , C12N15/70
Abstract: Vynález sa týka protilátkových molekúl, ktoré sú špecifické pre antigénne determinanty nádorového nekrotického faktora alfa (TNFα). Na C-konci ťažkého reťazca týchto molekúl je pripojená efektorová alebo reportérová molekula, výhodne metoxypoly(etylénglykol). Vynález sa ďalej týka terapeutického použitia protilátkových molekúl na liečenie chorôb sprostredkovaných TNFα.
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Patent Agency Ranking35.发明专利
公开(公告)号：DK3059314T3
公开(公告)日：2019-02-18
申请号：DK16154916
申请日：2001-06-05
Applicant: UCB PHARMA SA
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公开(公告)号：HU230561B1
公开(公告)日：2016-12-28
申请号：HU0202346
申请日：2001-06-05
Applicant: UCB PHARMA SA
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37.发明专利
公开(公告)号：DK2308975T3
公开(公告)日：2016-10-31
申请号：DK10010795
申请日：2001-06-05
Applicant: UCB PHARMA SA
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38.发明专利
公开(公告)号：SI2230308T1
公开(公告)日：2013-06-28
申请号：SI200131020
申请日：2001-06-05
Applicant: UCB PHARMA SA
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公开(公告)号：DE60140738D1
公开(公告)日：2010-01-21
申请号：DE60140738
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/13 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/21 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/08
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±
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