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1.发明专利
公开(公告)号：CY1121173T1
公开(公告)日：2020-05-29
申请号：CY191100095
申请日：2019-01-24
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/13 , A61K39/395 , A61K47/48 , A61K47/68 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12P21/02 , C12P21/08
Abstract: Περιγράφονταιμόριααντισωμάτωνπουπεριέχουντουλάχιστονένα CDR προερχόμενοαπόμονοκλωνικάαντισώματαποντικού, μεειδικότηταπροςτονανθρώπινο TNFα. Περιγράφεταιεπίσηςένα CDR μοσχευμένοαντίσωμαόπουτουλάχιστονένααπότα CDR είναιέναυβριδικό CDR. Περιγράφονταιεπιπλέοναλληλουχίες DNA πουκωδικοποιούντιςαλυσίδεςτωναντισωμάτων, φορείς, μετασχηματισμένακύτταραξενιστέςκαιχρήσειςτωναντισωμάτωνγιατηνθεραπείανοσημάτωνπουδιαμεσολαβούνταιαπότον TNFα.
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公开(公告)号：LU91674I9
公开(公告)日：2019-01-03
申请号：LU91674
申请日：2010-03-29
Applicant: UCB PHARMA SA
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3.发明专利
公开(公告)号：LT2308975T
公开(公告)日：2016-11-10
申请号：LT10010795
申请日：2001-06-05
Applicant: UCB PHARMA SA
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公开(公告)号：CA2707766C
公开(公告)日：2013-05-21
申请号：CA2707766
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/63 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF.alpha.. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF.alpha..
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公开(公告)号：ES2403217T3
公开(公告)日：2013-05-16
申请号：ES09176251
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/13 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/21 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/08
Abstract: Una molécula de anticuerpo que tiene especificidad por el TNFα humano, caracterizada por que comprende a) una cadena pesada en la que el dominio variable comprende (i) una CDRH1 con la secuencia dada como SEC ID NO: 1 (H1 en la Figura 3), (ii) una CDRH2 como la secuencia dada como SEC ID NO: 2 (H2' en la Figura 3) o como SEC ID 5 NO: 7 (H2 en la Figura 3), y (iii) una CDRH3 con la secuencia dada como SEC ID NO: 3 (H3 en la figura 3), y b) una cadena ligera en la que el dominio variable comprende (i) una CDRL1 con la secuencia dada como SEC ID NO: 4 (L1 en la Figura 3), (ii) una CDRL2 como la secuencia dada como SEC ID NO: 5 (L2 en la Figura 3) y (iii) una CDRL3 con la secuencia dada como SEC ID NO: 6 (L3 en la figura 3), y .
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Patent Agency Ranking6.发明专利
公开(公告)号：DK2230308T3
公开(公告)日：2013-05-06
申请号：DK09176251
申请日：2001-06-05
Applicant: UCB PHARMA SA
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公开(公告)号：PT2230308E
公开(公告)日：2013-05-03
申请号：PT09176251
申请日：2001-06-05
Applicant: UCB PHARMA SA
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8.发明专利
公开(公告)号：IS2808B
公开(公告)日：2012-09-15
申请号：IS6217
申请日：2002-01-03
Applicant: UCB PHARMA SA
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9.发明专利
公开(公告)号：HK1148776A1
公开(公告)日：2011-09-16
申请号：HK11102887
申请日：2011-03-22
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N20060101 , A61K39/395 , C12N15/09 , A61K47/48 , A61P20060101 , A61P19/02 , A61P29/00 , A61P37/06 , C07K20060101 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±
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10.发明专利
公开(公告)号：HK1051385A1
公开(公告)日：2003-08-01
申请号：HK03103635
申请日：2003-05-22
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , A61K39/395 , A61K47/48 , A61P20100101 , A61P19/02 , A61P29/00 , A61P37/06 , C07K20100101 , C07K16/24 , C07K16/46 , C12N20100101 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±
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