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    2-AMINO-4-MORPHOLINO-6-PROPYL-1,3,5-TRIAZINES
    31.
    发明专利
    2-AMINO-4-MORPHOLINO-6-PROPYL-1,3,5-TRIAZINES 未知

    公开(公告)号：HK95693A

    公开(公告)日：1993-09-24

    申请号：HK95693

    申请日：1993-09-16

    Applicant: UCB SA

    Inventor： COSSEMENT ERIC ,  GOBERT JEAN ,  BOYDENS ROLAND ,  MATHIEU JACQUES

    IPC: C07D413/04 ,  A61K31/53 ,  A61K31/535 ,  A61K31/5377 ,  A61P21/02 ,  A61P25/28 ,  A61P27/06 ,  C07D251/18

    Abstract: New 2-amino-4-morpholino-6-propyl-1,3,5-triazines having the formula (I) wherein R1 is hydrogen, alkyl, aralkyl or acetyl, R2 is hydroxyl, hydroxyalkyl, alkoxyalkyl, dialkylamino, arylhydroxyalkyl, (hydroxy-cycloalkyl)alkyl, alkanoyloxyalkyl, benzoyloxyalkyl, phenylacetyloxyalkyl, aminocarbonyloxyalkyl, COR3 or CONR4R5, or NR1R2=(hydroxyalkyl)alkyleneimino, R3=alkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, aralkyl or aryloxy, R4=R5=hydrogen or alkyl, alkyl, alkoxy and alkanoyloxy having 1 to 4 carbon atoms, cycloalkyl and alkyleneimino having 4 to 6 carbon atoms. Moreover, when R1 is acetyl, R2 is acetoxyalkyl. Processes for the preparation thereof and pharmaceutical compositions containing the same are also given. In particular, these compounds are useful for the treatment of cognitive and behavioral disorders associated with aging and dementia syndromes, e.g. those associated with Alzheimer's disease.

    32.
    发明专利
    未知

    公开(公告)号：NO173331B

    公开(公告)日：1993-08-23

    申请号：NO891760

    申请日：1989-04-27

    Applicant: UCB SA

    Inventor： COSSEMENT ERIC ,  GEERTS JEAN-PIERRE ,  GOBERT JEAN ,  MICHEL PHILIPPE ,  WUELFERT ERNST

    IPC: A61K31/415 ,  A61K31/4164 ,  C07D233/56 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P25/02 ,  A61P29/00 ,  C07D233/54 ,  C07D233/64 ,  C07D403/10

    Abstract: New substituted 1-(1H-imidazol-4-yl)alkyl-benzamides and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula wherein R1, R2=hydrogen or C1-C4-alkyl, R3=hydrogen, amino, hydroxyl, C1-C4-alkyl or C1-C4-hydroxyalkyl, R4=hydrogen or C1-C4-alkyl, or R3R4N=pyrrolidino, piperidino or morpholino, R5 and R6=hydrogen, hydroxyl, C1-C4-alkyl or C1-C4-alkoxy, at least one of R5 and R6 being other than hydrogen. These compounds are prepared either by reacting a nitrogen compound with an alkyl 1-(1H-imidazol-4-yl)alkyl-benzoate or with a 1-(1H-imidazol-4-yl)alkyl-benzoic acid, or by hydrolyzing in an acid medium a 2-hydroxy-3-[1-(1H-imidazol-4-yl)alkyl]-benzonitrile. The compounds have anti-ischemic and alpha 2-adrenoceptor agonist activities.

    36.
    发明专利
    未知

    公开(公告)号：NO172287B

    公开(公告)日：1993-03-22

    申请号：NO894650

    申请日：1989-11-22

    Applicant: UCB SA

    Inventor： BODSON GUY ,  COSSEMENT ERIC ,  GOBERT JEAN

    IPC: C07D295/08 ,  C07D295/088

    Abstract: A process for the preparation of 2-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid and its dihydrochloride, wherein 2-[4-[(4-chlorophenyl-phenylmethyl]-1-piperazinyl]1-1ethanol is reacted with an alkali metal halogenoacetate in the presence of an alkali metal alcoholate, the alkali metal salt thus obtained is converted into the corresponding acid and, if appropriate, into its dihydrochloride.

    40.
    发明专利
    未知

    公开(公告)号：DK163501C

    公开(公告)日：1992-07-27

    申请号：DK212985

    申请日：1985-05-14

    Applicant: UCB SA

    Inventor： GOBERT JEAN ,  GEERTS JEAN-PIERRE ,  BODSON GUY

    IPC: C07D207/26 ,  A61K31/40 ,  A61K31/4015 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  C07D207/12 ,  C07D207/27 ,  C07D207/277 ,  C07D295/185

    Abstract: (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide, its preparation and pharmaceutical compositions containing the same. It can be prepared either by reacting (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetic acid successively with an alkyl haloformate and with ammonia, or, by cyclizing an (S)-2-amino-butanamide of the formula X-CH2CH2-NHCH (C2H5)CONH2 wherein Y is a -CH2-radical when X represents a ZOOC-radical and Y is a -CO- radical when X represents a HalCH2-radical, Z being a C1-C4 alkyl radical and Hal a halogen atom. This laevorotatory enantiomer has been found to have significantly higher protective activity against hypoxia and ischemia than the corresponding racemate.

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