公开(公告)号：WO1998015179A1

公开(公告)日：1998-04-16

申请号：PCT/US1997018145

申请日：1997-10-08

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  CASTILLO, Gerardo ,  SNOW, Alan, D.

IPC: A01N37/18

CPC classification number: C07K14/78 ,  A61K38/00

Abstract: The invention relates to the discovery, identification and use of laminin, laminin-derived protein fragments, and laminin-derived polypeptides, as well as related peptides and antibodies, for the therapeutic intervention and diagnosis of Alzheimer's disease and other amyloidoses. In addition, the discovery and identification of an Alzheimer's beta-amyloid protein specific binding within the globular domain repeats of the laminin A chain, had led to new diagnostic and therapeutic applications for Alzheimer's disease and other amyloidoses which are disclosed.

Abstract translation: 本发明涉及层粘连蛋白，层粘连蛋白衍生蛋白片段和层粘连蛋白衍生多肽以及相关肽和抗体的发现，鉴定和使用，用于治疗性介入和诊断阿尔茨海默病和其他淀粉样变性。 此外，在层粘连蛋白A链的球状结构域重复序列中发现和鉴定阿尔茨海默氏症β-淀粉样蛋白特异性结合已导致新公认的阿尔茨海默病和其他淀粉样变性的诊断和治疗应用。

公开(公告)号：WO1998005510A2

公开(公告)日：1998-02-12

申请号：PCT/US1997012835

申请日：1997-08-01

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  POWER, Joanna, L. ,  WEST, Brad, S. ,  STOLLNITZ, Eric, J. ,  SALESIN, David, H.

IPC: B41M00/00

CPC classification number: B32B5/26 ,  B32B5/028 ,  B32B2262/0253 ,  B32B2305/38 ,  B32B2307/54 ,  B32B2307/724 ,  B32B2307/726 ,  B41M3/008 ,  H04N1/56 ,  H04N1/6016 ,  H04N1/6058 ,  H04N1/6097 ,  Y10T442/197 ,  Y10T442/66 ,  Y10T442/668

Abstract: A full color process image that can be printed with cyan, magenta, yellow, and black inks is produced as a duotone image using only two colors of ink. Color data defining the colors used in the full color image serve as input to a process that maps the colors into a duotone gamut defined by the two colors of ink that will be used to produce the duotone image. A user is able to select 0, 1, or 2 colors of ink for the duotone image, and the software program automatically chooses the remaining ink or inks so as to reproduce the image as accurately as possible; the software also produces the appropriate color separations automatically. In addition, the paper color can be specified by the user or optimally determined by the optimizing process of the software to optimize the duotone image reproducing a full color image that has little white. The paper color provides a free third color. A black separation can also optionally be included when printing the duotone image to expand the range of luminance available. When black ink is used, some amount of black is subtracted from the each color of the original image before the optimization and mapping process is applied, and the black separation is determined to add back the appropriate amount of black when printing the duotone image. The duotone images produced by the method are relatively high-quality, economical alternatives to full-color printing.

Abstract translation: 可以使用青色，品红色，黄色和黑色墨水打印的全色过程图像仅使用两种颜色的油墨作为双色图像。 定义全色图像中使用的颜色的颜色数据用作将颜色映射到由用于产生双色图像的两种颜色的墨水定义的双色域的过程的输入。 用户能够为双色调图像选择0，1或2种颜色的墨水，并且软件程序自动选择剩余的墨水或墨水，以便尽可能准确地再现图像; 该软件还自动生成适当的分色。 此外，纸张颜色可以由用户指定或通过软件的优化处理最佳地确定，以优化双色调图像，再现具有小白色的全色图像。 纸张颜色提供免费的第三种颜色。 当打印双色图像以扩大可用亮度的范围时，也可以包括黑色分离。 当使用黑色墨水时，在应用优化和映射处理之前，从原始图像的每种颜色中减去一定量的黑色，并且确定黑色分离以在打印双色图像时添加适当量的黑色。 通过该方法生产的双色调图像是全彩色打印相对高质量，经济的替代品。

公开(公告)号：WO1997039338A1

公开(公告)日：1997-10-23

申请号：PCT/US1997005245

申请日：1997-03-31

Applicant: UNIVERSITY OF WASHINGTON ,  WEIGL, Bernhard, H. ,  YAGER, Paul ,  BRODY, James, P. ,  HOLL, Mark, R. ,  KENNY, Margaret ,  SCHUTTE, David ,  HIXSON, Gregory ,  ZEBERT, M., Diane ,  KAMHOLZ, Andrew ,  WU, Caicai ,  ALTENDORF, Eric

Inventor： UNIVERSITY OF WASHINGTON

IPC: G01N21/64

CPC classification number: B01F5/0403 ,  B01F13/0059 ,  B01F13/0093 ,  B01J19/0093 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00952 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0487 ,  G01N15/14 ,  G01N30/0005 ,  G01N30/38 ,  G01N30/6095 ,  G01N30/74 ,  G01N35/085 ,  Y10S366/01 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising a laminar flow channel (100), two inlet means (30, 20) in fluid connection with said laminar flow channel (100) for respectively conducting into the laminar flow channel (100) an indicator stream (70) which may comprise an indicator substance which indicates the presence of said analyte particles by a detectable change in property when contacted with said analyte particles, and the sample stream (80), wherein the laminar flow channel (100) has a depth sufficiently small to allow laminar flow of the streams and a length sufficient to allow particles of the analyte to diffuse into said indicator stream (70) to the substantial exclusion of said larger particles in the sample stream (80) to form a detection area; and outlet means (60) for conducting the streams out of the laminar flow channel (100) to form a single mixed stream.

Abstract translation: 提供了一种通道细胞系统，用于检测样品流中存在和/或测量分析物颗粒的存在，所述样品流包括层流通道（100），与所述层流通道流体连接的两个入口装置（30,20） 100），用于分别导入层流通道（100），指示物流（70），其可以包含指示物质，其指示当与所述分析物颗粒接触时通过可检测的性质变化指示所述分析物颗粒的存在，并且样品流 （80），其中所述层流通道（100）的深度足够小以允许所述流的层流，并且足够长度以允许所述分析物的颗粒扩散到所述指示物流（70）中，从而基本排除所述较大的 颗粒在样品流（80）中形成检测区域; 以及用于将流引导出层流通道（100）以形成单个混合流的出口装置（60）。

公开(公告)号：WO1997020501A2

公开(公告)日：1997-06-12

申请号：PCT/US1996019513

申请日：1996-12-06

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  KEEFE, Douglas, H.

IPC: A61B05/12

CPC classification number: A61B5/12 ,  A61B5/7232 ,  A61B5/7257 ,  G01H15/00 ,  G01N2291/02491 ,  G01N2291/02872

Abstract: A system for testing the auditory response of the human ear by measuring the linear and nonlinear power-based responses thereof uses a small probe assembly (50) containing a sound source (24, 52, 54) and microphone (30, 52, 56) inserted into the ear. The linear responses, or transfer functions, include reflectance, admittance and impedance. A calibration procedure is based upon measured pressure responses in one or more calibration waveguides (60), and upon a model of the transfer function of each of the calibration waveguides. The nonlinear responses are established by measuring the above transfer functions at different levels of the acoustic stimulus. By delivering changes in static pressure applied to the ear via an additional probe tube (68, 70) in the probe assembly (50), the system is able to measure the dependence on static pressure of any of these linear and nonlinear power-based functions.

Abstract translation: 一种用于通过测量其耳朵的听觉响应来测量其线性和非线性的基于功率的响应的系统使用包含声源（24,52,54）和麦克风（30,52,56）的小探针组件（50） 插入耳朵。 线性响应或传递函数包括反射率，导纳和阻抗。 校准过程基于在一个或多个校准波导（60）中测量的压力响应，以及每个校准波导的传递函数的模型。 通过在声学刺激的不同水平上测量上述传递函数来建立非线性响应。 通过经由探针组件（50）中的附加探针管（68,70）传送施加到耳朵的静压力的变化，该系统能够测量任何这些线性和非线性基于功率的功能对静态压力的依赖性 。

公开(公告)号：WO1997018840A2

公开(公告)日：1997-05-29

申请号：PCT/US1996018850

申请日：1996-11-21

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  YAGER, Paul ,  GELB, Michael, H. ,  CARLSON, Paul, A. ,  LUKYANOV, Anatoly, N. ,  GOLDSTEIN, Alex, S. ,  LEE, Kyujin, C.

IPC: A61K47/48

CPC classification number: A61K9/1274 ,  A61K47/6919

Abstract: Therapeutic agents comprising plural therapeutic compounds self-assembled into high axial ration microstructures are described. The therapeutic compounds satisfy the formula HARFM-Th, wherein HARFM is a high axial ratio forming material and Th is a therapeutic associated with the HARFM. The therapeutic agent also can satisfy the formula HARFM-S-Th, wherein S is a spacer. Release of the therapeutic by the agent generally follows either 0-order kinetics or pseudo-first order kinetics. A method for delivering drugs to animals or persons also is described. The method comprises administering an effective amount of a therapeutic self-assembled into an HAR microstructure to the animal or person.

Abstract translation: 本发明涉及包含多种用于形成高轴比微结构的自组装治疗化合物的治疗剂。 所述治疗化合物对应于式HARFM-Th，HARFM是高轴比材料并且Th是与其相关的治疗物质。 治疗剂还可对应于式HARFM-S-Th，其中S是间隔基。 药剂释放的治疗性物质通常遵循一级动力学或伪动力学。 本发明还涉及给动物或人施用有效剂量的自组装治疗物质以形成HAR微结构的方法。

公开(公告)号：WO1997015820A1

公开(公告)日：1997-05-01

申请号：PCT/US1996017352

申请日：1996-10-25

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  YEE, Sinclair, S. ,  JUNG, Chuck, C. ,  SABAN, Stevan, B. ,  DARLING, Robert, B.

IPC: G01N21/55

CPC classification number: G01N21/7703 ,  G01N21/553 ,  G01N27/42

Abstract: This disclosure describes new methods and devices for sensing redox-active analytes in solution. The invention combines a surface plasmon resonance (SPR) sensor and a chemical electrode sensor. A conducting layer which supports SPR is attached to a voltage source. The voltage source is also connected to a reference electrode, which is in the aqueous solution with the SPR sensor. As the voltage is varied, the analytes undergo oxidation and reduction at the surface of the conducting film. The current is measured, just as it would be in a standard chemical electrode, with current peaks appearing at different potentials indicating different ions in the solution. Unlike a standard chemical electrode, the surface of the conducting film is also used to excite a surface plasmon wave (SPW). The SPW provides new information which is not available from any standard chemical electrode, such as the effective index of refraction at the surface of the conducting film as the analytes are being oxidized and/or reduced. This additional source of information can be used to minimize the effects of overlapping stripping peaks and interspecies compound formation as well as determine the thickness of surface layers during measurements. Additionally, the simultaneous determination of reaction properties and optical properties of reaction products can provide additional information about the aqueous support solution such as the quantity and types of natural oxidants in solution, such as oxygen or hydroxides. The formation of oxides and hydroxides will lead to measurably different optical properties.

Abstract translation: 本公开描述了用于在溶液中感测氧化还原活性分析物的新方法和装置。 本发明结合了表面等离子体共振（SPR）传感器和化学电极传感器。 支撑SPR的导电层连接到电压源。 电压源也连接到参考电极，参考电极与SPR传感器在水溶液中。 随着电压的变化，分析物在导电膜的表面经历氧化和还原。 测量电流，就像在标准化学电极中一样，电流峰出现在不同的电位，表示溶液中的不同离子。 与标准化学电极不同，导电膜的表面也用于激发表面等离子体波（SPW）。 SPW提供了不能从任何标准化学电极获得的新信息，例如当分析物被氧化和/或还原时在导电膜的表面处的有效折射率。 这种额外的信息来源可用于最小化重叠剥离峰和种间化合物形成的影响，以及确定测量期间表面层的厚度。 此外，反应产物的反应性质和光学性质的同时测定可以提供关于水性载体溶液的附加信息，例如溶液中的天然氧化剂的量和类型，例如氧气或氢氧化物。 氧化物和氢氧化物的形成将导致可测量的不同的光学性质。

公开(公告)号：WO1997004105A1

公开(公告)日：1997-02-06

申请号：PCT/US1996011688

申请日：1996-07-12

Applicant: UNIVERSITY OF WASHINGTON ,  ROSE, Timothy, M. ,  BOSCH, Marnix, L. ,  STRAND, Kurt ,  TODARO, George, J.

Inventor： UNIVERSITY OF WASHINGTON

IPC: C12N15/54

CPC classification number: C12N9/1252 ,  A61K39/00 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/16022 ,  C12N2710/16422 ,  C12Q1/705

Abstract: This invention provides isolated polynucleotides encoding DNA polymerases of three members of a subfamily of gamma herpes viruses. Two were obtained from macaque monkeys affected with retroperitoneal fibromatosis, the other from human AIDS patients affected with Kaposi's sarcoma. A 454-base pair fragment encoding a region near the active site of the DNA polymerase is 69-83 % identical amongst the three viruses, but only 54-68 % identical with other known gamma herpes sequences and

Abstract translation: 本发明提供编码γ疱疹病毒亚科三个成员的DNA聚合酶的分离的多核苷酸。 2例患者受到腹膜后纤维瘤病影响的猕猴，另一例来自患有卡波西肉瘤的艾滋病患者。 编码DNA聚合酶活性位点附近区域的454碱基对片段在三种病毒中是69-83％相同，但与其他已知的γ疱疹序列只有54-68％相同，与α和β的55％相同 疱疹序列。 还提供了在RFHV / KSHV亚家族中编码来自相关病毒的DNA聚合酶的寡核苷酸。 根据序列数据制备的多核苷酸可用作检测和表征相关序列的试剂。 这些试剂可用于检测RFHV / KSHV亚家族的成员，包括但不限于RFHV，RFHV2和KSHV。 可以通过表达多核苷酸或通过化学合成获得相应的多肽和肽片段。 它们可用于检测潜在存在于受感染受试者血清中的特异性抗体。 它们也可用于设计或筛选通过抑制DNA聚合酶活性来限制病毒复制的药物化合物。

公开(公告)号：WO1997000719A1

公开(公告)日：1997-01-09

申请号：PCT/US1996010737

申请日：1996-06-19

Applicant: UNIVERSITY OF WASHINGTON ,  BENJAMIN, Mark, M. ,  CHANG, Yu-Jung

Inventor： UNIVERSITY OF WASHINGTON

IPC: B01D61/00

CPC classification number: C02F1/441 ,  B01D61/027 ,  B01D61/04 ,  B01D61/145 ,  B01D61/147 ,  B01D61/16 ,  B01D65/08 ,  B01D2311/04 ,  B01D2321/04 ,  B01D2321/162 ,  B01J20/06 ,  C02F1/444 ,  B01D2311/2626 ,  B01D2311/18 ,  B01D2311/103 ,  B01D2311/12

Abstract: Heated iron oxide particles or heated aluminum oxide particles are combined with membrane filtration to remove contaminants from water. The use of the heated particles reduces fouling of the membrane typically encountered when membranes alone are used to remove contaminants from water. The heated particles of iron oxide or aluminum oxide are regenerable and can be reconditioned to revive their adsorption capacity.

Abstract translation: 将加热的氧化铁颗粒或加热的氧化铝颗粒与膜过滤组合以从水中除去污染物。 加热的颗粒的使用减少了当膜单独用于从水中除去污染物时通常遇到的膜的结垢。 氧化铁或氧化铝的加热颗粒是可再生的并且可以重新调节以恢复它们的吸附能力。

公开(公告)号：WO1996041188A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009680

申请日：1996-06-07

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  CHEN, Wei ,  CHEEVER, Martin, A.

IPC: G01N33/569

CPC classification number: G01N33/56977 ,  C07K1/22 ,  C07K4/00

Abstract: The present invention provides peptides that bind to MHC class I molecules. The peptide has a core of 7 to 14 amino acids linked at either its N- or C- terminus to at least two amino acids. The terminal-most additional amino acid contains a reporter group. Thepeptides may be used in a variety of methods, including for tissue typing, vaccine development, or to isolate MHC class I molecules.

Abstract translation: 本发明提供了结合MHC I类分子的肽。 肽具有7至14个氨基酸的核心，其在其N-或C-末端连接至至少两个氨基酸。 末端最多的氨基酸含有报道基团。 这些肽可以以各种方法使用，包括组织分型，疫苗开发或分离MHC I类分子。

公开(公告)号：WO1996020718A3

公开(公告)日：1996-07-11

申请号：PCT/US1995016683

申请日：1995-12-20

Applicant: ZYMOGENETICS, INC. ,  UNIVERSITY OF WASHINGTON

Inventor： ZYMOGENETICS, INC. ,  UNIVERSITY OF WASHINGTON ,  HART, Charles, E. ,  KENAGY, Richard, D. ,  CLOWES, Alexander

IPC: A61K39/395