公开(公告)号：WO1997018840A2

公开(公告)日：1997-05-29

申请号：PCT/US1996018850

申请日：1996-11-21

Applicant: UNIVERSITY OF WASHINGTON

Inventor： UNIVERSITY OF WASHINGTON ,  YAGER, Paul ,  GELB, Michael, H. ,  CARLSON, Paul, A. ,  LUKYANOV, Anatoly, N. ,  GOLDSTEIN, Alex, S. ,  LEE, Kyujin, C.

IPC: A61K47/48

CPC classification number: A61K9/1274 ,  A61K47/6919

Abstract: Therapeutic agents comprising plural therapeutic compounds self-assembled into high axial ration microstructures are described. The therapeutic compounds satisfy the formula HARFM-Th, wherein HARFM is a high axial ratio forming material and Th is a therapeutic associated with the HARFM. The therapeutic agent also can satisfy the formula HARFM-S-Th, wherein S is a spacer. Release of the therapeutic by the agent generally follows either 0-order kinetics or pseudo-first order kinetics. A method for delivering drugs to animals or persons also is described. The method comprises administering an effective amount of a therapeutic self-assembled into an HAR microstructure to the animal or person.

Abstract translation: 本发明涉及包含多种用于形成高轴比微结构的自组装治疗化合物的治疗剂。 所述治疗化合物对应于式HARFM-Th，HARFM是高轴比材料并且Th是与其相关的治疗物质。 治疗剂还可对应于式HARFM-S-Th，其中S是间隔基。 药剂释放的治疗性物质通常遵循一级动力学或伪动力学。 本发明还涉及给动物或人施用有效剂量的自组装治疗物质以形成HAR微结构的方法。