公开(公告)号：AU2009231993B2

公开(公告)日：2013-10-10

申请号：AU2009231993

申请日：2009-03-25

Applicant: VERTEX PHARMA

Inventor： GROOTENHUIS PETER ,  ZHOU JINGLAN ,  HADIDA-RUAH SARA ,  BEAR BRIAN ,  MILLER MARK

IPC: C07D213/75 ,  A61K31/44 ,  A61K31/4427 ,  A61P43/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to modulators of ATP-B inding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, of formula (I), and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2012201325A1

公开(公告)日：2012-03-29

申请号：AU2012201325

申请日：2012-03-05

Applicant: VERTEX PHARMA

Inventor： RUAH SARA HADIDA ,  HAMILTON MATTHEW ,  MILLER MARK ,  GROOTENHUIS PETER D J ,  BEAR BRIAN ,  MCCARTHY JASON ,  ZHOU JINGLAN

IPC: C07D405/12 ,  A61K31/4418 ,  A61K31/5585 ,  A61P11/00 ,  C07D213/75 ,  C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：MX2011004834A

公开(公告)日：2011-07-28

申请号：MX2011004834

申请日：2009-11-06

Applicant: VERTEX PHARMA

Inventor： MILLER MARK T ,  RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  ZHOU JINGLAN ,  MCCARTNEY JASON ,  GOOR FREDRICK VAN ,  NUMA MEHDI MICHEL DJAMEL ,  BEAR BRIAN

IPC: C07D405/12 ,  A61K31/404 ,  A61P3/00 ,  A61P25/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/18

Abstract: Los compuestos de la presente invención y composiciones farmacéuticamente aceptables de los mismos, son útiles como moduladores de los transportadores de Casetes Enlazadores de ATP ("ABC") o sus fragmentos, incluyendo el Regulador de Conductancia Transmembranal de la Fibrosis Cística (CFTR"). La presente invención igualmente se refiere a métodos para tratar enfermedades mediadas por el transportador de ABC, utilizando los compuestos de la presente invención.

公开(公告)号：CA2742980A1

公开(公告)日：2010-05-14

申请号：CA2742980

申请日：2009-11-06

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  MILLER MARK T ,  MCCARTNEY JASON ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL ,  ZHOU JINGLAN ,  BEAR BRIAN

IPC: C07D405/02 ,  A61K31/404 ,  A61P3/00 ,  A61P25/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/18

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：AU2009231993A1

公开(公告)日：2009-10-08

申请号：AU2009231993

申请日：2009-03-25

Applicant: VERTEX PHARMA

Inventor： BEAR BRIAN ,  MILLER MARK ,  HADIDA-RUAH SARA ,  GROOTENHUIS PETER ,  ZHOU JINGLAN

IPC: C07D213/75 ,  A61K31/44 ,  A61K31/4427 ,  A61P43/00 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14

公开(公告)号：CA2716109A1

公开(公告)日：2009-09-03

申请号：CA2716109

申请日：2009-02-25

Applicant: VERTEX PHARMA

Inventor： HADIDA-RUAH SARA ,  MILLER MARK ,  ZHOU JINGLAN ,  BEAR BRIAN

IPC: C07D213/75 ,  A61K31/435 ,  A61K31/4965 ,  A61K31/505 ,  A61P3/00 ,  A61P25/00 ,  C07D239/42 ,  C07D241/20

Abstract: The present invention relates to modulators of ATP-B inding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2009219363A1

公开(公告)日：2009-09-03

申请号：AU2009219363

申请日：2009-02-25

Applicant: VERTEX PHARMA

Inventor： ZHOU JINGLAN ,  HADIDA-RUAH SARA ,  MILLER MARK ,  BEAR BRIAN

IPC: C07D213/75 ,  A61K31/435 ,  A61K31/4965 ,  A61K31/505 ,  A61P3/00 ,  A61P25/00 ,  C07D239/42 ,  C07D241/20

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：HK1125366A1

公开(公告)日：2009-08-07

申请号：HK09103553

申请日：2009-04-17

Applicant: VERTEX PHARMA

Inventor： RUAH SARA HADIDA ,  HAMILTON MATTHEW ,  MILLER MARK ,  GROOTENHUIS PETER D J ,  BEAR BRIAN ,  MCCARTHY JASON ,  ZHOU JINGLAN

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention..

公开(公告)号：NO20091720L

公开(公告)日：2009-07-21

申请号：NO20091720

申请日：2009-04-30

Applicant: VERTEX PHARMA

Inventor： BEAR BRIAN ,  RUAH SARA HADIDA ,  ZHOU JINGLAN ,  MILLER MARK

IPC: C07D471/04

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof of formula (I), including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：CA2705562A1

公开(公告)日：2009-05-22

申请号：CA2705562

申请日：2008-11-14

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARA ,  MILLER MARK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  GROOTENHUIS PETER D J

IPC: C07D217/22 ,  A61K31/472 ,  A61K31/4725 ,  A61P11/00 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14

Abstract: Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.