公开(公告)号：MX2012003343A

公开(公告)日：2012-08-17

申请号：MX2012003343

申请日：2010-09-17

Applicant: VERTEX PHARMA

Inventor： FANNING LEV T D ,  AMBHAIKAR NARENDRA BHALCHANDRA ,  BEAR BRIAN RICHARD ,  HUGHES ROBERT ,  LITTLER BENJAMIN

IPC: C07D487/08

Abstract: La presente invención se relaciona con un proceso para preparar compuestos azabicíclicos que son intermediarios útiles para sintetizar compuestos farmacéuticos o las sales de los mismos.

公开(公告)号：AU2010310612A2

公开(公告)日：2012-08-16

申请号：AU2010310612

申请日：2010-10-21

Applicant: VERTEX PHARMA

Inventor： AMBHAIKAR NARENDRA BHALCHANDRA ,  HUGHES ROBERT ,  HURLEY DENNIS JAMES ,  LEE ELAINE CHUNGMIN ,  LITTLER BENJAMIN ,  NUMA MEHDI ,  ROEPER STEFANIE ,  SHETH URVI

IPC: C07D215/56 ,  C07D487/08

Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2. 1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A- HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：CA2778492A1

公开(公告)日：2011-04-28

申请号：CA2778492

申请日：2010-10-21

Applicant: VERTEX PHARMA

Inventor： AMBHAIKAR NARENDRA BHALCHANDRA ,  HUGHES ROBERT ,  HURLEY DENNIS JAMES ,  LEE ELAINE CHUNGMIN ,  LITTLER BENJAMIN ,  NUMA MEHDI ,  ROEPER STEFANIE ,  SHETH URVI

IPC: C07D215/56 ,  C07D487/08

Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2. 1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A- HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.

公开(公告)号：BRPI0608602A2

公开(公告)日：2010-01-19

申请号：BRPI0608602

申请日：2006-05-09

Applicant: VERTEX PHARMA

Inventor： ANSELL GRAHAM ,  BLYTHE TODD A ,  JONES ANDREW D ,  LITTLER BENJAMIN ,  LOOKER ADAM ,  NYCE PHILIP L ,  SNOONIAN JOHN R

IPC: C07C275/42 ,  C07C271/34 ,  C07D307/16 ,  C07D413/12

Abstract: The present invention relates to processes for preparing biaryl ureas derivatives and analogs thereof. The invention also provides compounds useful as intermediates in the processes of the present invention. The process is useful for preparing compounds that inhibit IMPDH.

公开(公告)号：CA2975048C

公开(公告)日：2024-01-02

申请号：CA2975048

申请日：2016-01-29

Applicant: BIOMED VALLEY DISCOVERIES INC ,  VERTEX PHARMA

Inventor： DECRESCENZO GARY ,  WELSCH DEAN ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  KESHAVARZ-SHOKRI ALI ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA ,  ALARGOVA ROSSITZA GUEORGUIEVA

IPC: C07D401/04 ,  A61K31/4439 ,  A61P35/00

Abstract: The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer. It has been discovered that crystalline forms of 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1 H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyl]amide can be prepared which exhibit improved properties, e.g. surprisingly improved stability and improved solubility characteristics. Thus, the present invention provides crystalline 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyljamide.

公开(公告)号：AU2023254937A1

公开(公告)日：2023-11-16

申请号：AU2023254937

申请日：2023-10-25

Applicant: BIOMED VALLEY DISCOVERIES INC ,  VERTEX PHARMA

Inventor： DECRESCENZO GARY ,  WELSCH DEAN ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  KESHAVARZ-SHOKRI ALI ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA

IPC: C07D401/04

Abstract: : The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：AU2020257041C1

公开(公告)日：2022-10-27

申请号：AU2020257041

申请日：2020-10-20

Applicant: BIOMED VALLEY DISCOVERIES INC ,  VERTEX PHARMA

Inventor： DECRESCENZO GARY ,  WELSCH DEAN ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  KESHAVARZ-SHOKRI ALI ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA ,  ALARGOVA ROSSITZA GUEORGUIEVA

IPC: C07D401/04

Abstract: : The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：AU2022228084A1

公开(公告)日：2022-09-29

申请号：AU2022228084

申请日：2022-09-05

Applicant: BIOMED VALLEY DISCOVERIES INC ,  VERTEX PHARMA

Inventor： WELSCH DEAN ,  DECRESCENZO GARY ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  KESHAVARZ-SHOKRI ALI ,  ALARGOVA ROSSITZA GUEORGUIEVA ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA

IPC: C07D401/04

Abstract: : The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：SG10202101979TA

公开(公告)日：2021-04-29

申请号：SG10202101979T

申请日：2016-01-29

Applicant: BIOMED VALLEY DISCOVERIES INC ,  VERTEX PHARMA

Inventor： DECRESCENZO GARY ,  WELSCH DEAN ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  KESHAVARZ-SHOKRI ALI ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA ,  ALARGOVA ROSSITZA GUEORGUIEVA

Abstract: The present invention provides crystalline forms of a compound of formula (I):Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：AU2016211246B2

公开(公告)日：2020-08-27

申请号：AU2016211246

申请日：2016-01-29

Applicant: BIOMED VALLEY DISCOVERIES INC ,  VERTEX PHARMA

Inventor： DECRESCENZO GARY ,  WELSCH DEAN ,  VLAHOVA PETINKA I ,  BOERRIGTER STEPHAN X M ,  ARONOV ALEXANDER ,  KESHAVARZ-SHOKRI ALI ,  SCANGAS ALEXANDER N ,  STAVROPOULOS KATHY ,  LITTLER BENJAMIN ,  KADIYALA IRINA NIKOLAEVNA ,  ALARGOVA ROSSITZA GUEORGUIEVA

IPC: C07D401/04

Abstract: The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer. It has been discovered that crystalline forms of 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1 H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyl]amide can be prepared which exhibit improved properties, e.g. surprisingly improved stability and improved solubility characteristics. Thus, the present invention provides crystalline 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyljamide.