公开(公告)号：WO2008002045A1

公开(公告)日：2008-01-03

申请号：PCT/KR2007/003068

申请日：2007-06-25

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  YOO, Suk-Jae ,  LEE, Bong-Ju

Inventor： YOO, Suk-Jae ,  LEE, Bong-Ju

IPC: H01L21/3065

CPC classification number: H01L21/3065 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/2037 ,  H01J37/3174

Abstract: There is provided a method for forming a pattern on a wafer by direct etching with neutral particle beam, comprising a) penetrating the neutral particle beam through a mask into which the pattern is formed, b) directly colliding the neutral particle beam passed through the mask with the wafer onto which no photo-resist is coated, and c) removing wafer-forming material of a region that comes in contact with the neutral particle beam to form negative pattern on the wafer. The method makes it possible to form the pattern on the wafer by direct etching, even without coating of the photo-resist, exposure, developing or removal of the photo-resist. And it avoids disadvantages caused by direct contact of shields with the wafer, such as difficulty in the organized arrangement of the shields onto the wafer and damage to the wafer by the shields.

Abstract translation: 提供了一种通过用中性粒子束直接蚀刻在晶片上形成图案的方法，包括：a）穿过中性粒子束穿过形成图案的掩模，b）直接碰撞通过掩模的中性粒子束 其上没有涂覆光致抗蚀剂的晶片，以及c）去除与中性粒子束接触的区域的晶片形成材料，以在晶片上形成负图案。 该方法使得可以通过直接蚀刻在晶片上形成图案，即使不涂布光致抗蚀剂，曝光，显影或去除光刻胶。 并且避免了屏蔽与晶片的直接接触所引起的缺点，例如屏蔽件有组织地布置在晶片上并且被屏蔽件损坏晶片的困难。

公开(公告)号：WO2007049880A1

公开(公告)日：2007-05-03

申请号：PCT/KR2006/004278

申请日：2006-10-20

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  KIM, Hae Jin ,  LEE, Jin Bae

Inventor： KIM, Hae Jin ,  LEE, Jin Bae

IPC: B82B3/00 ,  B82B1/00

CPC classification number: C01G45/02 ,  B82Y30/00 ,  C01P2002/72 ,  C01P2004/02 ,  C01P2004/04 ,  C01P2004/13 ,  C01P2004/16 ,  C01P2004/60 ,  C01P2006/40 ,  C01P2006/60 ,  C04B35/053 ,  C04B35/111 ,  C04B38/00 ,  C04B2111/00008 ,  C30B7/00 ,  C30B29/16 ,  C30B29/602 ,  H01M4/0404 ,  H01M4/043 ,  H01M4/505 ,  H01M4/621 ,  H01M4/625 ,  H01M10/052 ,  Y02E60/122 ,  Y02P70/54 ,  C04B38/0054

Abstract: The present invention relates to methods for manufacturing manganese oxide nanotubes/nanorods using an anodic aluminum oxide (AAO) template. In the inventive methods, the manganese oxide nanotubes/nanorods are manufactured in mild conditions using only a manganese oxide precursor and an anodic aluminum oxide template without using any solvent. The nanotubes/nanorods having uniform size can be easily obtained by adsorbing the manganese oxide precursor onto the surface of the anodic aluminum oxide template by a vacuum forming process using a vacuum filtration apparatus so as to maintain the shape of nanotubes/nanorods and drying the manganese oxide nanotubes. The manganese oxide nanotubes/nanorods made according to the inventive methods can be used as economic hydrogen reservoirs, the electrode of lithium secondary batteries, or the energy reservoirs of vehicles or other transport means.

Abstract translation: 本发明涉及使用阳极氧化铝（AAO）模板制造氧化锰纳米管/纳米棒的方法。 在本发明的方法中，仅使用锰氧化物前体和阳极氧化铝模板，而不使用任何溶剂，在温和条件下制造氧化锰纳米管/纳米棒。 通过使用真空过滤装置的真空成型方法将锰氧化物前体吸附到阳极氧化铝模板的表面上，以保持纳米管/纳米棒的形状并干燥锰，可以容易地获得具有均匀尺寸的纳米管/纳米棒 氧化物纳米管。 根据本发明方法制备的氧化锰纳米管/纳米棒可以用作经济氢气储存器，锂二次电池的电极，或车辆的能量储存器或其他运输工具。

公开(公告)号：WO2006123883A1

公开(公告)日：2006-11-23

申请号：PCT/KR2006/001825

申请日：2006-05-16

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  SEM TECHNOLOGY CO., LTD ,  LEE, Bong-Ju ,  JUNG, Yong-Ho

Inventor： LEE, Bong-Ju ,  JUNG, Yong-Ho

IPC: C01B3/02

CPC classification number: C01B3/342 ,  B01J19/088 ,  B01J2219/0869 ,  B01J2219/0875 ,  C01B3/045 ,  C01B3/22 ,  C01B3/24 ,  C01B2203/0266 ,  C01B2203/043 ,  C01B2203/0861 ,  Y02E60/364

Abstract: The present invention relates to an apparatus and a method for producing hydrogen gas. The hydrogen gas production apparatus of the present invention comprises a) a dielectric hollow tube, b) a means for maintaining the dielectric hollow tube to a reduced pressure, c) a microwave source that generates a microwave, d) a waveguide coupled to the microwave source that applies the microwave to the dielectric hollow tube, e) a gas supply source that supplies a hydrogen element-containing gas into the dielectric hollow tube, wherein the hydrogen element-containing gas supplied into the dielectric hollow tube undergoes plasma discharge with aid of the microwave from the waveguide and produces reaction products including hydrogen gas through intramolecular bond breakage rather than heat decomposition, by collision of an electron produced by the plasma discharge with the hydrogen element-containing gas, and f) a separator that separates the hydrogen gas from the reaction products. The hydrogen gas production apparatus has a simple constitution and provides small scaled production of the hydrogen gas in a simple and efficient manner.

Abstract translation: 本发明涉及一种用于生产氢气的装置和方法。 本发明的氢气制造装置包括a）电介质中空管，b）用于将电介质中空管保持在减压状态的装置，c）产生微波的微波源，d）与微波耦合的波导 将微波施加到电介质中空管的源; e）将含氢元素的气体供应到电介质中空管中的气体供应源，其中供应到电介质中空管中的含氢元素的气体经历等离子体放电，借助于 来自波导的微波，通过分子内键断裂而不是热分解产生包括氢气的反应产物，通过等离子体放电产生的电子与含氢元素的气体的碰撞，以及f）将氢气与 反应产物。 氢气制造装置具有简单的结构，并且以简单且有效的方式提供小规模生产氢气。

公开(公告)号：WO2006028310A1

公开(公告)日：2006-03-16

申请号：PCT/KR2004/002577

申请日：2004-10-08

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  AHN, Yeong Hee ,  YOO, Jong Shin ,  LEE, Jae Yong ,  KIM, Jin Young ,  CHO, Kun

Inventor： AHN, Yeong Hee ,  YOO, Jong Shin ,  LEE, Jae Yong ,  KIM, Jin Young ,  CHO, Kun

IPC: C12Q1/37

CPC classification number: G01N33/6842 ,  G01N33/6848

Abstract: The present invention relates to a method for phosphorylation site-specific labeling of phosphoproteome with a site-specific tagging reagent and analyzing of the resulting labeled one, more especially, a method for in-situ tagging of phosphorylation sites of phosphoproteins retained in polymeric gel with a nucleophilic tagging reagent. It also relates a method for generating new proteolytic cleavable sites at formerly phosphorylation sites by a proper choice of a nucleophilic tagging reagent. It also relates to a method for phosphopeptides analysis and phosphorylation site identification by in-gel digestion of the previously in-gel tagged proteins and subsequent mass analysis of the resulting peptides. The invention provides in-gel chemical tagging method for phosphoaminoacid residue of phosphoproteins retained in polymeric gel matrix. Phosphoprotein can be immobilized into gel matrix by a variety of methods such as gel electrophoresis. The immobilized phosphoproteins are retained in gel matrix during tagging reaction to phosphorylated aminoacid residue of phosphoproteins, and the resulting tagged proteins are also retained in gel matrix till following purification steps like washing of the tagging reagents are accomplished. The tagged proteins is digested by protease, and the resulting digested peptides is released from gel into solution and applied for peptide mass analysis.

Abstract translation: 本发明涉及用位点特异性标记试剂对磷酸化蛋白质进行磷酸化位点特异性标记的方法，并分析得到的标记物，更具体地说，一种用于原位标记保留在聚合物凝胶中的磷酸化蛋白的磷酸化位点的方法， 亲核标记试剂。 它还涉及通过适当选择亲核标记试剂在以前的磷酸化位点产生新的蛋白水解可切割位点的方法。 它还涉及通过凝胶内消化先前凝胶内标记蛋白的磷酸肽分析和磷酸化位点鉴定的方法以及随后对所得肽的质量分析。 本发明提供了凝胶化学标记方法，用于保留在聚合物凝胶基质中的磷酸蛋白的磷酸氨基酸残基。 磷酸蛋白可以通过各种方法如凝胶电泳固定在凝胶基质中。 在磷酸化蛋白质的磷酸化氨基酸残基的标签反应期间，将固定的磷酸蛋白质保留在凝胶基质中，并且所得到的标记蛋白质也保留在凝胶基质中，直到完成标记试剂的洗涤之后的纯化步骤。 标记的蛋白质被蛋白酶消化，并将得到的消化肽从凝胶释放到溶液中并用于肽质量分析。

公开(公告)号：WO2005016948A1

公开(公告)日：2005-02-24

申请号：PCT/KR2003/001654

申请日：2003-08-14

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  AHN, Yeong Hee ,  YOO, Jong Shin ,  KIM, Soohyun

Inventor： AHN, Yeong Hee ,  YOO, Jong Shin ,  KIM, Soohyun

IPC: C07H1/00

CPC classification number: C07H1/00

Abstract: The present invention relates to the method for tagging of carbohydrates with active methylene compound. Particularly, it relates to the method for tagging of carbohydrates with active methylene compound comprising the step of preparing carbohydrate conjugate in which carbohydrate and methylene compound are combined by mixing carbohydrate mixture and methylene compound under aqueous polar aprotic solvent containing amine base catalyst. The tagging method of the present invention does not need many kinds of chemical reagent and the reactions can be taken even in the presence of certain amount of impurities. So, it can be used for the analysis of oligosaccharide present in the various kinds of samples.

Abstract translation: 本发明涉及用活性亚甲基化合物标记碳水化合物的方法。 特别涉及用活性亚甲基化合物标记碳水化合物的方法，包括制备碳水化合物缀合物的步骤，其中碳水化合物和亚甲基化合物通过混合碳水化合物混合物和亚甲基化合物在含有胺基催化剂的极性非质子溶剂的水溶液下混合。 本发明的标记方法不需要多种化学试剂，即使在存在一定量的杂质的情况下也可以进行反应。 因此，可用于各种样品中存在的寡糖的分析。

公开(公告)号：WO2012074234A2

公开(公告)日：2012-06-07

申请号：PCT/KR2011/008866

申请日：2011-11-21

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  CHOI, Myoung Choul ,  PARK, A Leum ,  KIM, Hyun Sik ,  KIM, Seung Yong ,  YOO, Jong Shin

Inventor： CHOI, Myoung Choul ,  PARK, A Leum ,  KIM, Hyun Sik ,  KIM, Seung Yong ,  YOO, Jong Shin

IPC: G01N27/62 ,  H01J49/26

CPC classification number: H01J49/02 ,  H01J49/0027 ,  H01J49/065 ,  H01J49/38

Abstract: A Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) includes: an ionization source generating ions; a deceleration lens, on which the ions generated by the ionization source and spatially dispersed are incident, selectively decelerating the incident ions so as to decrease the distance between the ions; and an ion cyclotron resonance cell on which the ions passing through the deceleration lens are incident. By preventing dispersing of ions due to mass difference and converging the ions using the deceleration lens, the mass range that can be measured at one time can be extended. Also, measurement sensitivity can be improved since the ions are effectively introduced to the ICR cell.

Abstract translation: 傅里叶变换离子回旋共振质谱仪（FT-ICR MS）包括：产生离子的电离源; 由离子源产生的并且空间分散的离子入射的减速透镜选择性地使入射离子减速以减小离子之间的距离; 以及通过减速透镜的离子入射到其上的离子回旋共振单元。 通过防止由于质量差导致的离子分散和使用减速透镜会聚离子，可以延长一次可以测量的质量范围。 此外，由于离子被有效地引入ICR单元，所以可以提高测量灵敏度。

公开(公告)号：WO2009145377A1

公开(公告)日：2009-12-03

申请号：PCT/KR2008/003061

申请日：2008-05-30

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  LEE, Sun-Gyu ,  JEUNG, Jong-Man ,  KIM, Youn-Joong

Inventor： LEE, Sun-Gyu ,  JEUNG, Jong-Man ,  KIM, Youn-Joong

IPC: G01N1/28

CPC classification number: G01N1/42

Abstract: A workstation for cryogenic transmission electron microscopy. Liquid nitrogen, which is confined in a space defined by the step of a transparent cover detachably mounted on an insulated vessel, serves as a boundary layer for preventing moisture in the atmosphere from being frozen on the top of the transparent cover. Further, a height adjuster is disposed on the lower surface of a stand on which a Dewar vessel is disposed, and inclines the stand such that an installation height of the Dewar vessel is higher than that of the insulated vessel. Thereby, the liquid nitrogen cannot come into direct contact with an O- ring interposed between a holder and a holder insertion socket, and blocks of ice generated by mixture of moisture with the liquid nitrogen can be collected to one side to thus prevent contamination of the sample.

Abstract translation: 用于低温透射电子显微镜的工作站。 被限制在由可拆卸地安装在隔热容器上的透明盖的步骤限定的空间中的液氮用作防止大气中的水分冻结在透明盖的顶部上的边界层。 此外，高度调节器设置在设置有杜瓦瓶的支架的下表面上，并且倾斜支架，使得杜瓦瓶的安装高度高于隔热容器的安装高度。 因此，液氮不能与插入在保持器和保持器插入座之间的O形环直接接触，并且通过将水分与液氮混合产生的冰块可以收集到一侧，从而防止污染 样品。

公开(公告)号：WO2009116696A1

公开(公告)日：2009-09-24

申请号：PCT/KR2008/001628

申请日：2008-03-21

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  JEUNG, Jong-Man ,  KIM, Youn-Joong

Inventor： JEUNG, Jong-Man ,  KIM, Youn-Joong

IPC: G01N1/28 ,  H01L21/66

CPC classification number: G01N1/42 ,  G01K1/14 ,  G01K2203/00 ,  H01J37/20 ,  H01J37/26 ,  H01J2237/2001 ,  H01J2237/2065

Abstract: The present invention relates to an apparatus for measuring the temperature of a cryo EM- holder specimen cradle used in a transmission electron microscope (TEM) and a method for measuring the temperature thereof using the same. The apparatus for measuring the temperature of a cryo EM-holder specimen cradle can measure an exact temperature by directly measuring the temperature of the cryo EM-holder specimen cradle used in a transmission electron microscope (TEM), as well as perform an experiment on the cryo EM-holder in the vacuum state as the inside of the TEM, and a method for measuring the temperature thereof using the same.

Abstract translation: 本发明涉及一种用于测量透射电子显微镜（TEM）中使用的低温EM支架样本支架的温度的装置和使用其的测量其温度的方法。 用于测量冷冻EM支架样品支架的温度的装置可以通过直接测量透射电子显微镜（TEM）中使用的低温EM支架样品支架的温度来测量精确温度，以及对 作为TEM的内部的真空状态的低温EM-保持器以及使用其的温度的测定方法。

公开(公告)号：WO2009035208A1

公开(公告)日：2009-03-19

申请号：PCT/KR2008/003591

申请日：2008-06-24

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  MOON, Won Jin ,  PARK, Byung Kyu ,  KIM, Youn Joong ,  LEE, Jee Young ,  LEE, Sang Hee ,  BAE, Dong Sik

Inventor： MOON, Won Jin ,  PARK, Byung Kyu ,  KIM, Youn Joong ,  LEE, Jee Young ,  LEE, Sang Hee ,  BAE, Dong Sik

IPC: G01N1/28 ,  G01N23/22

CPC classification number: H01J37/20 ,  G01N23/046 ,  G01N2223/419 ,  H01J37/26 ,  H01J2237/20292 ,  H01J2237/204 ,  H01J2237/226 ,  H01J2237/2611 ,  H01J2237/2617

Abstract: Disclosed is a moon grid for transmission electron microscopy tomography, including a mesh sheet for protecting an upper objects and a support film formed on the mesh sheet and having nanoparticles dispersed throughout, in which the nanoparticles dispersed throughout the support film are used as reference points in the reconstruction of two-dimensional transmission electron microscopy images into a three-dimensional image, thus omitting a process of attaching markers in the course of preparation of a sample and easily forming reference points even on a sample to which it is impossible to attach markers. A method of fabricating such a moon grid is also provided.

Abstract translation: 公开了一种用于透射电子显微镜断层摄影的月球网格，包括用于保护上部物体的网片和形成在网片上的支撑膜，并且具有分散在其中的纳米颗粒，其中分散在整个支撑膜上的纳米颗粒用作参考点 将二维透射电子显微镜图像重建成三维图像，因此省略了在样品制备过程中附着标记的过程，并且即使在不可能附着标记的样品上也容易形成参考点。 还提供了一种制造这种月球栅格的方法。

公开(公告)号：WO2008140150A1

公开(公告)日：2008-11-20

申请号：PCT/KR2007/003576

申请日：2007-07-25

Applicant: FOOD SCIENCE CO., LTD. ,  KOREA BASIC SCIENCE INSTITUTE ,  KIM, Hwa-Jin ,  RYU, Do-Hyun ,  HWANG, Geum-Sook ,  KIM, Kun-Hong ,  PARK, Jin-Hyun ,  KIM, Kyung-Hwa ,  SIM, Jae-Yi ,  LEE, Mi-Young

Inventor： KIM, Hwa-Jin ,  RYU, Do-Hyun ,  HWANG, Geum-Sook ,  KIM, Kun-Hong ,  PARK, Jin-Hyun ,  KIM, Kyung-Hwa ,  SIM, Jae-Yi ,  LEE, Mi-Young

IPC: C07D307/93 ,  C07D307/77 ,  C07D493/10

CPC classification number: C07D307/93 ,  C07D493/10 ,  C07D519/00

Abstract: The present invention relates to novel octahydro indeno derivatives, pharmaceutically acceptable salts, hydrates, solvates and stereoisomers thereof, and pharmaceutical compositions for treating or preventing cancer comprising the same. Since the compounds according to the present invention have high cytotoxicity against cancer cells, they may be usefully used as medical uses such as anticancer agents or antibiotics.

Abstract translation: 本发明涉及新颖的八氢茚并衍生物，其药学上可接受的盐，水合物，溶剂化物和立体异构体，以及用于治疗或预防包含其的癌症的药物组合物。 由于根据本发明的化合物对癌细胞具有高的细胞毒性，所以它们可以有用地用作抗癌剂或抗生素等医疗用途。